期刊首页 优先出版 当期阅读 过刊浏览 作者中心 关于期刊 English

2020年 第14卷 第1期

摘要

关键词

相关研究

回顶部

《医学前沿（英文）》 >> 2020年 第14卷 第1期 doi: 10.1007/s11684-019-0733-5

The epidemiology of norovirus gastroenteritis in China: disease burden and distribution of genotypes

. Key Laboratory of Medical Molecular Virology of MoE & MoH, and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.. Laboratory of Molecular Biology, Training Center of Medical Experiments, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.. Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.. Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford OX1 2JD, UK.. Children’s Hospital, Fudan University, Shanghai 200032, China

录用日期： 2019-12-11 发布日期： 2019-12-11
HTML26 PDF 5 收藏 0

下一篇 上一篇

摘要

With the improvements of sanitation and nationwide safe water supply the occurrence of bacterial diarrhea declined remarkably, while viruses became the leading causes of acute gastroenteritis (AGE). Of these viruses, noroviruses (NoVs) are responsible for a considerable burden of gastroenteritis, especially in children<2 years and elderly≥65 years. NoVs circulating in the Chinese population are antigenically highly diverse with the genotype GII.4 being the dominant strain followed by GII.3. Given the widespread contamination in environmental sources, and highly infectious nature of NoVs, vaccination would be the desirable strategy for the control of NoV infections. However, a better understanding of acquired immunity after infection, and a reliable immunological surrogate marker are urgently needed, since two vaccine candidates based on virus-like particles (VLPs) are currently moving into clinical evaluations in China.

相关研究