《化学科学与工程前沿（英文）》
>> 2019年
第13卷
第2期
doi:
10.1007/s11705-019-1803-6
RESEARCH ARTICLE
Multifunctional antimicrobial chlorhexidine polymers by remote plasma assisted vacuum deposition
. Consejo Superior de Investigaciones Científicas. Instituto de Ciencia de Materiales de Sevilla (CSIC-Universidad de Sevilla) c/Américo Vespucio 49, 41092 Sevilla, Spain.. Facultad de Odontología, Universidad de Sevilla (USE) c/Avicena, 41009 Sevilla, Spain
录用日期：
2019-04-09
发布日期：
2019-04-09
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摘要
Novel antibacterial materials for implants and medical instruments are essential to develop practical strategies to stop the spread of healthcare associated infections. This study presents the synthesis of multifunctional antibacterial nanocoatings on polydimethylsiloxane (PDMS) by remote plasma assisted deposition of sublimated chlorhexidine powders at low pressure and room temperature. The obtained materials present effective antibacterial activity against K12, either by contact killing and antibacterial adhesion or by biocide agents release depending on the synthetic parameters. In addition, these multifunctional coatings allow the endure hydrophilization of the hydrophobic PDMS surface, thereby improving their biocompatibility. Importantly, cell-viability tests conducted on these materials also prove their non-cytotoxicity, opening a way for the integration of this type of functional plasma films in biomedical devices.
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