Cities are incorporating smart and green infrastructure components in their urban design policies, adapting existing and new infrastructure systems to integrate technological advances to mitigate extreme weather due to climate change. Research has illustrated that smart green infrastructure (SGI) provides not only climate change resilience but also many health and wellbeing benefits that improve the quality of life of citizens. With the growing demand for smart technology, a series of problems and challenges, including governance, privacy, and security, must be addressed. This paper explores the potential to transition from grey, green, or smart silos to work with nature-based solutions and smart technology to help change cities to achieve considerable environmental and socio-economic benefits. The concepts of grey, green, and smart infrastructure are presented, and the needs, benefits, and applications are investigated. Moreover, the advantages of using integrated smart, green nature-based solutions are discussed. A comprehensive literature review is undertaken with keyword searches, including journal papers, stakeholder and case study reports, and local authority action plans. The methodology adopts multimethod qualitative information review, including literature, case studies, expert interviews, and documentary analysis. Published data and information are analysed to capture the key concepts in implementing SGI systems, such as storm-water control, flood and coastal defense, urban waste management, transportation, recreation, and asset management. The paper investigates the elimination of silo approaches and the alleviation of the destructions caused by extreme weather events using these interdependent SGI systems supported by novel data-driven platforms to provide nature-based solutions to boost the health and wellbeing of the residents.