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《工程(英文)》 >> 2017年 第3卷 第1期 doi: 10.1016/J.ENG.2017.01.006

益生菌辅助治疗类风湿关节炎的益处:随机对照临床试验荟萃分析和系统综述

a State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China
b Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau, China

录用日期: 2017-02-10 发布日期: 2017-02-28

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摘要

肠道和口腔菌群是影响类风湿关节炎(rheumatoid arthritis, 简称类风关) 发生、发展的重要因素。近年来的研究表明益生菌可改善实验性大鼠关节炎,但益生菌辅助治疗类风关的临床疗效尚未定论。本研究旨在对益生菌辅助治疗类风关的研究报告进行荟萃分析,为益生菌辅助治疗类风关提供临床证据。我们将符合随机对照临床试验标准的文献报告纳入荟萃分析内容,分益生菌辅助治疗组(治疗组) 和非益生菌辅助治疗组(对照组) 进行比较,两者均使用缓解风湿病情药物(DMARDs)。采用Review Manager 5.3.3 对6 个随机对照临床试验报告共246 例患者进行荟萃分析,结果表明,治疗组与对照组在关节炎病情缓解指数ACR20 和DAS28 评分方面的差异无显著意义,但益生菌辅助治疗能显著降低C 反应蛋白、致炎性细胞因子肿瘤坏死因子–α 和白介素–1β 的表达,同时使IL-10的表达上升。通过对益生菌治疗类风关的综合作用进行系统评估,我们发现益生菌辅助治疗类风关是有益的。但是,目前缺乏高质量的临床试验报告,需要开展更多的多中心、大样本、双盲、随机对照临床试验。

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