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《工程(英文)》 >> 2017年 第3卷 第3期 doi: 10.1016/J.ENG.2017.03.023

药物连续结晶进展

a School of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300072, China
b Collaborative Innovation Center of Chemical Science and Chemical Engineering, Tianjin University, Tianjin 300072, China

收稿日期: 2017-03-25 修回日期: 2017-05-10 录用日期: 2017-05-11 发布日期: 2017-06-19

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摘要

结晶是药物工业中重要的单元操作。现阶段大部分的药物结晶过程都是间歇的,但是由于间歇产品的批间差异以及低的生产效率,连续结晶越来越受到人们的重视。在过去的几年中,连续结晶已经取得了一些进展以使其能够满足不同的需求。本文将从产品工程的角度总结药物连续结晶的进展。不同形式结晶器的主要区别在于其停留时间分布的不同。文中比较了不同连续结晶形式的优点和缺点,总结了使用连续结晶满足不同质量需求的方法。发现连续结晶在粒度和形状控制上有优势,但是在过程收率上低于间歇结晶过程,特别是在生产手性晶体时。最后对不同的控制方案进行了比较。

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