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《工程(英文)》 >> 2018年 第4卷 第2期 doi: 10.1016/j.eng.2018.03.007

组织工程模板中的生物相容性途径

Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC 27101, USA

收稿日期: 2017-03-13 修回日期: 2017-10-09 录用日期: 2018-01-25 发布日期: 2018-04-04

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摘要

组织工程通过系统结合分子信号和力学信号对特定靶细胞进行有意可控刺激以组建新的组织,通常需要借助由生物材料构建的结构传递这些信号,并对生成的组织块塑形。这些结构之前被称为支架,如今被更准确地命名为模板,其规范却难以定义,主要因为该规范必须涉及为细胞组建新组织提供适宜的微环境,以及细胞与模板材料的相互作用符合构建新型可存活组织的需求。这些特点统称为生物相容性。然而,传统生物相容性的理论和公认机制(大多通过可移植的医学装置进行实验得出)不足以解释在组织工程过程中的现象。本文作者近期在特定的基于材料、生物学的途径方面重新定义了生物相容性。本文以上述途径为前提讨论了组织工程生物相容性的机制。

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