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《工程(英文)》 >> 2018年 第4卷 第5期 doi: 10.1016/j.eng.2018.07.021

面向医学应用的3D 打印技术现状综述

a State Key Laboratory of Materials Processing and Die and Mould Technology, Huazhong University of Science and Technology, Wuhan 430074, China
b Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, China
c Department of Clinical Science, University of Bergen, Bergen 5020, Norway

收稿日期: 2017-11-09 修回日期: 2018-02-25 录用日期: 2018-08-01 发布日期: 2018-08-04

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摘要

器官移植供体短缺一直是世界各国医学界面临的重大难题之一。传统方法不可避免地存在并发症、二次损伤和供体来源有限等潜在问题。3D 打印技术具有解决目前这些问题的潜力,可用于快速制造个性化组织工程支架、细胞原位修复组织缺陷,甚至直接打印组织和器官。打印的植入体和器官不仅与患者的受损组织完美匹配,而且能够调控材料微结构和细胞排列,促进细胞生长和分化。因此,这类植入体有望实现组织修复,甚至最终解决供体短缺问题。本文总结了3D 打印在医学领域相关研究和最新进展的四个层次,介绍了不同类型的生物医用材料,并讨论了医学应用中3D 打印所需材料和构建体外细胞质基质(ECM)存在的问题和未来的发展方向。

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