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《工程(英文)》 >> 2019年 第5卷 第1期 doi: 10.1016/j.eng.2018.11.013

肠道微生态——探索中药临床疗效的新思路

aState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China

bCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou 310003, China

收稿日期: 2018-06-09 修回日期: 2018-10-10 录用日期: 2018-11-15 发布日期: 2018-12-25

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摘要

自古以来,中药在疾病预防、症状缓解和健康改善等方面发挥了重要作用。然而,复杂的成分和尚未明确的机制阻碍了中药的广泛推广和应用。越来越多的研究表明,和人体健康息息相关的肠道微生态与中药的疗效有关,因此从肠道微生态的角度去探索中药可能是打开中药奥秘的金钥匙。肠道菌群主要通过以下4个生理途径中发挥作用:参与宿主代谢、调节系统免疫、维持胃肠道稳态以及影响脑功能和宿主行为。本文回顾了中药与慢性肝病、溃疡性结肠炎、肥胖和2型糖尿病等疾病之间的联系,从肠道微生态的角度阐明其潜在的机制。未来,我们需要进一步的研究和更完善的实验设计,以揭示中药与肠道菌群之间相互作用的具体机制,并为中药的创新研究提供新的思路。

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