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《工程(英文)》 >> 2021年 第7卷 第5期 doi: 10.1016/j.eng.2020.01.017

益生菌对非酒精性脂肪性肝病疗效的研究进展

a State Key Laboratory for Diagnosis and Treatment of Infectious Disease, National Clinical Research Center for Infectious Disease, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China
b Department of Clinical and Experimental Medicine, Linköping University, Linköping SE 581 83, Sweden

# These authors contributed equally to this work.

收稿日期: 2019-12-05 修回日期: 2020-01-06 录用日期: 2020-01-12 发布日期: 2020-10-08

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摘要

非酒精性脂肪性肝病(NAFLD)在全球范围内的患病率高达20%~33%,已成为严重威胁人类健康的慢性肝病之一。至今为止,除了改变生活方式,改善NAFLD尚无明确的药物治疗方法。因此,找到有效、可替代的干预策略迫在眉睫。随着人们对肠道微生态在NAFLD发病机制中的重要作用的认识,益生菌防治NAFLD的研究也随之增多。NAFLD治疗中最受关注的益生菌主要包括以双歧杆菌属(Bifidobacterium)和乳酸杆菌属(Lactobacillus)为代表的传统益生菌,以及下一代新兴益生菌(NGP),如嗜黏蛋白阿克曼菌(Akkermansia muciniphila)和普拉梭菌(Faecalibacterium prausnitzii)等。本文综述了口服传统益生菌和NGP对NAFLD发生发展的影响;基于最新的动物和临床研究,阐述了益生菌直接或间接影响疾病的机制。虽然相关研究已有很多,但要全面了解益生菌、肠道微生态、NAFLD之间的具体潜在机制,仍需要深入研究,需要更多的大规模临床试验来评估益生菌治疗NAFLD的效果以及益生菌在人体内的安全性。

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