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《工程(英文)》 >> 2021年 第7卷 第7期 doi: 10.1016/j.eng.2020.05.021

可见光引发的3D 生物打印技术及其生物墨水材料在组织工程领域的研究进展

a Centre for Translational Medicine Research and Development, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
b Key Laboratory of Health Informatics, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
c AO Research Institute, Davos CH-7270, Switzerland
d Musculoskeletal Research Laboratory, Department of Orthopedics and Traumatology, The Chinese University of Hong Kong, Hong Kong 999077, China
e Guangdong Engineering Laboratory of Biomaterials Additive Manufacturing, Shenzhen 518055, China

收稿日期: 2019-09-03 修回日期: 2020-05-23 录用日期: 2020-05-26 发布日期: 2020-09-30

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摘要

3D生物打印技术是一种基于传统3D打印技术发展起来的新兴技术。该技术可以把生物相容性材料、细胞或生物活性因子进行精准组装,为组织工程研究提供新方向。在众多3D生物打印技术中,光固化3D生物打印技术在组织工程研究领域发挥着重要作用,而光固化3D生物打印技术的成功应用又与生物材料的光固化特性不可分割。在可见光固化材料中,光交联水凝胶因聚合速度快、时间和结构可控的特点而极具研究价值和应用潜能。众所周知,光聚合反应通常由紫外线或可见光引发。然而,紫外线用于3D生物打印可能会造成细胞损伤,影响细胞的活力。而可见光在生物安全性方面具有独特的优势,所以,将可见光交联技术应用在3D生物打印领域极具应用前景。本文回顾了目前可应用的由可见光引发的3D生物打印技术,并对可见光交联生物墨水的交联机理、可见光引发剂类型和生物医学应用进行了介绍。本文最后对可见光引发的3D生物打印设备及水凝胶目前在生物医学领域应用中存在的挑战和前景进行了讨论。

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