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《工程(英文)》 >> 2020年 第6卷 第11期 doi: 10.1016/j.eng.2020.10.001

医用增材制造领域中的微流控技术

a Department of Rheumatology and Immunology, Institute of Translational Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China
b College of Artificial Intelligence, Nanjing Agricultural University, Nanjing 210031, China
c State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China

收稿日期: 2019-07-10 修回日期: 2020-01-23 录用日期: 2020-05-05 发布日期: 2020-10-08

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摘要

增材制造是食品、制药、医学和机械加工等领域的一种重要生产技术。得益于增材制造快速、低成本和可定制化的加工特性,医学增材制造推动了医疗器械、医学假体和临床移植物等领域的发展。在此背景下,高通量以及结构和组分把控精准等优势使微流控技术在医用增材制造领域显露头角,且已被应用于药物开发、组织工程和器官芯片的构建。本文综述了近年来微流控技术在医用增材制造领域的研究进展。首先,针对不同结构的液滴和纤维模板的构建,评估了基于微流控技术的医用增材制造的独特优势;其次,介绍了微流控技术在细胞定向、三维细胞培养、体外组织构建和细胞疗法方向的应用现状;最后,讨论了基于微流控技术的医用增材制造面临的挑战及其发展前景。

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