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《工程(英文)》 >> 2023年 第20卷 第1期 doi: 10.1016/j.eng.2021.11.013

麻醉与意识的脑网络研究进展——框架与临床应用

a Key Laboratory for Biomedical Engineering of Ministry of Education of China, Zhejiang University, Hangzhou 310007, China
b Department of Neurology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310020, China
c School of Electrical and Computer Engineering, National Technical University of Athens, Athens 15780, Greece
d Department of Control Science and Engineering, College of Electronics and Information Engineering, Tongji University, Shanghai 200092, China
e Department of Anesthesiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
f The N1 Institute for Health, Center for Life Sciences, National University of Singapore, Singapore 117456, Singapore

收稿日期: 2021-07-20 修回日期: 2021-10-21 录用日期: 2021-11-09 发布日期: 2021-12-13

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摘要

尽管麻醉与意识之间的关系一直是研究者关注的重点,但目前学界对于麻醉与意识的神经机制理解仍处在初级阶段,极大地限制了麻醉监测和意识评估系统的进一步发展。此外,现有麻醉监测方法难以提供足够的有效信息,对精准麻醉监测的目标构成了障碍。近年来,使用脑网络分析揭示麻醉机制已成为研究热点,其目的是为临床应用提供新的研究思路。针对这一新的研究趋势,本文全面回顾了麻醉相关脑网络研究的最新进展,系统地比较了麻醉和意识的几种潜在的神经机制以及不同层面大脑神经活动的测量方法;从皮层碎片化理论出发,介绍了连通性和网络分析的一些重要的研究方法和相关成果;在总结归纳现有研究成果的基础上,论证了全脑多模态网络数据可以提供现有麻醉监测方法所无法提供的信息;更重要的是,进一步探讨简化脑网络分析方法的可行性,这一方法将会在优化现有的临床麻醉监测系统中发挥重要作用。

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