2013, Volume 7, Issue 1
Frontiers of Medicine >> 2013, Volume 7, Issue 1 doi: 10.1007/s11684-013-0246-6
Primary hypertrophic osteoarthropathy: an update
1. Metabolic Bone Disease and Genetic Research Unit, Department of Osteoporosis and Bone Diseases, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China;
2. Department of Orthopedic Surgery, Shanghai Jiao Tong University Affliated Sixth People’s Hospital, Shanghai 200233, China
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Abstract
Digital clubbing, which has been recognized as a sign of systemic disease, is one of the most ancient diseases. However, the pathogenesis of clubbing and hypertrophic osteoarthropathy has hitherto been poorly understood. The study of a clinically indistinguishable idiopathic form (primary hypertrophic osteoarthropathy, PHO) provides an opportunity to understand the pathogenesis of hypertrophic osteoarthropathy. Current advances in the study of PHO are discussed. The impaired metabolism of prostaglandin E2 (PGE2) plays a central role in its pathogenesis.
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