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Frontiers of Medicine >> 2014, Volume 8, Issue 2 doi: 10.1007/s11684-014-0328-0

Can intravesical bacillus Calmette-Guérin reduce recurrence in patients with non-muscle invasive bladder cancer? An update and cumulative meta-analysis

1. The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China.

2. Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China

Available online: 2014-05-21

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Approximately 70% of newly diagnosed bladder tumors are non-muscle invasive bladder cancer (NMIBC). NMIBC accounts for approximately 80% of total bladder cancer cases. Bacillus Calmette-Guérin (BCG) instillation and maintenance is considered as the standard adjuvant treatment for superficial bladder cancer. A number of randomized studies have focused on the benefit of maintenance therapy following initial BCG induction. To provide further insights into the effect of intravesical instillation on recurrence in patients with NMIBC, we analyzed this relationship by conducting an updated detailed meta-analysis. Evidence suggested that adjuvant intravesical BCG with maintenance treatment is significantly effective for the prophylaxis of tumor recurrence in patients with NMIBC.

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