2015, Volume 9, Issue 1
Frontiers of Medicine >> 2015, Volume 9, Issue 1 doi: 10.1007/s11684-014-0345-z
A case of primary neuroendocrine breast carcinoma that responded to neo-adjuvant chemotherapy
1. Department of Pathology, Cancer Hospital of Shantou University Medical College, Shantou 515031, China.
2. Cancer Research Center, Shantou University Medical College, Shantou 515031, China.
3. The Breast Center, Cancer Hospital of Shantou University Medical College, Shantou 515031, China.
4. Department of Pathology, Shantou University Medical College, Shantou 515031, China
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Abstract
Primary neuroendocrine breast carcinoma (NEBC) is a very rare type of breast cancer. Two characteristic biomarkers, namely, CgA and Syn, should be immunohistochemically detected to diagnose NEBC. In this study, a 43-year-old woman with a large mass of 8.3 cm × 2.9 cm in her right breast was reported. The patient was pathologically diagnosed with NEBC after specific markers, including CgA and Syn, as well as few differential markers, such as CK7, ER, PR, C-erbB-2, NSE, and E-cadherin, were immunohistochemically detected. The patient showed a remarkable response to four cycles of neo-adjuvant chemotherapy (partial response based on RECIST criteria) and sequentially underwent modified radical mastectomy. Moreover, the diagnosis and treatment of NEBC based on this case and available related literature were discussed.d literature were discussed.
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