2015, Volume 9, Issue 3
Frontiers of Medicine >> 2015, Volume 9, Issue 3 doi: 10.1007/s11684-015-0398-7
Severe hepatoxicity caused by aspirin overdose: a case report
1. Department of Nursing, School of Medicine, Shihezi University, Shihezi 832002, China.
2. Department of Pediatric Surgery, The Affiliated Northwest Women’s and Children’s Hospital, Xi’an Jiaotong University, Xi’an 710003, China.
3. Third Department of General Surgery, The First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi 832002, China.
4. Department of Medical Administration, The First Affiliated Hospital, Shihezi University, Shihezi 832002, China.
5. Department of Emergency, The First Affiliated Hospital, Shihezi University, Shihezi 832002, China
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Abstract
We report here the rare case of a 61-year-old man with multiple organ dysfunction caused by an aspirin overdose (4 g orally). The patient presented with a fever that reached 39.2 °C, a peptic ulcer, and massive upper gastrointestinal bleeding. His blood test results were as follows: white blood cell count, 1.8×109/L; absolute lymphocytes, 0.4×109/L; absolute neutrophils, 1.2×109/L; and electrolyte disturbances. A computed tomography (CT) scan showed evidence of bilateral inferior pulmonary infection and acute pancreatitis. Thick dark bile with visible floccule was drawn via a percutaneous transhepatic cholangiodrainage (PTCD). Klebsiella pneumoniae was detected in microbiological bile tests. Two years later, the patient died of chronic liver failure.
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