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Frontiers of Medicine >> 2019, Volume 13, Issue 2 doi: 10.1007/s11684-018-0630-3

design of novel proton-pump inhibitors with reduced adverse effects

. Department of Gastroenterology, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.. School of Biomedical Informatics, The University of Texas Health Science Center at Houston, 7000 Fannin St, Houston, TX 77030, USA;.. Digestive Diseases and Nutrition Center, Department of Pediatrics, The State University of New York at Buffalo, Buffalo, NY 14260, USA;.. Basic Medical College, Beijing University of Chinese Medicine, Beijing 100029, China;.. Genome, Environment and Microbiome Community of Excellence, The State University of New York at Buffalo, Buffalo, NY 14214, USA

Accepted: 2018-05-31 Available online: 2018-05-31

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The development of new proton-pump inhibitors (PPIs) with less adverse effects by lowering the pKa values of nitrogen atoms in pyrimidine rings has been previously suggested by our group. In this work, we proposed that new PPIs should have the following features: (1) number of ring II= number of ring I+ 1; (2) preferably five, six, or seven-membered heteroatomic ring for stability; and (3) 1

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