Mild and highly regioselective synthesis of biaryl acids via Rh(I)-catalyzed cross-dehydrogenative coupling of benzoic acids using sodium chlorite as oxidant

2018, Volume 12, Issue 1

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Frontiers of Chemical Science and Engineering >> 2018, Volume 12, Issue 1 doi: 10.1007/s11705-017-1693-4

Mild and highly regioselective synthesis of biaryl acids via Rh(I)-catalyzed cross-dehydrogenative coupling of benzoic acids using sodium chlorite as oxidant

. Department of Chemistry, FQRNT Center for Green Chemistry and Catalysis, McGill University, Montreal, Quebec, H3A0B8, Canada.. Department of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou 221116, China

Accepted: 2017-12-26 Available online: 2018-02-26

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Abstract

A mild and efficient synthesis for the biaryl acids via rhodium-catalyzed cross-dehydrogenative coupling reaction has been developed. This novel protocol with sodium chlorite as an oxidant featured many advantages such as mild reaction conditions, high regioselectivity, tolerance of various functional groups, and good to excellent yields.

Keywords

biaryl acids ; cross-dehydrogenative coupling ; rhodium-catalyzed

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