The horizontal stiffness of the isolated layer is reduced substantially by a friction pendulum bearing (FPB) toprotectthe structure from potential damages caused by earthquakes. However, horizontal stiffness is essential to progressive collapse resistance of structures. This paper presents a simplified model to assess the progressive collapse response of beam-pier substructure isolated by FPB. Progressive collapse resistance by flexural action of the beam and additional resistance owing to the horizontal restraining force was achieved. The influences of the equivalent radius and friction coefficient of the FPB, the applied axial force on the FPB, and span-depth ratio of the beam on the additional resistance were investigated. Simulations were conducted to verify the proposed model. The results show that progressive collapse resistance provided by horizontal restraining can be reduced as large as 46% and 88% during compressive arching action (CAA) and catenary action (CA), respectively. The equivalent radius of the FPB shows limited effect on the progressive collapse response of FPB isolated structures, but friction coefficient and applied axial force, as well as depth ratio of the beam, show significant influences on the additional progressive collapse resistance capacity. Finite element method (FEM) results are in good agreement with the result obtained by the proposed method.