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Engineering >> 2021, Volume 7, Issue 8 doi: 10.1016/j.eng.2020.07.029

Advances and Strategies for Controlling the Quality and Safety of Postharvest Fruit

a Key Laboratory of Plant Resources, Institute of Botany, Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing 100093, China
b Key Laboratory of Postharvest Handling of Fruits, Ministry of Agriculture, Beijing 100093, China
c University of Chinese Academy of Sciences, Beijing 100049, China

Received: 2019-11-08 Revised: 2020-02-28 Accepted: 2020-07-20 Available online: 2020-12-25

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Abstract

Fresh fruits are highly valued by consumers worldwide, owing to their delicious flavors, abundant nutrients, and health-promoting characteristics, and as such, fruits make up an important component of a healthy diet. The postharvest quality and safety of fresh fruit involve complex interactions among the fruit, environmental factors, and postharvest pathogens. Efficient regulation of fruit senescence and pathogen resistance, as well as disease-causing abilities of postharvest pathogens, is critical to understanding the fundamental mechanisms that underlie fruit quality and safety. This paper provides a comprehensive review of recent advances and currently available strategies for maintaining fruit quality and controlling major postharvest pathogens, mainly Botrytis cinerea and Penicillium expansum, which may promote sustainable and environmental-friendly development of the fruit industry.

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References

[ 1 ] Droby S, Wisniewski M, Macarisin D, Wilson C. Twenty years of postharvest biocontrol research: is it time for a new paradigm? Postharvest Biol Technol 2009;52(2):137–45. link1

[ 2 ] Tian SP, Qin GZ, Li BQ. Reactive oxygen species involved in regulating fruit senescence and fungal pathogenicity. Plant Mol Biol 2013;82(6):593–602. link1

[ 3 ] Statistics [Internet]. Rome: Food and Agriculture Organization of the United Nations; c2020 [cited 2019 Oct 1]. Available from: http://www.fao.org/ statistics/en/. link1

[ 4 ] Tian SP, Torres R, Ballester AR, Li BQ, Vilanova L, González-Candelas L. Molecular aspects in pathogen–fruit interactions: virulence and resistance. Postharvest Biol Technol 2016;122:11–21. link1

[ 5 ] Klee HJ, Giovannoni JJ. Genetics and control of tomato fruit ripening and quality attributes. Annu Rev Genet 2011;45(1):41–59. link1

[ 6 ] Lü PT, Yu S, Zhu N, Chen YR, Zhou BY, Pan Y, et al. Genome encode analyses reveal the basis of convergent evolution of fleshy fruit ripening. Nat Plants 2018;4(10):784–91. link1

[ 7 ] Prusky DB. Pathogen quiescence in postharvest disease. Annu Rev Phytopathol 1996;34(1):413–34. link1

[ 8 ] Gillaspy G, Ben-David H, Gruissem W. Fruits: a developmental perspective. Plant Cell 1993;5(10):1439–51. link1

[ 9 ] Sisler EC, Serek M. Inhibitors of ethylene responses in plants at the receptor level: recent developments. Physiol Plant 2006;100(3):577–82. link1

[10] Liu RL, Xu Y, Li BQ, Qin GZ, Tian SP. The role of 1-methylcyclopropene in lipid peroxidation, anti-oxidant enzyme activities, and ethylene biosynthesis in ‘Laiyang’ pear (Pyrus bretschneideri Rehd.) during fruit ripening. J Hortic Sci Biotechnol 2015;90(2):210–6. link1

[11] Zhang ZQ, Tian SP, Zhu Z, Xu Y, Qin GZ. Effects of 1-methylcyclopropene (1- MCP) on ripening and resistance of jujube (Zizyphus jujuba cv. Huping) fruit against postharvest disease. LWT-Food Sci Technol 2012;45(1):13–9. link1

[12] Koukounaras A, Sfakiotakis E. Effect of 1-MCP prestorage treatment on ethylene and CO2 production and quality of ‘Hayward’ kiwifruit during shelflife after short, medium and long term cold storage. Postharvest Biol Technol 2007;46(2):174–80. link1

[13] Jiang Y, Joyce DC, Terry LA. 1-methylcyclopropene treatment affects strawberry fruit decay. Postharvest Biol Technol 2001;23(3):227–32. link1

[14] Liu RL, Wang YY, Qin GZ, Tian SP. Molecular basis of 1-methylcyclopropene regulating organic acid metabolism in apple fruit during storage. Postharvest Biol Technol 2016;117:57–63. link1

[15] Giovannoni JJ. Fruit ripening mutants yield insights into ripening control. Curr Opin Plant Biol 2007;10(3):283–9. link1

[16] Vrebalov J, Ruezinsky D, Padmanabhan V, White R, Medrano D, Drake R, et al. A MADS-box gene necessary for fruit ripening at the tomato ripeninginhibitor (Rin) locus. Science 2002;296(5566):343–6. link1

[17] Ng TJ, Tigchelaar EC. Action of the non-ripening (nor) mutant on fruit ripening of tomato. J Am Soc Hortic Sci 1977;102:504–9. link1

[18] Manning K, Tör M, Poole M, Hong Y, Thompson AJ, King GJ, et al. A naturally occurring epigenetic mutation in a gene encoding an SBP-box transcription factor inhibits tomato fruit ripening. Nat Genet 2006;38(8):948–52. link1

[19] Barry CS, Giovannoni JJ. Ripening in the tomato Green-ripe mutant is inhibited by ectopic expression of a protein that disrupts ethylene signaling. Proc Natl Acad Sci USA 2006;103(20):7923–8. link1

[20] Lanahan MB, Yen HC, Giovannoni JJ, Klee HJ. The never ripe mutation blocks ethylene perception in tomato. Plant Cell 1994;6(4):521–30. link1

[21] Fujisawa M, Nakano T, Shima Y, Ito Y. A large-scale identification of direct targets of the tomato MADS box transcription factor RIPENING INHIBITOR reveals the regulation of fruit ripening. Plant Cell 2013;25(2):371–86. link1

[22] Qin GZ, Wang YY, Cao BH, Wang WH, Tian SP. Unraveling the regulatory network of the MADS box transcription factor RIN in fruit ripening. Plant J 2012;70(2):243–55. link1

[23] Wang YY, Wang WH, Cai JH, Zhang YR, Qin GZ, Tian SP. Tomato nuclear proteome reveals the involvement of specific E2 ubiquitin-conjugating enzymes in fruit ripening. Genome Biol 2014;15(12):548–67. link1

[24] Zhong SL, Fei ZJ, Chen YR, Zheng Y, Huang MY, Vrebalov J, et al. Single-base resolution methylomes of tomato fruit development reveal epigenome modifications associated with ripening. Nat Biotechnol 2013;31(2):154–9. link1

[25] Ito Y, Nishizawa-Yokoi A, Endo M, Mikami M, Shima Y, Nakamura N, et al. Reevaluation of the rin mutation and the role of RIN in the induction of tomato ripening. Nat Plants 2017;3(11):866–74. link1

[26] Li S, Xu H, Ju Z, Cao D, Zhu H, Fu D, et al. The RIN-MC fusion of MADS-box transcription factors has transcriptional activity and modulates expression of many ripening genes. Plant Physiol 2018;176(1):891–909. link1

[27] Wu J, Xu Z, Zhang Y, Chai L, Yi H, Deng X. An integrative analysis of the transcriptome and proteome of the pulp of a spontaneous late-ripening sweet orange mutant and its wild type improves our understanding of fruit ripening in citrus. J Exp Bot 2014;65(6):1651–71. link1

[28] Qin GZ, Zhu Z, Wang WH, Cai JH, Chen Y, Li L, et al. A tomato vacuolar invertase inhibitor mediates sucrose metabolism and influences fruit ripening. Plant Physiol 2016;172(3):1596–611. link1

[29] Cercós M, Soler G, Iglesias DJ, Gadea J, Forment J, Talón M. Global analysis of gene expression during development and ripening of citrus fruit flesh. A proposed mechanism for citric acid utilization. Plant Mol Biol 2006;62(4– 5):513–27. link1

[30] Wang J, Liu J, Chen K, Li H, He J, Guan B, et al. Comparative transcriptome and proteome profiling of two citrus sinensis cultivars during fruit development and ripening. BMC Genomics 2017;18(1):984. link1

[31] Chen JW, Zhang SL, Zhang LC. Sugar transport, metabolism, accumulation and their regulation in fruits. J Plant Physiol Mol Biol 2004;30(1):1–10. Chinese.

[32] Arena ME, Zuleta A, Dyner L, Constenla D, Ceci L, Curvetto N. Berberis buxifolia fruit growth and ripening: evolution in carbohydrate and organic acid contents. Sci Hortic 2013;158:52–8. link1

[33] Jia H, Jiu S, Zhang C, Wang C, Tariq P, Liu Z, et al. Abscisic acid and sucrose regulate tomato and strawberry fruit ripening through the abscisic acidstress-ripening transcription factor. Plant Biotechnol J 2016;14(10):2045–65. link1

[34] Gambetta GA, Matthews MA, Shaghasi TH, McElrone AJ, Castellarin SD. Sugar and abscisic acid signaling orthologs are activated at the onset of ripening in grape. Planta 2010;232(1):219–34. link1

[35] Zhu A, Li W, Ye J, Sun X, Ding Y, Cheng Y, et al. Microarray expression profiling of postharvest Ponkan mandarin (Citrus reticulata) fruit under cold storage reveals regulatory gene candidates and implications on soluble sugars metabolism. J Integr Plant Biol 2011;53(5):358–74. link1

[36] Chai YM, Jia HF, Li CL, Dong QH, Shen YY. FaPYR1 is involved in strawberry fruit ripening. J Exp Bot 2011;62(14):5079–89. link1

[37] Jia HF, Chai YM, Li CL, Lu D, Luo JJ, Qin L, et al. Abscisic acid plays an important role in the regulation of strawberry fruit ripening. Plant Physiol 2011;157 (1):188–99. link1

[38] Etienne A, Génard M, Lobit P, Mbeguié-A-Mbéguié D, Bugaud C. What controls fleshy fruit acidity? A review of malate and citrate accumulation in fruit cells. J Exp Bot 2013;64(6):1451–69. link1

[39] Yu K, Xu Q, Da X, Guo F, Ding Y, Deng X. Transcriptome changes during fruit development and ripening of sweet orange (Citrus sinensis). BMC Genomics 2012;13(1):10. link1

[40] Liu C, Long J, Zhu K, Liu L, Yang W, Zhang H, et al. Characterization of a citrus R2R3-MYB transcription factor that regulates the flavonol and hydroxycinnamic acid biosynthesis. Sci Rep 2016;6(1):25352. link1

[41] Huang D, Wang X, Tang Z, Yuan Y, Xu Y, He J, et al. Subfunctionalization of the Ruby2-Ruby1 gene cluster during the domestication of citrus. Nat Plants 2018;4(11):930–41. link1

[42] An JP, Zhang XW, You CX, Bi SQ, Wang XF, Hao YJ. MdWRKY40 promotes wounding-induced anthocyanin biosynthesis in association with MdMYB1 and undergoes MdBT2-mediated degradation. New Phytol 2019;224 (1):380–95. link1

[43] An JP, Wang XF, Zhang XW, Xu HF, Bi SQ, You CX, et al. An apple MYB transcription factor regulates cold tolerance and anthocyanin accumulation and undergoes MIEL1-mediated degradation. Plant Biotechnol J 2020;18 (2):337–53. link1

[44] Mittler R. ROS are good. Trends Plant Sci 2017;22(1):11–9. link1

[45] Brennan T, Frenkel C. Involvement of hydrogen peroxide in the regulation of senescence in pear. Plant Physiol 1977;59(3):411–6. link1

[46] Frenkel C, Eskin M. Ethylene evolution as related to changes in hydroperoxides in ripening tomato fruit. HortScience 1977;12:552–3. link1

[47] Warm E, Laties GG. Quantification of hydrogen peroxide in plant extracts by the chemiluminescence reaction with luminol. Phytochemistry 1982;21 (4):827–31. link1

[48] Qin GZ, Meng XH, Wang Q, Tian SP. Oxidative damage of mitochondrial proteins contributes to fruit senescence: a redox proteomics analysis. J Proteome Res 2009;8(5):2449–62. link1

[49] Meng XH, Han J, Wang Q, Tian SP. Changes in physiology and quality of peach fruits treated by methyl jasmonate under low temperature stress. Food Chem 2009;114(3):1028–35. link1

[50] Ding Y, Chang J, Ma Q, Chen L, Liu S, Jin S, et al. Network analysis of postharvest senescence process in citrus fruits revealed by transcriptomic and metabolomic profiling. Plant Physiol 2015;168(1):357–76. link1

[51] Wang Y, Ji DC, Chen T, Li BQ, Zhang ZQ, Qin GZ, et al. Production, signaling and scavenging mechanisms of reactive oxygen species in fruit-pathogen interactions. Int J Mol Sci 2019;20(12):2994. link1

[52] Chan ZL, Qin GZ, Xu XB, Li BQ, Tian SP. Proteome approach to characterize proteins induced by antagonist yeast and salicylic acid in peach fruit. J Proteome Res 2007;6(5):1677–88. link1

[53] Chan ZL, Wang Q, Xu XB, Meng XH, Qin GZ, Li BQ, et al. Functions of defenserelated proteins and dehydrogenases in resistance response induced by salicylic acid in sweet cherry fruits at different maturity stages. Proteomics 2008;8(22):4791–807. link1

[54] Wang Q, Lai TF, Qin GZ, Tian SP. Response of jujube fruits to exogenous oxalic acid treatment based on proteomic analysis. Plant Cell Physiol 2009;50 (2):230–42. link1

[55] Zhang L, Kars I, Essenstam B, Liebrand TWH, Wagemakers L, Elberse J, et al. Fungal endopolygalacturonases are recognized as microbe-associated molecular patterns by the arabidopsis receptor-like protein RESPONSIVENESS TO BOTRYTIS POLYGALACTURONASES1. Plant Physiol 2014;164(1):352–64. link1

[56] Weiberg A, Wang M, Lin FM, Zhao HW, Zhang ZH, Kaloshian I, et al. Fungal small RNAs suppress plant immunity by hijacking host RNA interference pathways. Science 2013;342(6154):118–23. link1

[57] Cai Q, Qiao LL, Wang M, He BY, Lin FM, Palmquist J, et al. Plants send small RNAs in extracellular vesicles to fungal pathogen to silence virulence genes. Science 2018;360(6393):1126–9. link1

[58] An B, Li BQ, Li H, Zhang ZQ, Qin GZ, Tian SP. Aquaporin8 regulates cellular development and reactive oxygen species production, a critical component of virulence in Botrytis cinerea. New Phytol 2015;209(4):1668–80. link1

[59] Li BQ, Peng HM, Tian SP. Attachment capability of antagonistic yeast Rhodotorula glutinis to Botrytis cinerea contributes to biocontrol efficacy. Front Microbiol 2016;7:601. link1

[60] Takemoto D, Tanaka A, Scott B. NADPH oxidases in fungi: diverse roles of reactive oxygen species in fungal cellular differentiation. Fungal Genet Biol 2007;44(11):1065–76. link1

[61] Segmüller N, Kokkelink L, Giesbert S, Odinius D, van Kan JA, Tudzynski P. NADPH oxidases are involved in differentiation and pathogenicity in Botrytis cinerea. Mol Plant Microbe Interact 2008;21(6):808–19. link1

[62] Siegmund U, Heller J, van Kan JAL, Tudzynski P. The NADPH oxidase complexes in Botrytis cinerea: evidence for a close association with the ER and the tetraspanin Pls1. PLoS ONE 2013;8(2):e55879. link1

[63] Minz Dub A, Kokkelink L, Tudzynski B, Tudzynski P, Sharon A. Involvement of Botrytis cinerea small GTPases BcRAS1 and BcRAC in differentiation, virulence, and the cell cycle. Eukaryot Cell 2013;12(12):1609–18. link1

[64] Li H, Zhang ZQ, He C, Qin GZ, Tian SP. Comparative proteomics reveals the potential targets of BcNoxR, a putative regulatory subunit of NADPH oxidase of Botrytis cinerea. Mol Plant Microbe Interact 2016;29(12):990–1003. link1

[65] Gourgues M, Brunet-Simon A, Lebrun MH, Levis C. The tetraspanin BcPls1 is required for appressorium-mediated penetration of Botrytis cinerea into host plant leaves. Mol Microbiol 2004;51(3):619–29. link1

[66] Julca I, Droby S, Sela N, Marcet-Houben M, Gabaldón T. Contrasting genomic diversity in two closely related postharvest pathogens: Penicillium digitatum and Penicillium expansum. Genome Biol Evol 2015;8(1):218–27. link1

[67] Li BQ, Zong YY, Du ZL, Chen Y, Zhang ZQ, Qin GZ, et al. Genomic characterization reveals insights into patulin biosynthesis and pathogenicity in Penicillium species. Mol Plant Microbe Interact 2015;28 (6):635–47. link1

[68] Chen Y, Li BQ, Xu XD, Zhang ZQ, Tian SP. The pH-responsive PacC transcription factor plays pivotal roles in virulence and patulin biosynthesis in Penicillium expansum. Environ Microbiol 2018;20(11):4063–78. link1

[69] Jurick WM, Peng H, Beard HS, Garrett WM, Lichtner FJ, Luciano-Rosario D, et al. Blistering1 modulates Penicillium expansum virulence via vesiclemediated protein secretion. Mol Cell Proteomics 2020;19(2):344–61. link1

[70] Tian SP. Microbial control of postharvest diseases of fruits and vegetables: current concepts and future outlook. In: Ray RC, Ward OP, editors. Microbial biotechnology in horticulture. Enfield: Science Publishers; 2006. p. 163–202. link1

[71] Wisniewski M, Wilson C, Droby S, Chalutz E, El Ghaouth A, Stevens C. Postharvest biocontrol: new concepts and applications. In: Vincent C, Goettel MS, Lazarovits G, editors. Biological control: a global perspective. Cambridge: CAB International; 2007. p. 262–73. link1

[72] Sharma RR, Singh D, Singh R. Biological control of postharvest diseases of fruits and vegetables by microbial antagonists: a review. Biol Control 2009;50 (3):205–21. link1

[73] Liu J, Sui Y, Wisniewski M, Droby S, Liu Y. Review: utilization of antagonistic yeasts to manage postharvest fungal diseases of fruit. Int J Food Microbiol 2013;167(2):153–60. link1

[74] Spadaro D, Droby S. Development of biocontrol products for postharvest diseases of fruit: the importance of elucidating the mechanisms of action of yeast antagonists. Trends Food Sci Technol 2016;47:39–49. link1

[75] Yu T, Li HY, Zheng XD. Synergistic effect of chitosan and Cryptococcus laurentii on inhibition of Penicillium expansum infections. Int J Food Microbiol 2007;114(3):261–6. link1

[76] Yu C, Zhou T, Sheng K, Zeng L, Ye C, Yu T, et al. Effect of pyrimethanil on Cryptococcus laurentii, Rhodosporidium paludigenum, and Rhodotorula glutinis biocontrol of Penicillium expansum infection in pear fruit. Int J Food Microbiol 2013;164(2–3):155–60. link1

[77] Zhang HY, Ma LC, Turner M, Xu HX, Zheng XD, Dong Y, et al. Salicylic acid enhances biocontrol efficacy of Rhodotorula glutinis against postharvest Rhizopus rot of strawberries and the possible mechanisms involved. Food Chem 2010;122(3):577–83. link1

[78] Zhang D, Spadaro D, Garibaldi A, Gullino ML. Potential biocontrol activity of a strain of Pichia guilliermondii against grey mold of apples and its possible modes of action. Biol Control 2011;57(3):193–201. link1

[79] Lahlali R, Hamadi Y, Drider R, Misson C, El Guilli M, Jijakli MH. Control of citrus blue mold by the antagonist yeast Pichia guilliermondii Z1: compatibility with commercial fruit waxes and putative mechanisms of action. Food Control 2014;45:8–15. link1

[80] Yan F, Xu S, Chen Y, Zheng X. Effect of rhamnolipids on Rhodotorula glutinis biocontrol of Alternaria alternata infection in cherry tomato fruit. Postharvest Biol Technol 2014;97:32–5. link1

[81] Zhang ZQ, Qin GZ, Li BQ, Tian SP. Effect of cinnamic acid for controlling gray mold on table grape and its possible mechanisms of action. Curr Microbiol 2015;71(3):396–402. link1

[82] Cai JH, Chen J, Lu GB, Zhao YM, Tian SP, Qin GZ. Control of brown rot on jujube and peach fruits by trisodium phosphate. Postharvest Biol Technol 2015;99:93–8. link1

[83] Ji DC, Chen T, Ma DY, Liu JL, Xu Y, Tian SP. Inhibitory effects of methyl thujate on mycelial growth of Botrytis cinerea and possible mechanisms. Postharvest Biol Technol 2018;142:46–54. link1

[84] Meng XH, Li BQ, Liu J, Tian SP. Physiological responses and quality attributes of table grape fruit to chitosan preharvest spray and postharvest coating during storage. Food Chem 2008;106(2):501–8. link1

[85] He C, Zhang ZQ, Li BQ, Xu Y, Tian SP. Effect of natamycin on Botrytis cinerea and Penicillium expansum—postharvest pathogens of grape berries and jujube fruit. Postharvest Biol Technol 2019;151:134–41. link1

[86] Ma DY, Ji DC, Zhang ZQ, Li BQ, Qin GZ, Xu Y, et al. Efficacy of rapamycin in modulating autophagic activity of Botrytis cinerea for controlling gray mold. Postharvest Biol Technol 2019;150:158–65. link1

[87] Wiemann P, Guo CJ, Palmer JM, Sekonyela R, Wang CCC, Keller NP. Prototype of an intertwined secondary-metabolite supercluster. Proc Natl Acad Sci USA 2013;110(42):17065–70. link1

[88] Bennett JW, Klich M. Mycotoxins. Clin Microbiol Rev 2003;16(3):497–516. link1

[89] Qin GZ, Tian SP, Chan ZL, Li BQ. Crucial role of antioxidant proteins and hydrolytic enzymes in pathogenicity of Penicillium expansum: analysis based on proteomics approach. Mol Cell Proteomics 2007;6(3):425–38. link1

[90] Piqué E, Vargas-Murga L, Gómez-Catalán J, de Lapuente J, Llobet JM. Occurrence of patulin in organic and conventional apple-based food marketed in Catalonia and exposure assessment. Food Chem Toxicol 2013;60:199–204. link1

[91] Chalmers I, Clarke M. Commentary: the 1944 patulin trial: the first properly controlled multicentre trial conducted under the aegis of the British Medical Research Council. Int J Epidemiol 2004;33(2):253–60. link1

[92] Puel O, Galtier P, Oswald IP. Biosynthesis and toxicological effects of patulin. Toxins 2010;2(4):613–31. link1

[93] Artigot MP, Loiseau N, Laffitte J, Mas-Reguieg L, Tadrist S, Oswald IP, et al. Molecular cloning and functional characterization of two CYP619 cytochrome P450s involved in biosynthesis of patulin in Aspergillus clavatus. Microbiology 2009;155(Pt 5):1738–47. link1

[94] Banani H, Marcet-Houben M, Ballester AR, Abbruscato P, González-Candelas L, Gabaldón T, et al. Genome sequencing and secondary metabolism of the postharvest pathogen Penicillium griseofulvum. BMC Genomics 2016;17 (1):19. link1

[95] Tannous J, El Khoury R, Snini SP, Lippi Y, El Khoury A, Atoui A, et al. Sequencing, physical organization and kinetic expression of the patulin biosynthetic gene cluster from Penicillium expansum. Int J Food Microbiol 2014;189:51–60. link1

[96] Ballester AR, Marcet-Houben M, Levin E, Sela N, Selma-Lázaro C, Carmona L, et al. Genome, transcriptome, and functional analyses of Penicillium expansum provide new insights into secondary metabolism and pathogenicity. Mol Plant Microbe Interact 2015;28(3):232–48. link1

[97] Li BQ, Zong YY, Du ZL, Chen Y, Zhang ZQ, Qin GZ, et al. Genomic characterization reveals insights into patulin biosynthesis and pathogenicity in Penicillium species. Mol Plant Microbe Interact 2015;28 (6):635–47. link1

[98] Yu JJ, Chang PK, Ehrlich KC, Cary JW, Bhatnagar D, Cleveland TE, et al. Clustered pathway genes in aflatoxin biosynthesis. Appl Environ Microbiol 2004;70(3):1253–62. link1

[99] Li BQ, Chen Y, Zong YY, Shang YJ, Zhang ZQ, Xu XD, et al. Dissection of patulin biosynthesis, spatial control and regulation mechanism in Penicillium expansum. Environ Microbiol 2019;21(3):1124–39. link1

[100] Forouzan S, Madadlou A. Incidence of patulin in apple juices produced in west Azerbayjan Province, Iran. J Agric Sci Technol 2014;16:1613–22. link1

[101] Moss MO, Long MT. Fate of patulin in the presence of the yeast Saccharomyces cerevisiae. Food Addit Contam 2002;19(4):387–99. link1

[102] Stinson EE, Osman SF, Huhtanen CN, Billis DD. Disappearance of patulin during alcoholic fermentation of apple juice. Appl Environ Microbiol 1978;36 (4):620–2. link1

[103] Ferruz E, Loran S, Herrera M, Gimenez I, Bervis N, Barcena C, et al. Inhibition of Fusarium growth and mycotoxin production in culture medium and in maize kernels by natural phenolic acids. J Food Protect 2016;79(10):1753–8. link1

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