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2022, Vol.10, Issue.3

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During liver cancer progression, the body's regional immune response is the major force that remodels the tumor microenvironment. However, the inflammatory response resulting from inevitable ischemia and reperfusion injury may induce an immune-suppressive environment that favors tumor recurrence after liver transplantation. A comprehensive review in this special issue, "Immunology," summarizes the most recent evidence contributing to a complete picture of intrahepatic inflammatory and immune regulation for cancer recurrence after liver transplantation. The intrahepatic humoral microenvironment features an exacerbated inflammatory response promoting tumor growth, angiogenesis, invasiveness, and metastasis. In addition, the cellular microenvironment in the liver is characterized by the mobilization of regulatory immune cells that promote the escape of tumor cells from immune surveillance and elimination. This up-to-date depiction of regional immune regulation indicates potential immunologic biomarkers for post-transplant cancer recurrence, along with promising new immunotherapy.

Contents Volume 10 · Issue 3 · 2022. Pages 1-184 22 articles

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News & Highlights

Supersonic Travel Seeks an Encore

Sean O´Neill,

Engineering 2022, Volume 10, Issue 3,   Pages 1-3 doi:10.1016/j.eng.2022.01.004

Abstract 523 PDF 93

Space Tourism Begins to Take Off

Mitch Leslie

Engineering 2022, Volume 10, Issue 3,   Pages 4-6 doi:10.1016/j.eng.2022.01.005

Abstract 311 PDF 61

Machine Learning Produces Superhuman Chip Designs

Robert Pollie,

Engineering 2022, Volume 10, Issue 3,   Pages 7-9 doi:10.1016/j.eng.2022.01.006

Abstract 368 PDF 94

Views & Comments

A Vision of Materials Genome Engineering in China

Jianxin Xie, Yanjing Su, Dawei Zhang, Qiang Feng

Engineering 2022, Volume 10, Issue 3,   Pages 10-12 doi:10.1016/j.eng.2021.12.008

Abstract 906 PDF 380

Engineering Achievements

The Extremely Low Frequency Engineering Project for Underground Exploration

Jianxun Lu,Xianjun Zhuo,Yong Liu,Guoze Zhao,Qingyun Di,

Engineering 2022, Volume 10, Issue 3,   Pages 13-20 doi:10.1016/j.eng.2021.12.003

Abstract 620 PDF 121

Research

Immunology

The Dual Regulatory Roles of Macrophages in Acute Allogeneic Organ Graft Rejection Review

Liang Tan, Yinan Guo, Chang Feng, Yangxiao Hou, Xubiao Xie, Yong Zhao

Engineering 2022, Volume 10, Issue 3,   Pages 21-29 doi:10.1016/j.eng.2021.10.015

Abstract 1156 PDF 147

Chimeric Antigen Receptors and Regulatory T Cells: The Potential for HLA-Specific Immunosuppression in Transplantation Review

Sabrina Wright, Conor Hennessy, Joanna Hester, Fadi Issa

Engineering 2022, Volume 10, Issue 3,   Pages 30-43 doi:10.1016/j.eng.2021.10.018

Abstract 742 PDF 53

Diverse Roles of Immune Cells in Transplant Rejection and Immune Tolerance Review

Xiaojie Gan, Jian Gu, Zheng Ju, Ling Lu

Engineering 2022, Volume 10, Issue 3,   Pages 44-56 doi:10.1016/j.eng.2021.03.029

Abstract 706 PDF 90

Role of Intrahepatic Regional Immunity in Post-Transplant Cancer Recurrence Review

Jiang Liu,Chung Mau Lo,Kwan Man

Engineering 2022, Volume 10, Issue 3,   Pages 57-64 doi:10.1016/j.eng.2021.11.012

Abstract 749 PDF 45

In Vivo Development of Fetal Pig Kidneys in Mature Monkeys Under Clinically Approved Immunosuppressant Drugs Article

Tsuyoshi Takamura, Kenji Matsui, Naoto Matsumoto, Yatsumu Saito, Toshinari Fujimoto, Susumu Tajiri, Shuichiro Yamanaka, Kei Matsumoto, Akimitsu Kobayashi, Izumi Yamamoto, Hiroshi Sasaki, Haruyuki Hirayama, Hitomi Matsunari, Kazuaki Nakano, Hiroshi Nagashima, Akihiko Kiyoshi, Takao Kuroda, Makoto Inoue, Takeshi Miyawaki, Takashi Yokoo, Eiji Kobayashi

Engineering 2022, Volume 10, Issue 3,   Pages 65-73 doi:10.1016/j.eng.2022.02.001

Abstract 1076 PDF 94

Materials Genome Engineering

Two-Layer High-Throughput: Effective Mass Calculations Including Warping Article

Andrew Supka, Nicholas A. Mecholsky, Marco Buongiorno Nardelli, Stefano Curtarolo, Marco Fornari

Engineering 2022, Volume 10, Issue 3,   Pages 74-80 doi:10.1016/j.eng.2021.03.031

Abstract 410 PDF 60

High-Throughput Powder Diffraction Using White X-Ray Beam and a Simulated Energy-Dispersive Array Detector Article

Xiaoping Wang, Weiwei Dong, Peng Zhang, Haoqi Tang, Lanting Zhang, Tieying Yang, Peng Liu, Hong Wang, X.-D. Xiang

Engineering 2022, Volume 10, Issue 3,   Pages 81-88 doi:10.1016/j.eng.2021.05.023

Abstract 447 PDF 50

Data Centric Design: A New Approach to Design of Microstructural Material Systems Article

Wei Chen, Akshay Iyer, Ramin Bostanabad

Engineering 2022, Volume 10, Issue 3,   Pages 89-98 doi:10.1016/j.eng.2021.05.022

Abstract 349 PDF 90

Machine Learning-Assisted High-Throughput Virtual Screening for On-Demand Customization of Advanced Energetic Materials Article

Siwei Song, Yi Wang, Fang Chen, Mi Yan, Qinghua Zhang

Engineering 2022, Volume 10, Issue 3,   Pages 99-109 doi:10.1016/j.eng.2022.01.008

Abstract 983 PDF 168

Biomedical Engineering

Rotation of Biological Cells: Fundamentals and Applications Review

Tao Tang, Yoichiroh Hosokawa, Takeshi Hayakawa, Yo Tanaka, Weihua Li, Ming Li, Yaxiaer Yalikun

Engineering 2022, Volume 10, Issue 3,   Pages 110-126 doi:10.1016/j.eng.2020.07.031

Abstract 352 PDF 65

Review on Drug Regulatory Science Promoting COVID-19 Vaccine Development in China Review

Zhiming Huang, Zhihao Fu, Junzhi Wang

Engineering 2022, Volume 10, Issue 3,   Pages 127-132 doi:10.1016/j.eng.2022.01.001

Abstract 256 PDF 55

Artificial Intelligence

Analog Optical Computing for Artificial Intelligence Review

Jiamin Wu,Xing Lin,Yuchen Guo,Junwei Liu,Lu Fang,Shuming Jiao,Qionghai Dai,

Engineering 2022, Volume 10, Issue 3,   Pages 133-145 doi:10.1016/j.eng.2021.06.021

Abstract 643 PDF 236

Antibiotic Resistance

Molecular Epidemiology of Klebsiella pneumoniae from Clinical Bovine Mastitis in Northern Area of China, 2018–2019 Article

Shikai Song, Wenjuan He, Dawei Yang, Manar Benmouffok, Yao Wang, Jiyun Li, Chengtao Sun, Xiangbin Song, Shizhen Ma, Chang Cai, Shuangyang Ding, Congming Wu, Zhangqi Shen, Yang Wang,

Engineering 2022, Volume 10, Issue 3,   Pages 146-154 doi:10.1016/j.eng.2021.01.015

Abstract 546 PDF 95

Coronavirus Disease 2019

Ecological Barrier Deterioration Driven by Human Activities Poses Fatal Threats to Public Health due to Emerging Infectious Diseases Review

Dayi Zhang,Yunfeng Yang,Miao Li,Yun Lu,Yi Liu,Jingkun Jiang,Ruiping Liu,Jianguo Liu,Xia Huang,Guanghe Li,Jiuhui Qu,

Engineering 2022, Volume 10, Issue 3,   Pages 155-166 doi:10.1016/j.eng.2020.11.002

Abstract 233 PDF 72

Bifunctional Asymmetric Fabric with Tailored Thermal Conduction and Radiation for Personal Cooling and Warming Article

Yucan Peng, Hiang Kwee Lee, David S. Wu, Yi Cui

Engineering 2022, Volume 10, Issue 3,   Pages 167-173 doi:10.1016/j.eng.2021.04.016

Abstract 232 PDF 71

Rheumatoid Arthritis

Roles of Serum Amyloid A 1 Protein Isoforms in Rheumatoid Arthritis Article

Elaine Lai-Han Leung, Huan-Ling Lai, Run-Ze Li, Hu-Dan Pan, Ze-Bo Jiang, Ying Li, Fu-Gang Duan, Jia-Hui Xu, Yi-Zhong Zhang, A-Xi Shi, Chun-Li Wei, Fang-Yuan Zhang, Xiao-Jun Yao, Liang Liu

Engineering 2022, Volume 10, Issue 3,   Pages 174-182 doi:10.1016/j.eng.2020.08.018

Abstract 303 PDF 38

Corrigendum to “Research on DC protection strategy in multi-terminal hybrid HVDC System” [Engineering 7 (2021) 1064-1075] Corrigendum

Yuping Zheng, Jiawei He, Bin Li, Tonghua Wu, Wei Dai, Ye Li

Engineering 2022, Volume 10, Issue 3,   Pages 183-183 doi:10.1016/j.eng.2022.02.006

Abstract 305 PDF 42