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Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient

Frontiers of Medicine   Pages 596-609 doi: 10.1007/s11684-021-0868-z

Abstract: Sialic acid binding Ig-like lectin 10 (Siglec10) is a member of innate immune checkpoints that inhibitspublic databases containing 64 517 patients of 33 cancer types, we found that the expression of Siglec10In particular, Siglec10 was upregulated in patients with kidney renal clear cell carcinoma (KIRCIn 131 KIRC patients of our settings, Siglec10 was elevated in the tumor tissues of 83 (63.4%) patientsMoreover, higher level of Siglec10 was associated with advanced disease (stages III and IV) and worse

Keywords： innate immune checkpoint     Siglec10     kidney renal clear cell carcinoma    

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PM10 emissions from industrial coal-fired chain-grate boilers

Xinghua Li, Junzan Han, Lei Duan

Frontiers of Environmental Science & Engineering 2017, Volume 11, Issue 6, doi: 10.1007/s11783-017-0966-y

Abstract: The PM in the submicron mode for burning with raw coal contributes to 33%±10 % of PM emissions, much

Keywords： coal-fired chain-grate boiler     PM10     size distribution     particulate emission control devices    

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Effect of IL-10 on formation of foam cell induced by ox-LDL

WANG Fei, DAI Yalei, XU Ting, XU Bo, WANG Kaifeng

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 298-302 doi: 10.1007/s11684-008-0057-3

Abstract: In this study the effects of lipopolysaccharide (LPS) and interleukin-10 (IL-10) on the formation ofThe cells were further stimulated by ox-LDL, ox-LDL plus LPS, ox-LDL plus IL-10 and LPS.However, the significant elevation by LPS was abrogated when IL-10 was added.IL-10, an anti-inflammatory cytokine, can inhibit the effect of ox-LDL and LPS.The inhibitive effect of IL-10 is an important factor for delaying atherosclerosis processes.

Keywords： inflammatory     presence     interleukin-10     dose-dependent     ox-LDL    

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The most influential “Top 10 Events” in carbon neutrality and climate change in 2022

Frontiers in Energy doi: 10.1007/s11708-023-0869-5

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Preface of special issue of the 10 th International Conference on CO 2 Utilization

Changjun LIU,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 2,   Pages 109-109 doi: 10.1007/s11705-009-0258-6

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Cross-sectional prevalence and pattern of non-anaemia severe malaria among 2–10 year olds in Sokoto in

Frontiers of Medicine   Pages 969-974 doi: 10.1007/s11684-021-0912-z

Abstract: A cross-sectional study was conducted among 2–10-year-old children in Sokoto, in August and Decemberto determine the endemicity of malaria based on Plasmodium falciparum prevalence rate (PfPR2-10higher than expected (2.6%), considering the endemicity pattern which was mesoendemic based on a PfPR2-10

Keywords： severe malaria     nigeria     malaria mortality     PfPR2-10     intermediate malaria transmission    

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GENOME EDITING: A GROUND BREAKING RESEARCH HAS BEEN RANKED TOP 10 ENGINEERING FRONTS FROM 2017 TO 2021

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 2,   Pages 309-311 doi: 10.15302/J-FASE-2022440

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Osteopontin is a promoter for hepatocellular carcinoma metastasis: a summary of 10 years of studies

Lunxiu Qin

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 24-32 doi: 10.1007/s11684-014-0312-8

Abstract:

In this review, we summarize the novel findings from our series of studies on the leading metastasis-related gene, osteopontin (OPN). In our previous gene expression profiling study, OPN was identified as one of the leading genes associated with the metastasis of hepatocellular carcinoma (HCC). We focused on OPN to evaluate its prognostic values and important roles in HCC metastasis. A retrospective study of large cohorts of HCC patients demonstrated that plasma OPN level was one of the leading independent prognostic factors for HCC patients, even in the early stage of HCC, and could serve as a surrogate serologic biomarker for monitoring the treatment response and tumor recurrence after HCC resection. Using both in vitro and in vivoinvestigations, we found that OPN has an important role in metastasis and tumor growth of HCC and is an attractive potential therapeutic target for combating HCC metastasis. We also found that OPN+ HCC cells have much more amplifications at chromosomal regions, and promoter polymorphisms are important in the regulation of OPN expression and tumor growth and lung metastasis of HCC.

Keywords： osteopontin (OPN)     hepatocellular carcinoma     metastasis     prognosis     therapeutic target     biomarker     genetic polymorphism    

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NES1/KLK10 and hNIS gene therapy enhanced iodine-131 internal radiation in PC3 proliferation

Jiajia Hu, Wenbin Shen, Qian Qu, Xiaochun Fei, Ying Miao, Xinyun Huang, Jiajun Liu, Yingli Wu, Biao Li

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 646-657 doi: 10.1007/s11684-018-0643-y

Abstract: gene is thought to be a tumor-suppressor gene. Our previous study found that overexpression of gene in PC3 cell line could slow down the tumor proliferation rate, associated with a mild decrease in expression. The decrease could increase the sensitivity of radiotherapy to tumors. Thus, we supposed to have an “enhanced firepower” effect by combining overexpressed gene therapy and I radiation therapy uptake by overexpressed hNIS protein. We found a weak endogenous expression of hNIS protein in PC3 cells and demonstrated that the low expression of hNIS protein in PC3 cells might be the reason for the low iodine uptake. By overexpressing in PC3, the radioactive iodine uptake ability was significantly increased. Results of and tumor proliferation experiments and F-fluorothymidine ( F-FLT) micro-positron emission tomography/computed tomography (micro-PET/CT) imaging showed that the combined gene therapy and I radiation therapy mediated by overexpressed hNIS protein had the best tumor proliferative inhibition effect. Immunohistochemistry showed an obvious decrease of expression and the lowest expression. These data suggest that via inhibition of expression, overexpressed might enhance the effect of radiation therapy of I uptake in overexpressed PC3 cells.

Keywords： androgen-independent prostate cancer     normal epithelial cell-specific 1/kallikrein 10     sodium/iodide symporter    

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Annexin A2-S100A10 heterotetramer is upregulated by PML/RARα fusion protein and promotes plasminogen-dependent

Dan Huang, Yan Yang, Jian Sun, Xiaorong Dong, Jiao Wang, Hongchen Liu, Chengquan Lu, Xueyu Chen, Jing Shao, Jinsong Yan

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 410-422 doi: 10.1007/s11684-017-0527-6

Abstract:

Aberrant expression of annexin A2-S100A10 heterotetramer (AIIt) associated with PML/RARα fusion, and resultant increases in ANXA2 transcripts and translational expressions of both ANXA2 and S100A10, while S100A10 transcripts remained constitutive.subunit, although S100A10 transcripts remained constitutive.RARα fusion protein transactivated the ANXA2 promoter to upregulate ANXA2 and accumulate S100A10

Keywords： annexin A2-S100A10 heterotetramer     PML/RARα fusion protein     plasmin     cell invasion     acute promyelocytic leukemia    

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Scientific publications on systematic review and meta-analysis from Chinese authors: a 10-year survey

Zhiping Yang, Qiong Wu, Kaichun Wu, Daiming Fan

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 94-99 doi: 10.1007/s11684-012-0181-y

Abstract:

Systematic reviews and meta-analyses are playing an increasingly important role in clinical research and practice. This study aimed to measure the scientific production of systematic review and meta-analysis from the three major regions of China: the Mainland (ML), Hong Kong (HK), and Taiwan (TW). English articles on systematic review and meta-analysis from ML, HK, and TW from 2001 to 2010 were retrieved from the PubMed database. The total number of articles, impact factors (IF), and articles published in high-impact journals were conducted for quantity and quality comparisons among the three regions. There were 1 587 published articles from ML (1 292), HK (203), and TW (92) during the past ten years. The annual total numbers of articles in the three regions increased significantly from 2001 to 2010 (from 13 to 677). The number of articles from ML has exceeded that from TW since 2001, and surpassed that from HK in 2003. The accumulated IF of articles from ML (3 488.24) was higher than those from HK (493.16) and TW (216.39). HK had the highest average IF of 3.31, followed by ML of 2.90 and TW of 2.85. Researchers from HK published a larger proportion of papers in high-impact journals than those from ML and TW. The Cochrane Database of Systematic Reviews was the most popular journal in China. Chinese authors have been very active to enhance the systematic review and meta-analysis research over the past ten years, especially in ML. The gap between ML and the other two regions has been narrowed. But there is still considerable room for Chinese authors to improve their studies on systematic review and meta-analysis.

Keywords： systematic review     meta-analysis     China     Chinese     impact factor    

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Analysis and Insights from the MIT Technology Review “Top 10 Breakthrough Technologies” in the Past Six

Tu Hailing,Sun Zongtan,Yao Yuan and Xu Yuan

Strategic Study of Chinese Academy of Engineering 2017, Volume 19, Issue 5,   Pages 85-91 doi: 10.15302/J-SSCAE-2017.05.015

Abstract:

The MIT Technology Review has published "the world's top 10

Keywords： technology review     “top 10 breakthrough technologies”     commerce     industry     society    

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A spectrometer for measuring particle size distributions in the range of 3 nm to 10 μm

Jieqiong LIU,Jingkun JIANG,Qiang ZHANG,Jianguo DENG,Jiming HAO

Frontiers of Environmental Science & Engineering 2016, Volume 10, Issue 1,   Pages 63-72 doi: 10.1007/s11783-014-0754-x

Abstract: and aerodynamic sizing was developed to measure aerosol size distributions in the range of 3 nm to 10scanning mobility particle sizer (RSMPS, 40 – 700 nm), and an aerodynamic particle sizer (APS, 550 nm – 10A full spectrum in the size range of 3 nm to 10 μm was demonstrated by measuring aerosol generated using

Keywords： spectrometer     particle size distribution     electrical mobility     linear inversion     aerodynamic diameter    

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Catalysis and deactivation of montmorillonite K10 in the aryl O -glycosylation of glycosyl trichloroacetoimidates

Xiaoliu LI, Xinhao YAN, Zhiwei LI, Hua CHEN, Pingzhu ZHANG,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 3,   Pages 342-347 doi: 10.1007/s11705-009-0279-1

Abstract: The catalysis of montmorillonite K10 (MK10) for aryl -glycosylation of glycosyl trichloroacetimidatesIt was found that the catalyst MK10 is deactivated gradually in the recycle glycosylation.The results show that the eliminated trichloroacetamide molecule deposits on the MK10, which blocks andThe regeneration of the deactivated MK10 by calcination was studied preliminarily.

Keywords： photoelectron spectroscopy     adsorption-desorption     glycosylation     deactivated     diffraction    

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predictive value of chromosome 8p deletion for metastasis of hepatocellular carcinoma: a summary of works in 10

QIN Lunxiu, TANG Zhaoyou, GUAN Xinyuan, YE Qinghai, JIA Huliang, REN Ning

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 211-215 doi: 10.1007/s11684-008-0041-y

Abstract: Hepatocellular carcinoma (HCC) represents an extremely poor prognostic cancer, which is mainly due to the high frequency of metastasis/recurrence after surgical operation. Exploring the molecular mechanisms involved in HCC metastasis could be helpful in the prediction and early diagnosis of HCC recurrence and could also provide new therapeutic targets for HCC metastasis. In the recent decade, we analyzed the genomic aberrations of the clinical specimens, as well as the metastatic models and cell lines of human HCC to identify the genetic markers related to HCC metastasis and to verify their clinical values in the prediction and control of metastasis of HCC. Using the comparative genomic hybridization (CGH) technique, we compared the differences of chromosomal aberrations between primary HCC tumors and their matched metastatic lesions, and found that chromosome 8p deletions might contribute to HCC metastasis. This novel finding was further confirmed by comparison between nude mice models of HCC with different metastatic potentials. By the more sensitive genome-wide microsatellite analysis, 8p deletion was defined to 8p23.3 and 8p11.2, which are two likely regions harboring metastasis-related genes of HCC. Using ‘8p-specific’ microarrays, two novel metastatic suppressors ( and ) were identified, and were proven to suppress invasion and metastasis of HCC. Clinical studies indicate that 8p deletion detected in HCC or circulating plasma DNA of patients is a useful predictor for metastatic recurrence and prognosis, even for patients with early stage HCC. These novel findings are regarded as important advances in the study of the molecular mechanisms of HCC metastasis, which provide not only a holistic view on the molecular cytogenetic bases of HCC metastasis, but also candidate regions for further study to identify metastatic suppressor genes.

Keywords： sensitive genome-wide     prediction     genome-wide microsatellite     frequency     Hepatocellular carcinoma    

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Title Author Date Type Operation

Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient

Journal Article

PM10 emissions from industrial coal-fired chain-grate boilers

Xinghua Li, Junzan Han, Lei Duan

Journal Article

Effect of IL-10 on formation of foam cell induced by ox-LDL

WANG Fei, DAI Yalei, XU Ting, XU Bo, WANG Kaifeng

Journal Article

The most influential “Top 10 Events” in carbon neutrality and climate change in 2022

Journal Article

Preface of special issue of the 10 th International Conference on CO 2 Utilization

Changjun LIU,

Journal Article

Cross-sectional prevalence and pattern of non-anaemia severe malaria among 2–10 year olds in Sokoto in

Journal Article

GENOME EDITING: A GROUND BREAKING RESEARCH HAS BEEN RANKED TOP 10 ENGINEERING FRONTS FROM 2017 TO 2021

Journal Article

Osteopontin is a promoter for hepatocellular carcinoma metastasis: a summary of 10 years of studies

Lunxiu Qin

Journal Article

NES1/KLK10 and hNIS gene therapy enhanced iodine-131 internal radiation in PC3 proliferation

Jiajia Hu, Wenbin Shen, Qian Qu, Xiaochun Fei, Ying Miao, Xinyun Huang, Jiajun Liu, Yingli Wu, Biao Li

Journal Article

Annexin A2-S100A10 heterotetramer is upregulated by PML/RARα fusion protein and promotes plasminogen-dependent

Dan Huang, Yan Yang, Jian Sun, Xiaorong Dong, Jiao Wang, Hongchen Liu, Chengquan Lu, Xueyu Chen, Jing Shao, Jinsong Yan

Journal Article

Scientific publications on systematic review and meta-analysis from Chinese authors: a 10-year survey

Zhiping Yang, Qiong Wu, Kaichun Wu, Daiming Fan

Journal Article

Analysis and Insights from the MIT Technology Review “Top 10 Breakthrough Technologies” in the Past Six

Tu Hailing,Sun Zongtan,Yao Yuan and Xu Yuan

Journal Article

A spectrometer for measuring particle size distributions in the range of 3 nm to 10 μm

Jieqiong LIU,Jingkun JIANG,Qiang ZHANG,Jianguo DENG,Jiming HAO

Journal Article

Catalysis and deactivation of montmorillonite K10 in the aryl O -glycosylation of glycosyl trichloroacetoimidates

Xiaoliu LI, Xinhao YAN, Zhiwei LI, Hua CHEN, Pingzhu ZHANG,

Journal Article

predictive value of chromosome 8p deletion for metastasis of hepatocellular carcinoma: a summary of works in 10

QIN Lunxiu, TANG Zhaoyou, GUAN Xinyuan, YE Qinghai, JIA Huliang, REN Ning

Journal Article