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AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches

Megan A. Hatlen, Lan Wang, Stephen D. Nimer

Frontiers of Medicine 2012, Volume 6, Issue 3,   Pages 248-262 doi: 10.1007/s11684-012-0206-6

Abstract:

The AML1-ETO fusion transcription factor is generated by the t(8;21) translocation, which is presentBoth human and mouse models of AML have demonstrated that AML1-ETO is insufficient for leukemogenesispathogenetic insights that have been gained from identifying the various events that can cooperate with AML1-ETO to induce AML in vivo.We also discuss potential therapeutic strategies for t(8;21) positive AML that involve targeting the

Keywords： AML1-ETO     mouse model     leukemia     t(8     21)     pathway hits     mutation     hematopoiesis     Kasumi-1     CD34+    

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Homoharringtonine synergy with oridonin in treatment of t(8; 21) acute myeloid leukemia

Weina Zhang, Ying Lu, Tao Zhen, Xinjie Chen, Ming Zhang, Ping Liu, Xiangqin Weng, Bing Chen, Yueying Wang

Frontiers of Medicine 2019, Volume 13, Issue 3,   Pages 388-397 doi: 10.1007/s11684-018-0624-1

Abstract: Collaboration of c-KIT mutations with AML1–ETO (AE) has been demonstrated to induce t(8; 21) acute myeloidleukemia (AML).therapies designed to eliminate AE and c-KIT oncoproteins may facilitate effective treatment of t(8; 21) AMLfeatures activity against tumor cells harboring c-KIT mutations, whereas oridonin can induce t(8; 21) AMLHHT increased intracellular oridonin concentration by modulating the expressions of MRP1 and MDR1, thus

Keywords： AML1–ETO     c-KIT     homoharringtonine     oridonin     t(8     21) AML     synergistic effect    

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Venetoclax and low-dose cytarabine induced complete remission in a patient with high-risk acute myeloid leukemia: a case report

Bingshan Liu, Roshni Narurkar, Madhura Hanmantgad, Wahib Zafar, Yongping Song, Delong Liu

Frontiers of Medicine 2018, Volume 12, Issue 5,   Pages 593-599 doi: 10.1007/s11684-018-0635-y

Abstract: combination therapies have not resulted in considerable progress in the treatment of acute myeloid leukemia (AMLElderly patients with AML and poor risk factors have grave prognosis.Midostaurin has been recently approved for the treatment of FLT-3-mutated AML.Here, we present a case of a male patient with poor performance status and who developed AML followingThe patient with high risk AML achieved complete response to the combined treatment regimen of low-dose

Keywords： venetoclax     cytarabine     AML     leukemia    

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Analysis of GM（1，1）Model and Its Application in Fire Risk Prediction

Chen Zijin,Wang Fuliang,Lu Shouxiang

Strategic Study of Chinese Academy of Engineering 2007, Volume 9, Issue 5,   Pages 91-94

Abstract:

Theoretical analysis of grey prediction model GM(1, 1) is present inMonotonicity of predicted value and its variation tendency predicted by GM(1, 1)model is proved.the monotonicity of predicted value and its variation tendency,  applicability criterion of GM(1,1) is brought forward.

Keywords： fire forecast     GM(1     1)     rate of the fire injured    

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geological recognition breakthrough in Liaodong zone, which leading to the discovery of the large oilfield JX1-recognition breakthrough in Liaodong zone, which leading to the discovery of the large oilfield JX1-1

Deng Yunhua

Strategic Study of Chinese Academy of Engineering 2011, Volume 13, Issue 10,   Pages 13-18

Abstract: According to this guidance, such giant oilfield JX1-1 was discovered with 150 million reserves in the

Keywords： Bohai Liaodong zone     JX1-1     geological recognition     large oilfield    

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Visual knowledge guided intelligent generation of Chinese seal carving Research Article

Kejun ZHANG, Rui ZHANG, Yehang YIN, Yifei LI, Wenqi WU, Lingyun SUN, Fei WU, Huanghuang DENG, Yunhe PAN

Frontiers of Information Technology & Electronic Engineering 2022, Volume 23, Issue 10,   Pages 1479-1493 doi: 10.1631/FITEE.2100094

Abstract:

We digitally reproduce the process of resource collaboration, design creation, and visual presentation of Chinese art. We develop an intelligent art-generation system (Zhejiang University Intelligent System, http://www.next.zju.edu.cn/seal/; the website of the search and layout system is http://www.next.zju.edu.cn/seal/search_app/) to deal with the difficulty in using a visual knowledge guided approach. The knowledge base in this study is the Qiushi Database, which consists of open datasets of images of seal characters and seal stamps. We propose a seal character generation method based on visual knowledge, guided by the database and expertise. Furthermore, to create the layout of the seal, we propose a deformation algorithm to adjust the seal characters and calculate layout parameters from the database and knowledge to achieve an intelligent structure. Experimental results show that this method and system can effectively deal with the difficulties in the generation of seal carving. Our work provides theoretical and applied references for the rebirth and innovation of art.

Keywords： Seal-carving     Intelligent generation     Deep learning     Parametric modeling     Computational art    

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Non-equidistant GM(1,1) power model and its application in engineering

Wang Zhengxin,Dang Yaoguo,Liu Sifeng

Strategic Study of Chinese Academy of Engineering 2012, Volume 14, Issue 7,   Pages 98-102

Abstract: text-align: justify;">Aiming at the problem of modeling for non-equidistant sequence, the non-equidistant GM(1,1The results showed that the form of non equidistant GM(1,1) power model was more flexible than the traditionalBoth non equidistant GM(1,1) model and Grey Verhulst model were the special cases of non equidistantGM(1,1) power model.shows modeling accuracy in traditional modeling, which was significantly improved by non equidistant GM(1,1

Keywords： grey system     non-equidistant sequence     GM(1     1) power model     parameter optimization    

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Band-gap tunable (GaxIn1−x)2O3 layer Research Articles

Fabi Zhang, Jinyu Sun, Haiou Li, Juan Zhou, Rong Wang, Tangyou Sun, Tao Fu, Gongli Xiao, Qi Li, Xingpeng Liu, Xiuyun Zhang, Daoyou Guo, Xianghu Wang, Zujun Qin,zhangfabi@outlook.com,qinzj@guet.edu.cn

Frontiers of Information Technology & Electronic Engineering 2021, Volume 22, Issue 10,   Pages 1370-1378 doi: 10.1631/FITEE.2000330

Abstract: Multicomponent oxide (GaIn)O films are prepared on (0001) sapphire substrates to realize a tunable band-gap by technology followed by thermal annealing. The optical properties and band structure evolution over the whole range of compositions in ternary compounds (GaIn)O are investigated in detail. The X-ray diffraction spectra clearly indicate that (GaIn)O films with Ga content varying from 0.11 to 0.55 have both cubic and monoclinic structures, and that for films with Ga content higher than 0.74, only the monoclinic structure appears. The transmittance of all films is greater than 86% in the visible range with sharp absorption edges and clear fringes. In addition, a blue shift of ultraviolet absorption edges from 380 to 250 nm is noted with increasing Ga content, indicating increasing band-gap energy from 3.61 to 4.64 eV. The experimental results lay a foundation for the application of transparent conductive compound (GaIn)O thin films in photoelectric and photovoltaic industry, especially in display, light-emitting diode, and solar cell applications.

Keywords： (GaxIn1−x)2O3薄膜；带隙可调谐；磁控溅射    

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Review of compact computational spectral information acquisition systems Review Articles

Hongya Song, Wenyi Zhang, Haifeng Li, Xu Liu, Xiang Hao,haox@zju.edu.cn

Frontiers of Information Technology & Electronic Engineering 2020, Volume 21, Issue 8,   Pages 1119-1266 doi: 10.1631/FITEE.1900266

Abstract: With the development of computer science, more and more hardware implementations can be reproduced by software programming, bringing compact, cheap, and fast components to imaging instrumentation. In recent years, computational methods have been introduced into spectral detection, and computational spectrum acquisition implementations have emerged. This paper highlights the advantages of computational spectrum acquisition implementations by comparing them with traditional non-computational methods. Then, focusing on the compact feature, we review the most representative implementations, and finally make discussion and offer an outlook.

Keywords： 光谱成像；计算成像；光谱仪    

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Soluble triggering receptor expressed on myeloid cell-1 (sTREM-1): a potential biomarker for the diagnosis

Changlin Cao, Jingxian Gu, Jingyao Zhang

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 169-177 doi: 10.1007/s11684-017-0505-z

Abstract: An example of these biomarkers is triggering receptor expressed on myeloid cell-1 (TREM-1), which isTREM-1 amplifies inflammation by activating the TREM-1/DAP12 pathway.Soluble TREM-1 (sTREM-1) is a special form of TREM-1 that can be directly tested in human body fluidsand well-known biomarker for infectious diseases. sTREM-1 level can be potentially used for the earlyTherefore, sTREM-1 is a feasible biomarker for the targeted therapy and rapid and early diagnosis of

Keywords： soluble triggering receptor expressed on myeloid cells-1     infectious diseases     diagnosis and prognosis    

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Copolymerization of 1-butene and 1-hexene with supported titanium catalyst

ZHAO Yongxian, SHAO Huafeng, WANG Bo, YAO Wei, HUANG Baochen

Frontiers of Chemical Science and Engineering 2007, Volume 1, Issue 3,   Pages 304-309 doi: 10.1007/s11705-007-0056-y

Abstract: With TiCl/MgCl (Ti) and Al(-Bu) (Al) as catalysts, the thermoplastic copolymer of 1-butene(Bt) and 1-The crystallization and stereoregularity of poly(1-butene) decreased with the addition of He.

Keywords： reaction     conversion     temperature     polymerization temperature     magnetic resonance    

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Traditional soliton erbium-doped fiber laser with InSe as saturable absorber Research

Xiaojuan Liu, Guomei Wang, Mingxiao Zhu, Kezhen Han, Wenfei Zhang, Huanian Zhang,zhangwenfei@sdut.edu.cn,huanian_zhang@163.com

Frontiers of Information Technology & Electronic Engineering 2021, Volume 22, Issue 3,   Pages 287-436 doi: 10.1631/FITEE.2000387

Abstract: Indium selenide (InSe) is a typical layered metal-chalcogenide semiconductor that has potential for developing ultrafast optoelectronic devices. In this work, InSe-polyvinyl alcohol (InSe-PVA) film is employed as saturable absorber and prepared by mixing InSe solution and polyvinyl alcohol solution. The nonlinear absorption properties of the InSe saturable absorber (InSe-SA) are investigated, showing that the nonsaturable absorption and modulation depth are 37.5% and 9.55%, respectively. lasers are generated in erbium-doped fiber (EDF) laser-employed InSe as a mode-locker. The central wavelength and pulse duration of the pulse are 1568.73 nm and 2.06 ps, respectively, under a repetition rate of 1.731 MHz. The maximum average output power is 16.4 mW at the pump power of 413 mW. To the best of our knowledge, this is the first demonstration of a pulse with InSe as a mode-locker. The experimental results further demonstrate that InSe is an outstanding nonlinear absorption material in ultrafast .

Keywords： 光纤激光器；纳米片；传统孤子    

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Molecular characterization of two suppressor of cytokine signaling 1 genes (

Xue XU,Jiannan ZHANG,Juan LI,Yajun WANG

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 1,   Pages 73-83 doi: 10.15302/J-FASE-2015044

Abstract: Suppressor of cytokine signaling 1 (SOCS1) protein can inhibit the signal transduction triggered by someamino acid protein, which shares high amino acid sequence identity (64%–67%) with human and mouse SOCS1.and cSOCS1a.and SOCS1b proteins can negatively regulate GH/PRL signaling.Taken together, these data suggest that both cSOCS1a and cSOCS1b may function as negative regulators

Keywords： chicken     SOCS1a     SOCS1b     growth hormone     prolactin    

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The Optimization of Grey Model GM (1,1)

Luo Dang,Liu Sifeng,Dang Yaoguo

Strategic Study of Chinese Academy of Engineering 2003, Volume 5, Issue 8,   Pages 50-53

Abstract:

This paper analyzes the reason that grey model GM (1,1) often makes errors in simulated data.By contrasting the optimum one to the GM (1,1) about the simulation, it can be concluded that the structuremethod of background value in grey model GM (1,1) has an important influence on the prediction and adaptabilityThe optimum background value makes grey model GM (1,1) have better fitting and forecasting precision.

Keywords： grey model GM (1     1)     winterization equation     background value    

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A review of optically induced rotation Review Article

Qi ZHU, Nan LI, Heming SU, Wenqiang LI, Huizhu HU,huhuizhu2000@zju.edu.cn

Frontiers of Information Technology & Electronic Engineering 2022, Volume 23, Issue 2,   Pages 171-185 doi: 10.1631/FITEE.2000338

Abstract: The optical rotation technique arose in the 1990s. brought an ideal platform for research on the of laser beams. For decades, the optical rotation technique has been widely applied in laboratory optical manipulation and the fields of biology and optofluidics. Recently, it has attracted much attention for its potential in the classical and quantum regimes. In this work, we review the progress of experiments and applications of . First, we introduce the basic exploration of . Then, we cover the development and application of optical rotation induced by orbital , and the spin is presented. Finally, we elaborate on recent applications of the optical rotation technique in high vacuum. As precise optical manipulation in a liquid medium enters its maturity, s in high vacuum open a new path for the high-speed .

Keywords： Optical tweezer     Optically induced rotation     Angular momentum     Micro-rotor    

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Title Author Date Type Operation

AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches

Megan A. Hatlen, Lan Wang, Stephen D. Nimer

Journal Article

Homoharringtonine synergy with oridonin in treatment of t(8; 21) acute myeloid leukemia

Weina Zhang, Ying Lu, Tao Zhen, Xinjie Chen, Ming Zhang, Ping Liu, Xiangqin Weng, Bing Chen, Yueying Wang

Journal Article

Venetoclax and low-dose cytarabine induced complete remission in a patient with high-risk acute myeloid leukemia: a case report

Bingshan Liu, Roshni Narurkar, Madhura Hanmantgad, Wahib Zafar, Yongping Song, Delong Liu

Journal Article

Analysis of GM（1，1）Model and Its Application in Fire Risk Prediction

Chen Zijin,Wang Fuliang,Lu Shouxiang

Journal Article

geological recognition breakthrough in Liaodong zone, which leading to the discovery of the large oilfield JX1-recognition breakthrough in Liaodong zone, which leading to the discovery of the large oilfield JX1-1

Deng Yunhua

Journal Article

Visual knowledge guided intelligent generation of Chinese seal carving

Kejun ZHANG, Rui ZHANG, Yehang YIN, Yifei LI, Wenqi WU, Lingyun SUN, Fei WU, Huanghuang DENG, Yunhe PAN

Journal Article

Non-equidistant GM(1,1) power model and its application in engineering

Wang Zhengxin,Dang Yaoguo,Liu Sifeng

Journal Article

Band-gap tunable (GaxIn1−x)2O3 layer

Fabi Zhang, Jinyu Sun, Haiou Li, Juan Zhou, Rong Wang, Tangyou Sun, Tao Fu, Gongli Xiao, Qi Li, Xingpeng Liu, Xiuyun Zhang, Daoyou Guo, Xianghu Wang, Zujun Qin,zhangfabi@outlook.com,qinzj@guet.edu.cn

Journal Article

Review of compact computational spectral information acquisition systems

Hongya Song, Wenyi Zhang, Haifeng Li, Xu Liu, Xiang Hao,haox@zju.edu.cn

Journal Article

Soluble triggering receptor expressed on myeloid cell-1 (sTREM-1): a potential biomarker for the diagnosis

Changlin Cao, Jingxian Gu, Jingyao Zhang

Journal Article

Copolymerization of 1-butene and 1-hexene with supported titanium catalyst

ZHAO Yongxian, SHAO Huafeng, WANG Bo, YAO Wei, HUANG Baochen

Journal Article

Traditional soliton erbium-doped fiber laser with InSe as saturable absorber

Xiaojuan Liu, Guomei Wang, Mingxiao Zhu, Kezhen Han, Wenfei Zhang, Huanian Zhang,zhangwenfei@sdut.edu.cn,huanian_zhang@163.com

Journal Article

Molecular characterization of two suppressor of cytokine signaling 1 genes (

Xue XU,Jiannan ZHANG,Juan LI,Yajun WANG

Journal Article

The Optimization of Grey Model GM (1,1)

Luo Dang,Liu Sifeng,Dang Yaoguo

Journal Article

A review of optically induced rotation

Qi ZHU, Nan LI, Heming SU, Wenqiang LI, Huizhu HU,huhuizhu2000@zju.edu.cn

Journal Article