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Dendritic cell vaccines in cancer immunotherapy: from biology to translational medicine

Hongmei Xu, Xuetao Cao

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 323-332 doi: 10.1007/s11684-011-0172-4

Abstract:

Cytokine storm and translating IL-6 biology into effective treatments for COVID-19

Frontiers of Medicine doi: 10.1007/s11684-023-1044-4

Abstract: As of May 3, 2023, the coronavirus disease 2019 (COVID-19) pandemic has resulted in more than 760 million confirmed cases and over 6.9 million deaths. Several patients have developed pneumonia, which can deteriorate into acute respiratory distress syndrome. The primary etiology may be attributed to cytokine storm, which is triggered by the excessive release of proinflammatory cytokines and subsequently leads to immune dysregulation. Considering that high levels of interleukin-6 (IL-6) have been detected in several highly pathogenic coronavirus-infected diseases, such as severe acute respiratory syndrome in 2002, the Middle East respiratory syndrome in 2012, and COVID-19, the IL-6 pathway has emerged as a key in the pathogenesis of this hyperinflammatory state. Thus, we review the history of cytokine storm and the process of targeting IL-6 signaling to elucidate the pivotal role played by tocilizumab in combating COVID-19.

Keywords: SARS-CoV-2     COVID-19     cytokine storm     interleukin-6     tocilizumab    

Designer enzyme for green materials innovation: Lactate-polymerizing enzyme as a key catalyst

Seiichi Taguchi

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 1,   Pages 139-142 doi: 10.1007/s11705-017-1636-0

Abstract: typical topic of synthetic biology.

Keywords: synthetic biology     enzyme evolutionary engineering     polyhydroxyalkanoate    

MicroRNAs and lung cancers: from pathogenesis to clinical implications

Ji Qi, David Mu

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 134-155 doi: 10.1007/s11684-012-0188-4

Abstract:

Lung cancer is the leading cause of cancer-related deaths in the US and worldwide. Better understanding of the disease is warranted for improvement in clinical management. Here we summarize the functions of small-RNA-based, posttranscriptional gene regulators, i.e. microRNAs, in the pathogenesis of lung cancers. We discuss the microRNAs that play oncogenic as well as tumor suppressive roles. We also touch on the value of microRNAs as markers for diagnosis, prognosis and the promising field of microRNA-based novel therapies for lung cancers.

Keywords: lung biology     lung cancer     microRNA    

Genome reprogramming for synthetic biology

Kylie Standage-Beier,Xiao Wang

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 1,   Pages 37-45 doi: 10.1007/s11705-017-1618-2

Abstract: ability to go from a digitized DNA sequence to a predictable biological function is central to synthetic biologydevelopment of new programmable tools to reengineer genomes has spurred myriad advances in synthetic biology

Keywords: CRISPR     genome engineering     synthetic biology     rational design    

Understanding channel tropism in traditional Chinese medicine in the context of systems biology

Ping Liu, Songlin Liu, Gang Chen, Ping Wang

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 277-279 doi: 10.1007/s11684-013-0273-3

Abstract: Results showed that this theory and systems biology have a similar holistic viewpoint.Systems biology could provide novel insights and platform in the study of channel tropism.

Keywords: systems biology     channel tropism theory     traditional Chinese medicine     application    

Recent advances in fruit crop genomics

Qiang XU,Chaoyang LIU,Manosh Kumar BISWAS,Zhiyong PAN,Xiuxin DENG

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 1,   Pages 21-27 doi: 10.15302/J-FASE-2014002

Abstract: In recent years, dramatic progress has been made in the genomics of fruit crops. The publication of a dozen fruit crop genomes represents a milestone for both functional genomics and breeding programs in fruit crops. Rapid advances in high-throughput sequencing technology have revolutionized the manner and scale of genomics in fruit crops. Research on fruit crops is encompassing a wide range of biological questions which are unique and cannot be addressed in a model plant such as . This review summarizes recent achievements of research on the genome, transcriptome, proteome, miRNAs and epigenome of fruit crops.

Keywords: fruit crops     fruit biology     gene function     genomics    

To Hold the Economical Time of Biology,to Practicea Positive View of Happiness

Gan Ziheng

Strategic Study of CAE 2007, Volume 9, Issue 2,   Pages 5-11

Abstract:

As predicted,the global economy is stepping into a so called "biological economy" by 2020, which can be explained as economy mainly dominated by biological technologies. The essay discusses the proposition, definition, classification and characteristic of biological economy, also, the importance of positive view of happiness in a biological economy condition and the reason for emphasizing people's happiness achieving,and the definition of happiness philosophy. It also discusses which views of happiness should be recommended and how to practice a positive view of happiness in the scientific and technological circle in China.

Keywords: biological economy     happiness     positive view of happiness    

Systems understanding of plant–pathogen interactions through genome-wide protein–protein interaction networks

Hong LI,Ziding ZHANG

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 2,   Pages 102-112 doi: 10.15302/J-FASE-2016100

Abstract: Plants are frequently affected by pathogen infections. To effectively defend against such infections, two major modes of innate immunity have evolved in plants; pathogen-associated molecular pattern-triggered immunity and effector-triggered immunity. Although the molecular components as well as the corresponding pathways involved in these two processes have been identified, many aspects of the molecular mechanisms of the plant immune system remain elusive. Recently, the rapid development of omics techniques (e.g., genomics, proteomics and transcriptomics) has provided a great opportunity to explore plant–pathogen interactions from a systems perspective and studies on protein–protein interactions (PPIs) between plants and pathogens have been carried out and characterized at the network level. In this review, we introduce experimental and computational identification methods of PPIs, popular PPI network analysis approaches, and existing bioinformatics resources/tools related to PPIs. Then, we focus on reviewing the progress in genome-wide PPI networks related to plant–pathogen interactions, including pathogen-centric PPI networks, plant-centric PPI networks and interspecies PPI networks between plants and pathogens. We anticipate genome-wide PPI network analysis will provide a clearer understanding of plant–pathogen interactions and will offer some new opportunities for crop protection and improvement.

Keywords: plant–pathogen interactions     systems biology     omics     plant immunity     protein–protein interaction     network    

Associations between

Haican Liu, Yuanyuan Zhang, Zhiguang Liu, Jinghua Liu, Yolande Hauck, Jiao Liu, Haiyan Dong, Jie Liu, Xiuqin Zhao, Bing Lu, Yi Jiang, Gilles Vergnaud, Christine Pourcel, Kanglin Wan

Frontiers of Medicine 2018, Volume 12, Issue 1,   Pages 92-97 doi: 10.1007/s11684-017-0610-z

Abstract:

Investigations on the genetic diversity of Mycobacterium tuberculosis in China have shown that Beijing genotype strains play a dominant role. To study the association between the M.?tuberculosis Beijing genotype and the drug-resistance phenotype, 1286 M. tuberculosis clinical isolates together with epidemiological and clinical information of patients were collected from the center for tuberculosis (TB) prevention and control or TB hospitals in Beijing municipality and nine provinces or autonomous regions in China. Drug resistance testing was conducted on all the isolates to the four first-line anti-TB drugs (isoniazid, rifampicin, streptomycin, and ethambutol). A total of 585 strains were found to be resistant to at least one of the four anti-TB drugs. The Beijing family strains consisted of 499 (53.20%) drug-sensitive strains and 439 (46.80%) drug-resistant strains, whereas the non-Beijing family strains comprised 202 (58.05%) drug-sensitive strains and 146 (41.95%) drug-resistant strains. No significant difference was observed in prevalence (c2=2.41, P>0.05) between the drug-resistant and drug-sensitive strains among the Beijing family strains. Analysis of monoresistance, multidrug-resistant TB, and geographic distribution of drug resistance did not find any relationships between the M.?tuberculosis Beijing genotype and drug-resistance phenotype in China. Results confirmed that the Beijing genotype, the predominant M. tuberculosis genotype in China, was not associated with drug resistance.

Keywords: tuberculosis     drug resistance     genotype     molecular biology    

Comparative lipidomic analysis of

Bin QIAO, Hong-Chi TIAN, Ying-Jin YUAN

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 4,   Pages 461-469 doi: 10.1007/s11705-012-1223-3

Abstract: Variations in the composition and level of phospholipids (PLs) in yeast cells during industrial ethanol fermentation processes were analyzed. A comparative lipidomic method was used to investigate the changes in total cellular PLs during continuous and fed-batch/batch processes. The phospholipid metabolism in yeast changed during both processes, mainly due to the presence of long-chain poly unsaturated fatty acids (PUFA) that contained phosphatidyglycerol (PG), phosphatidylethanolamine (PE) and phosphatidylserine (PS). The complexity of the media affected the growth of the yeast and the membrane composition. Yeast incorporated lots of exogenous saturated and PUFAs from the feedstock during the fermentations. During the continuous fermentation, there was an increase in PLs with shorter chains as the fermentation progressed and early in process there were more long-chains. During the fed-batch/batch process, the PG species increased as the fermentation progressed. This is probably due to an inositol deficiency in the earlier part of the fermentation.

Keywords: lipidomics     systems biology     phospholipids     stirred-tank     saccharomyces cerevisiae     biorefinery    

Mobile CRISPR-Cas9 based anti-phage system in E. coli

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 8,   Pages 1281-1289 doi: 10.1007/s11705-022-2141-7

Abstract: Escherichia coli is one of the most important microbial cell factories, but infection by bacteriophages in the environment may have a huge impact on its application in industrial production. Here, we developed a mobile CRISPR-Cas9 based anti-phage system for bacteriophages defense in E. coli. Two conjugative plasmids pGM1 (phosphoglucomutase 1) and pGM2 carrying one and two guide RNAs, respectively, were designed to defend against a filamentous phage. The results showed that the pGM1 and pGM2 could decrease the phage infection rate to 1.6% and 0.2% respectively in infected cells. For preventing phage infection in E. coli, the pGM2 decreased the phage infection rate to 0.1%, while pGM1 failed to block phage infection. Sequence verification revealed that point mutations in protospacer or protospacer adjacent motif sequences of the phage genome caused loss of the defense function. These results support the potential application of MCBAS in E. coli cell factories to defend against phage infections.

Keywords: phage infections     anti-phage     CRISPR-Cas9     conjugative transfer     synthetic biology    

Molecular mechanisms of leukemia-associated protein degradation

Ying-Li WU, Guo-Qiang CHEN, Hu-Chen ZHOU,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 363-370 doi: 10.1007/s11684-010-0210-7

Abstract: Chemical biology, using small molecules as probes to study the cellular signaling network, has developedThe interaction between chemistry and biology not only provides new insight into the understanding of

Keywords: protein degradation     leukemia     chemical biology     transcription factors     oncoprotein    

美国实验生物学会议(Experimental Biology Annual Meeting)

Conference Date: 6 Apr 2019

Conference Place: 美国/佛罗里达/奥兰多

Administered by: 美国实验生物学联合会(Federation of America Societies for Experimental Biology)

Next-Generation Imaging: New Insights from Multicolor Microscopy in Liver Biology and Disease

Felix Heymann, Adrien Guillot, Moritz Peiseler, Frank Tacke

Engineering 2022, Volume 9, Issue 2,   Pages 17-21 doi: 10.1016/j.eng.2021.06.015

Title Author Date Type Operation

Dendritic cell vaccines in cancer immunotherapy: from biology to translational medicine

Hongmei Xu, Xuetao Cao

Journal Article

Cytokine storm and translating IL-6 biology into effective treatments for COVID-19

Journal Article

Designer enzyme for green materials innovation: Lactate-polymerizing enzyme as a key catalyst

Seiichi Taguchi

Journal Article

MicroRNAs and lung cancers: from pathogenesis to clinical implications

Ji Qi, David Mu

Journal Article

Genome reprogramming for synthetic biology

Kylie Standage-Beier,Xiao Wang

Journal Article

Understanding channel tropism in traditional Chinese medicine in the context of systems biology

Ping Liu, Songlin Liu, Gang Chen, Ping Wang

Journal Article

Recent advances in fruit crop genomics

Qiang XU,Chaoyang LIU,Manosh Kumar BISWAS,Zhiyong PAN,Xiuxin DENG

Journal Article

To Hold the Economical Time of Biology,to Practicea Positive View of Happiness

Gan Ziheng

Journal Article

Systems understanding of plant–pathogen interactions through genome-wide protein–protein interaction networks

Hong LI,Ziding ZHANG

Journal Article

Associations between

Haican Liu, Yuanyuan Zhang, Zhiguang Liu, Jinghua Liu, Yolande Hauck, Jiao Liu, Haiyan Dong, Jie Liu, Xiuqin Zhao, Bing Lu, Yi Jiang, Gilles Vergnaud, Christine Pourcel, Kanglin Wan

Journal Article

Comparative lipidomic analysis of

Bin QIAO, Hong-Chi TIAN, Ying-Jin YUAN

Journal Article

Mobile CRISPR-Cas9 based anti-phage system in E. coli

Journal Article

Molecular mechanisms of leukemia-associated protein degradation

Ying-Li WU, Guo-Qiang CHEN, Hu-Chen ZHOU,

Journal Article

美国实验生物学会议(Experimental Biology Annual Meeting)

6 Apr 2019

Conference Information

Next-Generation Imaging: New Insights from Multicolor Microscopy in Liver Biology and Disease

Felix Heymann, Adrien Guillot, Moritz Peiseler, Frank Tacke

Journal Article