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biosensor 4

Biosensor 2

gold nanoparticles 2

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Biosensor-based assay of exosome biomarker for early diagnosis of cancer

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 157-175 doi: 10.1007/s11684-021-0884-z

Abstract: Cancer imposes a severe threat to people’s health and lives, thus pressing a huge medical and economic burden on individuals and communities. Therefore, early diagnosis of cancer is indispensable in the timely prevention and effective treatment for patients. Exosome has recently become an attractive cancer biomarker in noninvasive early diagnosis because of the unique physiology and pathology functions, which reflects remarkable information regarding the cancer microenvironment, and plays an important role in the occurrence and evolution of cancer. Meanwhile, biosensors have gained great attention for the detection of exosomes due to their superior properties, such as convenient operation, real-time readout, high sensitivity, and remarkable specificity, suggesting promising biomedical applications in the early diagnosis of cancer. In this review, the latest advances of biosensors regarding the assay of exosomes were summarized, and the superiorities of exosomes as markers for the early diagnosis of cancer were evaluated. Moreover, the recent challenges and further opportunities of developing effective biosensors for the early diagnosis of cancer were discussed.

Keywords： biosensor     exosome     cancer diagnosis    

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An antibiotic composite electrode for improving the sensitivity of electrochemically active biofilm biosensor

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 8, doi: 10.1007/s11783-022-1518-7

Abstract:

• Antibiotic azithromycin employed in graphite electrode for EAB biosensor

Keywords： AZM@GP composite electrode     EAB-biosensor     Water quality early-warning    

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Gold nanoparticles/single-stranded DNA-reduced graphene oxide nanocomposites based electrochemical biosensor

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 6,   Pages 1572-1582 doi: 10.1007/s11705-021-2112-4

Abstract: Moreover, the electrochemical biosensor showed good selectivity and acceptable accuracy for the detection

Keywords： reduced graphene oxide     gold nanoparticles     electrochemical biosensor     cholesterol oxidase     cholesterol    

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Effect of Ca

Qi WANG, Hongzhi JIANG, Shengli CHEN, Mingmin ZHANG, Mingxing DING, Esheng KONG, Guangying HUANG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 96-99 doi: 10.1007/s11684-009-0014-9

Abstract: The aim of this paper was to explore the relationship between energy metabolism and the meridian phenomenon. The manner of change of oxygen partial pressure in acupoints and no-acupoints of the urinary bladder meridian of goats was observed with a needle-type tissue oxygen tension sensor after the acupuncture effect was blocked by Ca complexation with ethylenediamine tetraacetic acid (EDTA)-Na . The results showed that: (1) the concentration of calcium ion in urinary bladder meridian acupoints was higher than that in no-acupoints ( <0.01 or <0.05); (2) the tissue oxygen tension in urinary bladder meridian acupoints was higher than that in no-acupoints ( <0.01); (3) the oxygen partial pressure in acupoints decreased significantly after injection with EDTA-Na , compared with injection of either normal sodium or nothing ( <0.01); (4) the oxygen partial pressure in acupoints was higher than that in no-acupoints after EDTA-Na injection ( <0.01). Acupuncture could reduce oxygen partial pressure in acupoints by regulating microcirculation and increasing metabolic levels.

Keywords： oxygen partial pressure     biosensor     calcium channels     acupoint    

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Anti-biofouling strategies for implantable biosensors of continuous glucose monitoring systems

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 12,   Pages 1866-1878 doi: 10.1007/s11705-023-2340-x

Abstract: In each strategy, the various biocompatible layers on the biosensor surface, such as drug-releasing membranes

Keywords： implantable glucose biosensor     anti-biofouling     continuous glucose monitoring     immune responses    

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Advances in airborne microorganisms detection using biosensors: A critical review

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 3, doi: 10.1007/s11783-021-1420-8

Abstract:

Humanity has been facing the threat of a variety of infectious diseases. Airborne microorganisms can cause airborne infectious diseases, which spread rapidly and extensively, causing huge losses to human society on a global scale. In recent years, the detection technology for airborne microorganisms has developed rapidly; it can be roughly divided into biochemical, immune, and molecular technologies.

Keywords： Biosensor     Airborne microorganisms     Microbiological detection technology    

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Genetic biosensors for small-molecule products: Design and applications in high-throughput screening

Qingzhuo Wang,Shuang-Yan Tang,Sheng Yang

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 1,   Pages 15-26 doi: 10.1007/s11705-017-1629-z

Abstract: Overproduction of small-molecule chemicals using engineered microbial cells has greatly reduced the production cost and promoted environmental protection. Notably, the rapid and sensitive evaluation of the concentrations of the desired products greatly facilitates the optimization process of cell factories. For this purpose, many genetic components have been adapted into biosensors of small molecules, which couple the intracellular concentrations of small molecules to easily detectable readouts such as fluorescence, absorbance, and cell growth. Such biosensors allow a high-throughput screening of the small-molecule products, and can be roughly classified as protein-based and RNA-based biosensors. This review summarizes the recent developments in the design and applications of biosensors for small-molecule products.

Keywords： biosensor     small molecule product     transcription factor     riboswitch     high-throughput screening    

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Rapid method for on-site determination of phenolic contaminants in water using a disposable biosensor

Yuanting LI, Dawei LI, Wei SONG, Meng LI, Jie ZOU, Yitao LONG

Frontiers of Environmental Science & Engineering 2012, Volume 6, Issue 6,   Pages 831-838 doi: 10.1007/s11783-012-0393-z

Abstract: A disposable biosensor was fabricated using single-walled carbon nanotubes, gold nanoparticles and tyrosinaseThe prepared biosensor was applied to the rapid determination of phenolic contaminants within 15 minutesAs an example, the biosensor for catechol determination displayed a linear range of 8.0 × 10 to 2.0Moreover, the resulting biosensor could be disposable, low-cost, reliable and easy to carry.This kind of new Tyr biosensor provides great potential for rapid, on-site and cost-effective analysis

Keywords： on-site determination     tyrosinase biosensor     phenolic contaminants     single-walled carbon nanotubes     gold    

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Shrink-induced graphene sensor for alpha-fetoprotein detection with low-cost self-assembly and label-free assay

Shota SANDO, Bo ZHANG, Tianhong CUI

Frontiers of Mechanical Engineering 2017, Volume 12, Issue 4,   Pages 574-580 doi: 10.1007/s11465-017-0485-3

Abstract:

Combination of shrink induced nano-composites technique and layer-by-layer (LbL) self-assembled graphene challenges controlling surface morphology. Adjusting shrink temperature achieves tunability on graphene surface morphology on shape memory polymers, and it promises to be an alternative in fields of high-surface-area conductors and molecular detection. In this study, self-assembled graphene on a shrink polymer substrate exhibits nanowrinkles after heating. Induced nanowrinkles on graphene with different shrink temperature shows distinct surface roughness and wettability. As a result, it becomes more hydrophilic with higher shrink temperatures. The tunable wettability promises to be utilized in, for example, microfluidic devices. The graphene on shrink polymer also exhibits capability of being used in sensing applications for pH and alpha-fetoprotein (AFP) detection with advantages of label free and low cost, due to self-assembly technique, easy functionalization, and antigen-antibody reaction on graphene surface. The detection limit of AFP detection is down to 1 pg/mL, and therefore the sensor also has a significant potential for biosensing as it relies on low-cost self-assembly and label-free assay.

Keywords： graphene     self-assembly     shrink polymer     AFP     label-free     biosensor    

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Microbial fuel cell with high content solid wastes as substrates: a review

Qingliang Zhao,Hang Yu,Weixian Zhang,Felix Tetteh Kabutey,Junqiu Jiang,Yunshu Zhang,Kun Wang,Jing Ding

Frontiers of Environmental Science & Engineering 2017, Volume 11, Issue 2, doi: 10.1007/s11783-017-0918-6

Abstract: Fundamentals and configuration design of MFCs fueled by HCSW were reviewed. HCSWs including sewage sludge, biomass and biowaste treated in MFCs were summarized. HCSW based MFCs technologies covered the types of sediment, soil, wetland and plant. Activated sludge process and composting could be coupled with HCSW-MFCs. HCSW-MFCs could be applied in bioremediation and biosensing. With the increasing concern about the serious global energy crisis and high energy consumption during high content solid wastes (HCSWs) treatment, microbial fuel cell (MFC) has been recognized as a promising resource utilization approach for HCSW stabilization with simultaneous electrical energy recovery. In contrast to the conventional HCSW stabilization processes, MFC has its unique advantages such as direct bio-energy conversion in a single step and mild reaction conditions (viz., ambient temperature, normal pressure, and neutral pH). This review mainly introduces some important aspects of electricity generation from HCSW and its stabilization in MFC, focusing on: (1) MFCs with different fundamentals and configurations designed and constructed to produce electricity from HCSW; (2) performance of wastes degradation and electricity generation; (3) prospect and deficiency posed by MFCs with HCSW as substrates. To date, the major drawback of MFCs fueled by HCSW is the lower power output than those using simple substrates. HCSW hydrolysis and decomposition would be a major tool to improve the performance of MFCs. The optimization of parameters is needed to push the progress of MFCs with HCSW as fuel.

Keywords： Microbial fuel cell     High content solid wastes     Substrate     Bioremediation     Biosensor    

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polyclonal antibody to the VP26 nucleocapsid protein of white spot syndrome virus (wssv) and its use as a biosensor

Suchera LOYPRASERT-THANANIMIT, Akrapon SALEEDANG, Proespichaya KANATHARANA, Panote THAVARUNGKUL, Wilaiwan CHOTIGEAT

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 2,   Pages 216-223 doi: 10.1007/s11705-012-1289-y

Abstract: The objective of this work was to produce a polyclonal antibody against VP26 and use it as a biosensorThe sensitivity of the biosensor was in the linear range of 160–160000 copies of WSSV, indicating thatThe specificity of the biosensor was supported by the observation that no impedance change was detectedThis biosensor may be applied to monitor the amount of WSSV in water during shrimp cultivation.

Keywords： recombinant protein     polyclonal antibody     label-free biosensor     impedance     white spot syndrome virus (WSSV    

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Title Author Date Type Operation

Biosensor-based assay of exosome biomarker for early diagnosis of cancer

Journal Article

An antibiotic composite electrode for improving the sensitivity of electrochemically active biofilm biosensor

Journal Article

Gold nanoparticles/single-stranded DNA-reduced graphene oxide nanocomposites based electrochemical biosensor

Journal Article

Effect of Ca

Qi WANG, Hongzhi JIANG, Shengli CHEN, Mingmin ZHANG, Mingxing DING, Esheng KONG, Guangying HUANG

Journal Article

Anti-biofouling strategies for implantable biosensors of continuous glucose monitoring systems

Journal Article

Advances in airborne microorganisms detection using biosensors: A critical review

Journal Article

Genetic biosensors for small-molecule products: Design and applications in high-throughput screening

Qingzhuo Wang,Shuang-Yan Tang,Sheng Yang

Journal Article

Rapid method for on-site determination of phenolic contaminants in water using a disposable biosensor

Yuanting LI, Dawei LI, Wei SONG, Meng LI, Jie ZOU, Yitao LONG

Journal Article

Shrink-induced graphene sensor for alpha-fetoprotein detection with low-cost self-assembly and label-free assay

Shota SANDO, Bo ZHANG, Tianhong CUI

Journal Article

Microbial fuel cell with high content solid wastes as substrates: a review

Qingliang Zhao,Hang Yu,Weixian Zhang,Felix Tetteh Kabutey,Junqiu Jiang,Yunshu Zhang,Kun Wang,Jing Ding

Journal Article

polyclonal antibody to the VP26 nucleocapsid protein of white spot syndrome virus (wssv) and its use as a biosensor

Suchera LOYPRASERT-THANANIMIT, Akrapon SALEEDANG, Proespichaya KANATHARANA, Panote THAVARUNGKUL, Wilaiwan CHOTIGEAT

Journal Article