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Celecoxib in combination with retinoid CD437 inhibits melanoma A375 cell

Jianwen REN, Zhenhui PENG, Birong GUO, Min PAN

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 108-112 doi: 10.1007/s11684-009-0015-8

Abstract: of celecoxib, synthetic retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic acid (CD437Both celecoxib and CD437 could inhibit the growth of human malignant melanoma A375 cells in a dose-dependentCelecoxib in combination with CD437 could significantly enhance the effects of inhibiting proliferationCD437 could inhibit the growth of human malignant melanoma A375 cells by inducing apoptosis and G /GCelecoxib exhibited additive effects with CD437 on retarding the growth and inducing apoptosis of human

Keywords： celecoxib     CD437     melanoma A375 cell     apoptosis     cycle arrest    

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Preclinical characterization and comparison between CD3/CD19 bispecific and novel CD3/CD19/CD20 trispecific

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 139-149 doi: 10.1007/s11684-021-0835-8

Abstract: The CD19-targeting bispecific T-cell engager blinatumomab has shown remarkable efficacy in patients withmultiple trials have shown that approximately 30% of blinatumomab-relapsed cases are characterized by CD19Blinatumomab and A-319 are CD3/CD19 bispecific antibodies with different molecular sizes and structures, and A-2019 is a novel CD3/CD19/CD20 trispecific antibody with an additional anti-CD20 function.in cells missing CD19, suggesting its potential function against CD19 weak or negative CD20 positive

Keywords： B-cell acute lymphoblastic leukemia     bispecific antibody     trispecific antibody     CD19     CD20    

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Clinical significance of CD34+CD117dim/CD34+CD117bri myeloblast-associated

Xueping Li, Yuting Dai, Bing Chen, Jinyan Huang, Saijuan Chen, Lu Jiang

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 608-620 doi: 10.1007/s11684-021-0836-7

Abstract: Two leukemic myeloblast populations (CD34 CD117 and CD34 CD117 ) were previously identified in t(8;21Here, we examined the impact of CD34 CD117 /CD34 CD117 myeloblast-associated gene expression on t(8;The mRNA expression levels of CD34 CD117 -associated genes ( , , and ) and CD34 CD117 -associated genesUnivariate analysis revealed that CD19, CD34 CD117 proportion, mutation, minimal residual diseaseIdentifying the clinical relevance of CD34 CD117 /CD34 CD117 myeloblast-associated gene expression may

Keywords： t(8     21)(q22     q22) AML     CD34+CD117dim/ CD34+CD117bri cell population    

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Comparisons in subcellular and biochemical behaviors of cadmium between low-Cd and high-Cd accumulation

Meng XUE, Yihui ZHOU, Zhongyi YANG, Biyun LIN, Jiangang YUAN, Shanshan WU

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 2,   Pages 226-238 doi: 10.1007/s11783-013-0582-4

Abstract: in low-Cd accumulation cultivars and high-Cd accumulation cultivars of pakchoi ( L.).low-Cd cultivars.The high-Cd cultivars had significantly higher leaf and stem Cd concentrations than the low-Cd cultivarsthan high-Cd cultivars, leaf vacuole sequestrated higher proportions of Cd.Cd in the form of pectate/protein complexes (extracted by 1 mol·L NaCl) played a decisive role in Cd

Keywords： cadmium (Cd)     low-Cd cultivar     pakchoi (Brassica chinensis L.)    

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Cultivars and oil extraction techniques affect Cd/Pb contents and health risks in oil of rapeseed grownon Cd/Pb-contaminated farmland

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 7, doi: 10.1007/s11783-023-1687-z

Abstract:

● Organic solvent extracted fewer Cd/Pb in rapeseed oil than physical

Keywords： Rapeseed oil     Oil extraction technologies     Human health risk assessment     Cd/Pb-contaminated farmland    

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Growth responses of the newly-discovered Cd-hyperaccumulator Rorippa globosa and its accumulation characteristicsof Cd and As under joint stress of Cd and As

SUN Yuebing, ZHOU Qixing, WEI Shuhe, REN Liping

Frontiers of Environmental Science & Engineering 2007, Volume 1, Issue 1,   Pages 107-113 doi: 10.1007/s11783-007-0020-6

Abstract: has been identified as a newly-found Cd-hyperaccumulating species.under joint stress of Cd and As.The results showed that Cd and As had an antagonistic effect on enhancing the growth of plants and Cdlevel under single Cd pollution.from a high concentration of Cd and As.

Keywords： synergic adverse     stress     present study     potential     weight    

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Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function ofCD19-specific CAR T-cells via TGF-β signaling

Frontiers of Medicine 2024, Volume 18, Issue 1,   Pages 128-146 doi: 10.1007/s11684-023-1010-1

Abstract: Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function ofCD19-specific CAR T-cells via TGF-β signaling

Keywords： exosomes induce activation     impair function CD19     exosomal CD19 antigen    

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Changes of phenotype and function of human CD4 CD25 T cells induced by transfection of Foxp3

WU Kui, BI Yutian, WANG Yaoli, WANG Changzheng

Frontiers of Medicine 2008, Volume 2, Issue 4,   Pages 366-369 doi: 10.1007/s11684-008-0070-6

Abstract: Virus-containing supernatant was applied to differentiate CD4CD25 T cells.The effect of transfected CD4 T cells on the proliferation and cytokine production of CD4CD25 T cellsexpressions of CD25 and CTLA-4, but down-regulated CD127 expression.Transfected T cells inhibited the proliferation of CD4CD25 T cells.This suggested a key role of Foxp3 in the generation of CD4CD25 regulatory T cells.
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Response of indigenous Cd-tolerant electrochemically active bacteria in MECs toward exotic Cr(VI) based

Xia Hou, Liping Huang, Peng Zhou, Hua Xue, Ning Li

Frontiers of Environmental Science & Engineering 2018, Volume 12, Issue 4, doi: 10.1007/s11783-018-1057-4

Abstract:

Cell membrane of indigenous Cd-tolerant EAB harbored more cadmium

Indigenous Cd-tolerant EAB cytoplasm located

Simultaneously quantitatively imaging Cd(II)

Keywords： Microbial electrolysis cell     Electrochemically active bacteria     Cd-tolerant bacteria     Cd(II) and Cr(VI)    

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Downregulation effects of beta-elemene on the levels of plasma endotoxin, serum TNF-alpha, and hepatic CD14

Jianguo LIU, Zhe ZHANG, Jiechang GAO, Jiwen XIE, Lin YANG, Shenjun HU

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 101-105 doi: 10.1007/s11684-011-0111-4

Abstract: CD14 expression in rat livers was measured by immunohistochemistry and Western blot.that β-elemene can downregulate the levels of plasma endotoxins, serum TNF-α, and hepatic CD14

Keywords： liver fibrosis     beta-elemene     endotoxin     CD14    

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CD47 blockade improves the therapeutic effect of osimertinib in non-small cell lung cancer

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 105-118 doi: 10.1007/s11684-022-0934-1

Abstract: In this study, OSI induced higher CD47 expression, an important anti-phagocytic immune checkpoint, viaThe combination treatment of OSI and the anti-CD47 antibody exhibited dramatically increasing phagocytosisConsistently, the enhanced phagocytosis index from combination treatment was reversed in CD47 knockoutMeanwhile, combining the anti-CD47 antibody significantly augmented the anticancer effect of OSI in HCC827antibody with OSI as a new strategy to enhance the anticancer efficacy in EGFR-mutant NSCLC with CD47

Keywords： osimertinib     anti-CD47 antibody     combination strategy     ADCP     EGFR    

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Moderate expression of CD39 in GPC3-CAR-T cells shows high efficacy against hepatocellular carcinoma

Frontiers of Medicine doi: 10.1007/s11684-024-1071-9

Abstract: CD39 serves as a crucial biomarker for neoantigen-specific CD8+ T cells and is associateddivision inhibitor-1 (mdivi-1), or knockdown CD39 through short hairpin RNA.antitumor activity, while high and low levels of CD39 led to an impaired cellular function.Methods modulating the proportion of CD39 intermediate (CD39int)-phenotype CAR-T cells suchas mdivi-1 and CD39 knockdown enhanced and impaired T cell function, respectively.

Keywords： CD39     CAR-T cells     mdivi-1     hepatocellular carcinoma     antitumor activity    

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Biological features of intrahepatic CD4+CD25+ T cells in the naturally tolerance of rat liver transplantation

LU Ling, ZHANG Feng, PU Liyong, YAO Aihua, YU Yue, SUN Beicheng, LI Guoqiang, WANG Xuehao

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 373-376 doi: 10.1007/s11684-007-0072-9

Abstract: The biological features of intrahepatic CD4CD25 T regulatory cells in the naturally tolerance of ratThe proportion of intrahepatic CD4CD25 T cells from three groups was determined by flow cytometry (FCMThe purity of CD4CD25 T cells sorted by MACS was 86%–93%.The CD4CD25 T cells could specifically express the Foxp3 gene compared with CD4CD25 T cells. , the spleenCD4CD25 Tr cells could suppress the proliferation of CD4CD25 T cells, but the inhibition was reversed

Keywords： magnetic     LEW-to-DA     effector     MACS     cytometry    

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Exosomal CD44 Cooperates with Integrin α6β4 to Support Organotropic Metastasis via Regulating Tumor Cell Article

Wei Mu, Yajie Xu, Pengfei Gu, Wenbo Wang, Jingquan Li, Yang Ge, Hui Wang

Engineering 2021, Volume 7, Issue 10,   Pages 1415-1425 doi: 10.1016/j.eng.2020.08.013

Abstract: For the first time, our study has demonstrated that CD44, a transmembrane glycoprotein delivered by exosomesMoreover, CD44 was found to interact with integrin α6β4 to form a complex, thereby remodelingNotably, we also demonstrated that the CD44–α6β4 complex can be delivered to the targetThe selective uptake of CD44-competent tumor exosomes by liver cells activated fibrotic pathways andOur results suggest the potential application of exosomal CD44 as a biomarker for the clinical diagnosis

Keywords： Pancreatic cancer     Organotropic metastasis     Exosomes     Pre-metastatic niche     CD44    

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Effects of organic acids on Cd adsorption and desorption by two anthropic soils

Jingui WANG, Jialong LV, Yaolong FU

Frontiers of Environmental Science & Engineering 2013, Volume 7, Issue 1,   Pages 19-30 doi: 10.1007/s11783-012-0424-9

Abstract: effects of malic, tartaric, oxalic, and citric acid on the adsorption and desorption characteristics of CdThe results showed that the Cd adsorption capacity of the lou soil was significantly greater than thatGenerally, Cd adsorption increased as the temperature increased.The endothermic reaction indicated that H bonds were the main driving force for Cd adsorption in bothThe adsorption percentage of Cd generally decreased as organic acid concentrations increased.

Keywords： adsorption     desorption     cadmium     organic acids     temperature     anthropic soil    

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Title Author Date Type Operation

Celecoxib in combination with retinoid CD437 inhibits melanoma A375 cell

Jianwen REN, Zhenhui PENG, Birong GUO, Min PAN

Journal Article

Preclinical characterization and comparison between CD3/CD19 bispecific and novel CD3/CD19/CD20 trispecific

Journal Article

Clinical significance of CD34+CD117dim/CD34+CD117bri myeloblast-associated

Xueping Li, Yuting Dai, Bing Chen, Jinyan Huang, Saijuan Chen, Lu Jiang

Journal Article

Comparisons in subcellular and biochemical behaviors of cadmium between low-Cd and high-Cd accumulation

Meng XUE, Yihui ZHOU, Zhongyi YANG, Biyun LIN, Jiangang YUAN, Shanshan WU

Journal Article

Cultivars and oil extraction techniques affect Cd/Pb contents and health risks in oil of rapeseed grownon Cd/Pb-contaminated farmland

Journal Article

Growth responses of the newly-discovered Cd-hyperaccumulator Rorippa globosa and its accumulation characteristicsof Cd and As under joint stress of Cd and As

SUN Yuebing, ZHOU Qixing, WEI Shuhe, REN Liping

Journal Article

Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function ofCD19-specific CAR T-cells via TGF-β signaling

Journal Article

Changes of phenotype and function of human CD4 CD25 T cells induced by transfection of Foxp3

WU Kui, BI Yutian, WANG Yaoli, WANG Changzheng

Journal Article

Response of indigenous Cd-tolerant electrochemically active bacteria in MECs toward exotic Cr(VI) based

Xia Hou, Liping Huang, Peng Zhou, Hua Xue, Ning Li

Journal Article

Downregulation effects of beta-elemene on the levels of plasma endotoxin, serum TNF-alpha, and hepatic CD14

Jianguo LIU, Zhe ZHANG, Jiechang GAO, Jiwen XIE, Lin YANG, Shenjun HU

Journal Article

CD47 blockade improves the therapeutic effect of osimertinib in non-small cell lung cancer

Journal Article

Moderate expression of CD39 in GPC3-CAR-T cells shows high efficacy against hepatocellular carcinoma

Journal Article

Biological features of intrahepatic CD4+CD25+ T cells in the naturally tolerance of rat liver transplantation

LU Ling, ZHANG Feng, PU Liyong, YAO Aihua, YU Yue, SUN Beicheng, LI Guoqiang, WANG Xuehao

Journal Article

Exosomal CD44 Cooperates with Integrin α6β4 to Support Organotropic Metastasis via Regulating Tumor Cell

Wei Mu, Yajie Xu, Pengfei Gu, Wenbo Wang, Jingquan Li, Yang Ge, Hui Wang

Journal Article

Effects of organic acids on Cd adsorption and desorption by two anthropic soils

Jingui WANG, Jialong LV, Yaolong FU

Journal Article