Resource Type

Journal Article 5

Year

2024 1

2020 2

2015 2

Keywords

Antibiotic adjuvant 1

Antibiotic resistance genes 1

Chelerythrine 1

Colistinmcr-1 1

Conjugation 1

Conjugation inhibitor 1

Dual effects 1

Molecular biological techniques 1

Nanofullerene 1

Sub-minimum inhibitory concentrations 1

acridine 1

antimicrobial activity 1

bio-conjugation 1

blue emitters 1

carbon nano-onions 1

conjugate 1

fluorescence 1

functional nanoprobes 1

isoquinolines 1

magnetic properties 1

open ︾

Search scope:

排序： Display mode:

Diversity-oriented synthesis of blue emissive nitrogen heterocycles and their conjugation with carbon

Viviana Maffeis, Lisa Moni, Daniele Di Stefano, Silvia Giordani, Renata Riva

Frontiers of Chemical Science and Engineering 2020, Volume 14, Issue 1,   Pages 76-89 doi: 10.1007/s11705-019-1833-0

Abstract: for new fluorescent molecules for possible applications as functional -electron systems and their conjugation

Keywords： carbon nano-onions     multicomponent reactions     blue emitters     fluorescence     isoquinolines    

HTML PDF Collect

SERS nanoprobes for bio-application

Han-Wen Cheng,Jin Luo,Chuan-Jian Zhong

Frontiers of Chemical Science and Engineering 2015, Volume 9, Issue 4,   Pages 428-441 doi: 10.1007/s11705-015-1536-0

Abstract: The ability to tune the size, shape, composition and surface properties impart nanoparticles with the desired functions for bio-application. This article highlights some of the recent examples in the exploration of metal (e.g., gold and silver) nanoparticles, especially those with magnetic properties and bio-conjugated structures, as theranostic nanoprobes. Such nanoprobes exhibit tunable optical, spectroscopic, magnetic, and electrical properties for signal amplifications. Examples discussed in this article will focus on the nanoproble-enhanced colorimetric detection and surface enhanced Raman scattering (SERS) detection of biomarkers or biomolecules such as proteins and DNAs. The understanding of factors controlling the biomolecular interactions is essential for the design of SERS nanoprobes with theranostic functions.

Keywords： surface-enhanced Raman scattering     functional nanoprobes     bio-conjugation     metal nanoparticles     magnetic    

HTML PDF Collect

Influences and mechanisms of nanofullerene on the horizontal transfer of plasmid-encoded antibiotic resistance genes between

Qingkun Ji, Caihong Zhang, Dan Li

Frontiers of Environmental Science & Engineering 2020, Volume 14, Issue 6, doi: 10.1007/s11783-020-1287-0

Abstract: employed to investigate the influences of nC60 at sub-minimum inhibitory concentrations (sub-MICs) on the conjugationCompared with the control group, nC60 significantly increased the conjugation rates of ARGs by 1.32‒10.82membrane proteins (OMPs) genes, increase membrane permeability, and thus promote the occurrence of conjugation

Keywords： Nanofullerene     Sub-minimum inhibitory concentrations     Antibiotic resistance genes     Conjugation     Molecular    

HTML PDF Collect

Conjugation with Acridines Turns Nuclear Localization Sequence into Highly Active Antimicrobial Peptide Artical

Wei Zhang,Xiaoli Yang,Jingjing Song,Xin Zheng,Jianbo Chen,Panpan Ma,Bangzhi Zhang,Rui Wang

Engineering 2015, Volume 1, Issue 4,   Pages 500-505 doi: 10.15302/J-ENG-2015106

Abstract:

The emergence of multidrug-resistant bacteria creates an urgent need for alternative antibiotics with new mechanisms of action. In this study, we synthesized a novel type of antimicrobial agent, Acr3-NLS, by conjugating hydrophobic acridines to the N-terminus of a nuclear localization sequence (NLS), a short cationic peptide. To further improve the antimicrobial activity of our agent, dimeric (Acr3-NLS)2 was simultaneously synthesized by joining two monomeric Acr3-NLS together via a disulfide linker. Our results show that Acr3-NLS and especially (Acr3-NLS)2 display significant antimicrobial activity against gram-negative and gram-positive bacteria compared to that of the NLS. Subsequently, the results derived from the study on the mechanism of action demonstrate that Acr3-NLS and (Acr3-NLS)2 can kill bacteria by membrane disruption and DNA binding. The double targets–cell membrane and intracellular DNA–will reduce the risk of bacteria developing resistance to Acr3-NLS and (Acr3-NLS)2. Overall, this study provides a novel strategy to design highly effective antimicrobial agents with a dual mode of action for infection treatment.

Keywords： acridine     nuclear localization sequence     conjugate     antimicrobial activity     mechanism of action    

HTML PDF Collect

Dual Effects of Feed-Additive-Derived Chelerythrine in Combating Mobile Colistin Resistance Article

Huangwei Song,Xueyang Wang,Muchen Zhang,Zhiyu Zou,Siyuan Yang,Tian Yi,Jianfeng Wang,Dejun Liu,Yingbo Shen,Chongshan Dai,Zhihai Liu,Timothy R. Walsh,Jianzhong Shen,Congming Wu,Yang Wang,

Engineering 2024, Volume 32, Issue 1,   Pages 163-173 doi: 10.1016/j.eng.2023.06.012

Abstract: CFUs) of an mcr-1-carrying strain in a murine intestinal infection model, and inhibited the conjugationintracellular adenosine triphosphate (ATP) levels, which subsequently downregulates mcr-1 and conjugation-associated

Keywords： Chelerythrine     Antibiotic adjuvant     Conjugation inhibitor     Colistinmcr-1     Dual effects    

HTML PDF Collect

Title Author Date Type Operation

Diversity-oriented synthesis of blue emissive nitrogen heterocycles and their conjugation with carbon

Viviana Maffeis, Lisa Moni, Daniele Di Stefano, Silvia Giordani, Renata Riva

Journal Article

SERS nanoprobes for bio-application

Han-Wen Cheng,Jin Luo,Chuan-Jian Zhong

Journal Article

Influences and mechanisms of nanofullerene on the horizontal transfer of plasmid-encoded antibiotic resistance genes between

Qingkun Ji, Caihong Zhang, Dan Li

Journal Article

Conjugation with Acridines Turns Nuclear Localization Sequence into Highly Active Antimicrobial Peptide

Wei Zhang,Xiaoli Yang,Jingjing Song,Xin Zheng,Jianbo Chen,Panpan Ma,Bangzhi Zhang,Rui Wang

Journal Article

Dual Effects of Feed-Additive-Derived Chelerythrine in Combating Mobile Colistin Resistance

Huangwei Song,Xueyang Wang,Muchen Zhang,Zhiyu Zou,Siyuan Yang,Tian Yi,Jianfeng Wang,Dejun Liu,Yingbo Shen,Chongshan Dai,Zhihai Liu,Timothy R. Walsh,Jianzhong Shen,Congming Wu,Yang Wang,

Journal Article