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A Novel Human Antibody, HF, against HER2/erb-B2 Obtained by a Computer-Aided Antibody Design Method Article

Chunxia Qiao, Ming Lv, Xinying Li, Xiaoling Lang, Shouqin Lv, Mian Long, Yan Li, Shusheng Geng, Zhou Lin, Beifen Shen , Jiannan Feng

Engineering 2021, Volume 7, Issue 11,   Pages 1566-1576 doi: 10.1016/j.eng.2020.10.024

Abstract: display method (in vitro) or by transgenic mice (in vivo); other methods include BBased on the complex structure of human epidermal growth factor receptor 2 (HER2)/Herceptin, we firstdesigned six short peptides targeting the potential epitope of HER2 recognized by Herceptin.complementarity determining regions in a suitable immunoglobulin frame, giving birth to a novel anti-HER2

Keywords： HER2/erb-B2     Human antibody     Computer-aided design    

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resistance to endocrine therapy in hormone receptor-positive human epidermal growth factor receptor 2-

Wenjie Zhu, Binghe Xu

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 208-220 doi: 10.1007/s11684-020-0795-4

Abstract: have been developed to overcome resistance to endocrine therapy (ET) and improve the outcome of HR /HER2on randomized controlled trials evaluating various targeted therapies in combination with ET in HR /HER2

Keywords： endocrine-resistant     HR+/HER2- advanced breast cancer     randomized clinical trials    

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Fenton oxidation of 2,4- and 2,6-dinitrotoluene and acetone inhibition

HE Yiliang, ZHAO Bin, HUGHES Joseph B., HAN Sung Soo

Frontiers of Environmental Science & Engineering 2008, Volume 2, Issue 3,   Pages 326-332 doi: 10.1007/s11783-008-0038-4

Abstract: The performances and kinetic parameters of Fenton oxidation of 2,4- and 2,6-dinitrotoluene (DNT) in water-acetone- and 2,6-DNT.- and 2,6-DNT completely, mainly due to the competition of hydroxyl radicals.Fenton oxidation of 2,4- and 2,6-DNT fit well with the first-order kinetics and the presence of acetone-DNT primary degradation was proposed: 2,4-DNT → 2,4-dinitro-benzaldehyde → 2,4-dinitrobenzoic acid →

Keywords： presence     2     4-DNT     competition     laboratory     scavenger    

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Detection of maternal serum thromboxane B2 in different durations of pregnancy and prediction of preeclampsia

Geqing XIA MD, Zehua WANG MD, Li ZOU MD, Chaoying WU MS, Yu HU MD,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 235-240 doi: 10.1007/s11684-010-0002-0

Abstract: This study was aimed to detect maternal serum levels of thromboxane B2 (TXB2) in different durationsof pregnancy and explore the predictive value of TXB2 for preeclampsia.Maternal serum levels of TXB2 were measured by enzyme-linked immunoassay.of pregnancy, the levels of maternal serum TXB2 in the 180 cases gradually ascended as seen throughHigher levels of maternal serum TXB2 were detected a long time before clinical symptoms appeared.

Keywords： thromboxane B2     preeclampsia    

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Anti-β glycoprotein I antibodies in complex with β2 glycoprotein I induce platelet activation via tworeceptors: apolipoprotein E receptor 2' and glycoprotein I bα

Wenjing Zhang,Fei Gao,Donghe Lu,Na Sun,Xiaoxue Yin,Meili Jin,Yanhong Liu

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 76-84 doi: 10.1007/s11684-015-0426-7

Abstract: ba (GP I bα) in platelet activation induced by the anti-β2GP I /β2b/ III a activation and P-selectin expression andthromboxane B2 production as well as p38 mitogen-activated protein kinase phosphorylationactivate platelets, and this activation was inhibited by either the anti-GP I bα antibody or theactivation via GP I bα and apoER2', which may then contribute to the prothrombotic tendency

Keywords： anti-β2GP I /β2GP I complex     platelet     GP I bα     apoER2'     thrombosis    

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>In situ growth of phosphorized ZIF-67-derived amorphous CoP/Cu2O@CF electrocatalyst

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 10,   Pages 1430-1439 doi: 10.1007/s11705-023-2320-1

Abstract: self-supporting copper foam (CF) substrate with excellent performance for hydrogen evolution reaction (HERThe intermediate product was phosphorized to obtain final electrocatalyst (CoP/Cu2O@CF) withThe electrochemical measurement proved that CoP/Cu2O@CF catalyst exhibited excellent HER activitywas only 62 mV with the Tafel slope of 83 mV·dec–1 at a current density of 10 mA·cm–2HER activity of CoP/Cu2O@CF catalyst, which will act as

Keywords： CoP/Cu2O@CF     electrocatalyst     phosphorization     HER     DFT    

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Study of recombinant human IFN-α-2b bacilli Calmette–Guerin activated killer cells and against bladder

FAN Xiaodong, HAN Ruifa

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 377-380 doi: 10.1007/s11684-007-0073-8

Abstract: Recombinant IFN--2b-BCG, wild-type BCG (wBCG), wild-type BCG and IFN--2b were coincubated with PBMCs

Keywords： Urology     powerful     2b-BCG     Tianjin institute     wild-type    

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Neutralization against SARS-CoV-2 Delta/Omicron variants and B cell response after inactivated vaccination

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 747-757 doi: 10.1007/s11684-022-0954-x

Abstract: Emerging SARS-CoV-2 variants have made COVID-19 convalescents susceptible to re-infection and have raisedefficacy of inactivated vaccination in neutralization against emerging variants and antigen-specific B, and 18.5 (Visit 3) months after SARS-CoV-2 infection.Similarly, the responses of SARS-CoV-2 RBD-specific B cells and memory B cells were boosted by the secondvariants and memory B cell responses.

Keywords： COVID-19 convalescent     SARS-CoV-2     inactivated vaccination     neutralizing antibody     B cell response    

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A small-molecule pan-HER inhibitor alone or in combination with cisplatin exerts efficacy against nasopharyngeal

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 275-289 doi: 10.1007/s11684-022-0945-y

Abstract: explored the anti-tumor effects of the novel pan-HER inhibitor HM781-36B, alone or in combination withHM781-36B inhibited NPC in vitro and in vivo.In NPC xenograft models in nude mice, HM781-36B and cisplatin synergistically inhibited tumor growth.tumor microenvironment may explain the synergistic anti-tumor effects of HM781-36B and cisplatin.The pan-HER inhibitor HM781-36B alone or in combination with cisplatin represents promising therapeutic

Keywords： epidermal growth factor receptor     ErbB receptors     HM781-36B     nasopharyngeal carcinoma     molecular targeted    

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Inhibition of protein kinase B by Palmitate in the insulin signaling of HepG2 cells and the preventive

XIA Yanzhi, WAN Xuedong, DUAN Qiuhong, HE Shansu, WANG Ximing

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 200-206 doi: 10.1007/s11684-007-0038-y

Abstract: of free fatty acids (FFAs) may contribute to insulin resistance (IR) that is characteristic of type 2

Keywords： palmitate     characteristic     study     plasma     resistance    

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Prognostic value of the 21-gene recurrence score in ER-positive, HER2-negative, node-positive breast

Jiayi Wu, Weiqi Gao, Xiaosong Chen, Chunxiao Fei, Lin Lin, Weiguo Chen, Ou Huang, Siji Zhu, Jianrong He, Yafen Li, Li Zhu, Kunwei Shen

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 621-628 doi: 10.1007/s11684-020-0738-0

Abstract: Chinese patients with pN0-1, estrogen receptor-positive (ER ), human epidermal growth factor receptor 2-negative (HER2 ) breast cancer.Our findings suggested that RS may predict IDFS in Chinese patients with ER /HER2 breast cancer with

Keywords： early breast cancer     21-gene assay     recurrence score     prognosis    

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第三届环境、工业和能源工程国际会议(EI2E 2019)

Conference Date: 19 Sep 2019

Conference Place: 宁夏银川

Administered by: APISE

Aldolase B attenuates clear cell renal cell carcinoma progression by inhibiting CtBP2

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 503-517 doi: 10.1007/s11684-022-0947-9

Abstract: Aldolase B (ALDOB), a glycolytic enzyme, is uniformly depleted in clear cell renal cell carcinoma (ccRCCWe showed that the corepressor C-terminal-binding protein 2 (CtBP2) is a novel ALDOB-interacting proteinThe CtBP2-to-ALDOB expression ratio in clinical samples was correlated with the expression of CtBP2 targetALDOB inhibited CtBP2-mediated repression of multiple cell cycle inhibitor, proapoptotic, and epithelial4-methylthio 2-oxobutyric acid.

Keywords： ALDOB     kidney cancer     cell proliferation    

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Challenge of global climate change: Prospects for a new energy paradigm

Michael B. MCELROY

Frontiers of Environmental Science & Engineering 2010, Volume 4, Issue 1,   Pages 2-11 doi: 10.1007/s11783-010-0005-8

Abstract: Perspectives on the challenge posed by potential future climate change are presented including a discussion of prospects for carbon capture followed either by sequestration or reuse including opportunities for alternatives to the use of oil in the transportation sector. The potential for wind energy as an alternative to fossil fuel energy as a source of electricity is outlined including the related opportunities for cost effective curtailment of future growth in emissions of CO.

Keywords： climate change     carbon capture     wind     ethanol     CO2     radiative forcing    

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Hyperbranched azo polyurethane synthesized through A + B scheme

CHE Pengchao, HE Yaning, WANG Xiaogong

Frontiers of Chemical Science and Engineering 2008, Volume 2, Issue 1,   Pages 123-126 doi: 10.1007/s11705-007-0078-5

Abstract: synthesized by one-step polymerization of an A type monomer diphenylmethane-4,4′-diisocyanate and a Btype monomer 4-(N,N′-bis(2-hydroxyethyl))amino-2′-hydroxyethoxyl-4′-nitro-azobenzene.

Keywords： dimethylformamide     one-step polymerization     polyurethane     2-hydroxyethyl     diphenylmethane-4     4′-diisocyanate    

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Title Author Date Type Operation

A Novel Human Antibody, HF, against HER2/erb-B2 Obtained by a Computer-Aided Antibody Design Method

Chunxia Qiao, Ming Lv, Xinying Li, Xiaoling Lang, Shouqin Lv, Mian Long, Yan Li, Shusheng Geng, Zhou Lin, Beifen Shen , Jiannan Feng

Journal Article

resistance to endocrine therapy in hormone receptor-positive human epidermal growth factor receptor 2-

Wenjie Zhu, Binghe Xu

Journal Article

Fenton oxidation of 2,4- and 2,6-dinitrotoluene and acetone inhibition

HE Yiliang, ZHAO Bin, HUGHES Joseph B., HAN Sung Soo

Journal Article

Detection of maternal serum thromboxane B2 in different durations of pregnancy and prediction of preeclampsia

Geqing XIA MD, Zehua WANG MD, Li ZOU MD, Chaoying WU MS, Yu HU MD,

Journal Article

Anti-β glycoprotein I antibodies in complex with β2 glycoprotein I induce platelet activation via tworeceptors: apolipoprotein E receptor 2' and glycoprotein I bα

Wenjing Zhang,Fei Gao,Donghe Lu,Na Sun,Xiaoxue Yin,Meili Jin,Yanhong Liu

Journal Article

>In situ growth of phosphorized ZIF-67-derived amorphous CoP/Cu2O@CF electrocatalyst

Journal Article

Study of recombinant human IFN-α-2b bacilli Calmette–Guerin activated killer cells and against bladder

FAN Xiaodong, HAN Ruifa

Journal Article

Neutralization against SARS-CoV-2 Delta/Omicron variants and B cell response after inactivated vaccination

Journal Article

A small-molecule pan-HER inhibitor alone or in combination with cisplatin exerts efficacy against nasopharyngeal

Journal Article

Inhibition of protein kinase B by Palmitate in the insulin signaling of HepG2 cells and the preventive

XIA Yanzhi, WAN Xuedong, DUAN Qiuhong, HE Shansu, WANG Ximing

Journal Article

Prognostic value of the 21-gene recurrence score in ER-positive, HER2-negative, node-positive breast

Jiayi Wu, Weiqi Gao, Xiaosong Chen, Chunxiao Fei, Lin Lin, Weiguo Chen, Ou Huang, Siji Zhu, Jianrong He, Yafen Li, Li Zhu, Kunwei Shen

Journal Article

第三届环境、工业和能源工程国际会议(EI2E 2019)

19 Sep 2019

Conference Information

Aldolase B attenuates clear cell renal cell carcinoma progression by inhibiting CtBP2

Journal Article

Challenge of global climate change: Prospects for a new energy paradigm

Michael B. MCELROY

Journal Article

Hyperbranched azo polyurethane synthesized through A + B scheme

CHE Pengchao, HE Yaning, WANG Xiaogong

Journal Article