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Paradoxical role of Id proteins in regulating tumorigenic potential of lymphoid cells

Sumedha Roy, Yuan Zhuang

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 374-386 doi: 10.1007/s11684-018-0652-x

Abstract:

A family of transcription factors known as Id proteins, or inhibitor of DNA binding and differentiationDue to their ability to promote self-renewal, Id proteins have been considered as oncogenes, and potentialThe contexts and mechanisms by which Id proteins can serve in such contradictory roles to determine tumorTranscriptional regulation by E proteins, and their antagonism by Id proteins, act as gatekeepers toThese mechanistic insights can allow better appreciation of the context-dependent roles of Id proteins

Keywords： Id proteins     lymphoma     leukemia     T cells     B cells     tumor suppressor     oncogene    

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Novel engineered proteins for mechanomaterials

Giuseppe Portale

Frontiers of Chemical Science and Engineering 2020, Volume 14, Issue 6,   Pages 1122-1123 doi: 10.1007/s11705-020-1941-x

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Caveolin proteins: a molecular insight into disease

Hongli Yin,Tianyi Liu,Ying Zhang,Baofeng Yang

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 397-404 doi: 10.1007/s11684-016-0483-6

Abstract: This article focuses on the relationship between caveolin proteins and human diseases and reviews the

Keywords： caveolin     caveolae     microRNA     disease     signaling pathway     heart     tumor    

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Changes in structure and functional properties of whey proteins induced by high hydrostatic pressure:

Xiaoming LIU, Jia NING, Stephanie CLARK,

Frontiers of Chemical Science and Engineering 2009, Volume 3, Issue 4,   Pages 436-442 doi: 10.1007/s11705-009-0251-0

Abstract: the research conducted to understand the effect of HHP on structure and functional properties of whey proteins

Keywords： -lactoglobulin     processing     functional     alternative technology     environmental    

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Cross-sectional network analysis of plasma proteins/metabolites correlated with pathogenesis and therapeutic

Frontiers of Medicine 2024, Volume 18, Issue 2,   Pages 327-343 doi: 10.1007/s11684-023-1022-x

Abstract: heightened proliferation and energy consumption in APL blasts, and the other featured APL plasma-enriched proteinsfrom therapy-induced cell death or senescence and ensuing supraphysiological levels of intracellular proteins

Keywords： acute promyelocytic leukemia     plasma proteomics     plasma metabolomics     cross-sectional correlation network     pathogenesis     treatment    

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Proteome comparisons reveal influence of different dietary proteins on the development of rat jejunum

Mengjie LI, Chunbao LI, Shangxin SONG, Xinglian XU, Guanghong ZHOU

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 3,   Pages 362-372 doi: 10.15302/J-FASE-2018206

Abstract: compared proteome profiles and morphological changes of rat jejunum in response to different dietary proteinsmale Sprague-Dawley rats were fed with casein (control), and isolated beef, pork, fish and chicken proteinsThe results indicated that rats fed with chicken proteins had higher PEPT1 mRNA and protein levels (proteins had no significant effect on PEPT1 expression, they altered

Keywords： Hippo signaling pathway     meat protein     PEPT1     proteome analysis     rat jejunum    

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Identification of transporter proteins for PQQ-secretion pathways by transcriptomics and proteomics analysis

Hui Wan,Yu Xia,Jianghua Li,Zhen Kang,Jingwen Zhou

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 1,   Pages 72-88 doi: 10.1007/s11705-016-1580-4

Abstract: We have identified 73 differentially expressed proteins and 99 differentially expressed genes, a majorityThe results suggest that the proteins encoded by PqqB, B932_1930 and B932_2186 might enhance the PQQ

Keywords： 2D-DIGE     pqqB     pyrroloquinoline quinone     RNA-Seq     Vitamin C    

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Fate of proteins of waste activated sludge during thermal alkali pretreatment in terms of sludge protein

Xiaoli Song, Zhenghua Shi, Xiufen Li, Xinhua Wang, Yueping Ren

Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 2, doi: 10.1007/s11783-019-1114-7

Abstract: itemcontent>

Over 90 min of TAH at the optimal condition, 67.59% sludge proteins

15.84% soluble proteins broke down to materials

Keywords： Sludge flocs     Microbial cells     Hydrolysate     Protein breakdown     Melanoidin    

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reduces IgE binding ability of allergenic egg white proteins

Sen LI, Marina OFFENGENDEN, Michael G. GÄNZLE, Jianping WU

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 3,   Pages 373-381 doi: 10.15302/J-FASE-2018210

Abstract:

Egg white proteins are one of the major allergens.investigate the effect of Aspergillus oryzae cultivation on IgE binding ability of egg white proteinsEffect of A. oryzae on egg white proteins was determined using ninhydrin method, SDS-PAGE, ELISAThe binding capacity of egg white proteins to IgE in plasma from four egg allergy patients was almostTherefore, the reduction of IgE binding ability of egg white proteins during A. oryzae treatment

Keywords： Aspergillus oryzae     egg allergy     egg white proteins     IgE-binding ability     ovomucoid    

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iTRAQ-based quantitative proteomic analysis on differentially expressed proteins of rat mandibular condylar

Liting Jiang,Yinyin Xie,Li Wei,Qi Zhou,Ning Li,Xinquan Jiang,Yiming Gao

Frontiers of Medicine 2017, Volume 11, Issue 1,   Pages 97-109 doi: 10.1007/s11684-016-0496-1

Abstract: signaling in vivo, we evaluated the structural changes of MCC and differentially expressed proteinsA total of 805 differentially expressed proteins were then identified.GO analysis revealed a significant number of proteins involved in the metabolic process, cellular processKEGG pathway analysis also suggested that these proteins participated in various signaling pathways,

Keywords： condylar cartilage     mechanical loading     proteomic analysis     iTRAQ     bioinformatics analysis    

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Proteins moonlighting in tumor metabolism and epigenetics

Lei Lv, Qunying Lei

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 383-403 doi: 10.1007/s11684-020-0818-1

Abstract: Cancer development is a complicated process controlled by the interplay of multiple signaling pathways and restrained by oxygen and nutrient accessibility in the tumor microenvironment. High plasticity in using diverse nutrients to adapt to metabolic stress is one of the hallmarks of cancer cells. To respond to nutrient stress and to meet the requirements for rapid cell proliferation, cancer cells reprogram metabolic pathways to take up more glucose and coordinate the production of energy and intermediates for biosynthesis. Such actions involve gene expression and activity regulation by the moonlighting function of oncoproteins and metabolic enzymes. The signal−moonlighting protein−metabolism axis facilitates the adaptation of tumor cells under varying environment conditions and can be therapeutically targeted for cancer treatment.

Keywords： moonlighting function     tumor metabolism     epigenetics    

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Expression status of GATA3 and mismatch repair proteins in upper tract urothelial carcinoma

Yue Wang, Jinxia Zhang, Yunfan Wang, Shufang Wang, Yu Zhang, Qi Miao, Fei Gao, Huiying He

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 730-740 doi: 10.1007/s11684-019-0687-7

Abstract: Here, we immunohistochemically stained GATA3 and MMR proteins in 108 UTUC samples.The absence of MMR proteins was observed in 8.3% of the cases, and focal staining was identified in 13.0%

Keywords： upper tract urothelial carcinoma     GATA binding protein 3     mismatch repair     microsatellite instability     prognosis    

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Anaerobic digestion of sludge by different pretreatments: Changes of amino acids and microbial community

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 2, doi: 10.1007/s11783-021-1458-7

Abstract: List>

•Tryptophan protein, and aromatic protein I/II were the key identified proteins

Keywords： Sludge pretreatments     Dissolved organic nitrogen     Proteins     Amino acids     Structural equation model     Metagenomic    

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Transformer2 proteins protect breast cancer cells from accumulating replication stress by ensuring productive

Andrew Best,Katherine James,Gerald Hysenaj,Alison Tyson-Capper,David J. Elliott

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 2,   Pages 186-195 doi: 10.1007/s11705-015-1540-4

Abstract: cross-regulation between Tra2 and the highly similar Tra2 protein in human breast cancer cells, though these two proteinsDiscovery of this cross-regulation pathway, and its by-pass by joint depletion of both human Tra2 proteins, revealed Tra2 proteins are essential for breast cancer cell viability, and led to the identificationBreast cancer cells depleted for Tra2 proteins have reduced CHK1 protein levels and accumulate DNA damageThese data suggest Tra2 proteins and/or their splicing targets as possible cancer drug targets.

Keywords： RNA splicing     gene expression     breast cancer     DNA damage     CHK1    

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Comparative proteomic analysis of cold responsive proteins in two wheat cultivars with different tolerance

Shujuan ZHANG,Guoqi SONG,Yulian LI,Jie GAO,Jiao WANG,Guiju CHEN,Haosheng LI,Genying LI,Zhendong ZHAO

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 1,   Pages 37-45 doi: 10.15302/J-FASE-2014008

Abstract: responding to SRF, a comparative proteomic analysis was performed to analyze the changes of the key proteinsA total of 43 differentially expressed proteins (DEPs) which mainly involved in carbohydrate metabolism, amino acid metabolism, resistance proteins and antioxidant enzymes, photosynthesis and cellular respirationproteins, cell-wall related proteins, protein translation/processing/degradation and signal transduction

Keywords： common wheat     spring radiation frost     proteomic analysis     2-DE     MALDI-TOF-TOF MS    

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Title Author Date Type Operation

Paradoxical role of Id proteins in regulating tumorigenic potential of lymphoid cells

Sumedha Roy, Yuan Zhuang

Journal Article

Novel engineered proteins for mechanomaterials

Giuseppe Portale

Journal Article

Caveolin proteins: a molecular insight into disease

Hongli Yin,Tianyi Liu,Ying Zhang,Baofeng Yang

Journal Article

Changes in structure and functional properties of whey proteins induced by high hydrostatic pressure:

Xiaoming LIU, Jia NING, Stephanie CLARK,

Journal Article

Cross-sectional network analysis of plasma proteins/metabolites correlated with pathogenesis and therapeutic

Journal Article

Proteome comparisons reveal influence of different dietary proteins on the development of rat jejunum

Mengjie LI, Chunbao LI, Shangxin SONG, Xinglian XU, Guanghong ZHOU

Journal Article

Identification of transporter proteins for PQQ-secretion pathways by transcriptomics and proteomics analysis

Hui Wan,Yu Xia,Jianghua Li,Zhen Kang,Jingwen Zhou

Journal Article

Fate of proteins of waste activated sludge during thermal alkali pretreatment in terms of sludge protein

Xiaoli Song, Zhenghua Shi, Xiufen Li, Xinhua Wang, Yueping Ren

Journal Article

reduces IgE binding ability of allergenic egg white proteins

Sen LI, Marina OFFENGENDEN, Michael G. GÄNZLE, Jianping WU

Journal Article

iTRAQ-based quantitative proteomic analysis on differentially expressed proteins of rat mandibular condylar

Liting Jiang,Yinyin Xie,Li Wei,Qi Zhou,Ning Li,Xinquan Jiang,Yiming Gao

Journal Article

Proteins moonlighting in tumor metabolism and epigenetics

Lei Lv, Qunying Lei

Journal Article

Expression status of GATA3 and mismatch repair proteins in upper tract urothelial carcinoma

Yue Wang, Jinxia Zhang, Yunfan Wang, Shufang Wang, Yu Zhang, Qi Miao, Fei Gao, Huiying He

Journal Article

Anaerobic digestion of sludge by different pretreatments: Changes of amino acids and microbial community

Journal Article

Transformer2 proteins protect breast cancer cells from accumulating replication stress by ensuring productive

Andrew Best,Katherine James,Gerald Hysenaj,Alison Tyson-Capper,David J. Elliott

Journal Article

Comparative proteomic analysis of cold responsive proteins in two wheat cultivars with different tolerance

Shujuan ZHANG,Guoqi SONG,Yulian LI,Jie GAO,Jiao WANG,Guiju CHEN,Haosheng LI,Genying LI,Zhendong ZHAO

Journal Article