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Application of StrucGP in medical immunology: site-specific -glycoproteomic analysis of macrophages

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 304-316 doi: 10.1007/s11684-022-0964-8

Abstract: The structure of N-glycans on specific proteins can regulate innate and adaptive immunity via sensing environmental signals. Meanwhile, the structural diversity of N-glycans poses analytical challenges that limit the exploration of specific glycosylation functions. In this work, we used THP-1-derived macrophages as examples to show the vast potential of a N-glycan structural interpretation tool StrucGP in N-glycoproteomic analysis. The intact glycopeptides of macrophages were enriched and analyzed using mass spectrometry (MS)-based glycoproteomic approaches, followed by the large-scale mapping of site-specific glycan structures via StrucGP. Results revealed that bisected GlcNAc, core fucosylated, and sialylated glycans (e.g., HexNAc4Hex5Fuc1Neu5Ac1, N4H5F1S1) were increased in M1 and M2 macrophages, especially in the latter. The findings indicated that these structures may be closely related to macrophage polarization. In addition, a high level of glycosylated PD-L1 was observed in M1 macrophages, and the LacNAc moiety was detected at Asn-192 and Asn-200 of PD-L1, and Asn-200 contained Lewis epitopes. The precision structural interpretation of site-specific glycans and subsequent intervention of target glycoproteins and related glycosyltransferases are of great value for the development of new diagnostic and therapeutic approaches for different diseases.

Keywords: macrophage     glycoproteome     glycopeptides     N-glycan structures     PD-L1    

Achievements in burn surgery over the past 50 years in China

WANG Shiliang

Frontiers of Medicine 2008, Volume 2, Issue 4,   Pages 332-336 doi: 10.1007/s11684-008-0063-5

Abstract: wound repair and rehabilitation, and special types of burns; it also covers pathology, microbiology, immunology

Keywords: immunology     scientific     nutritional     microbiology     engineering    

Mechanism of arterial remodeling in chronic allograft vasculopathy

Qichang Zheng, Shanglong Liu, Zifang Song

Frontiers of Medicine 2011, Volume 5, Issue 3,   Pages 248-253 doi: 10.1007/s11684-011-0149-3

Abstract: Chronic allograft vasculopathy (CAV) remains a major obstacle for long-term survival of grafts even though therapeutic strategies have improved considerably in recent years. CAV is characterized by concentric and diffuse neointimal formation, medial apoptosis, infiltration of lymphocyte or inflammatory cells, and deposition of extracellular matrix both in arteries and veins. Recent studies have shown that stem cells derived from the recipient contribute to neointimal formation under the regulation of chemokines and cytokines. Arterial remodeling in allografts eventually causes ischemic graft failure. The pathogenesis is multi-factorial with both immunologic and non-immunological factors being involved. The immunological factors have been discussed extensively in other articles. This review focuses mainly on the arterial remodeling that occurs in 3 layers of vessel walls including intimal injury, accumulation of smooth muscle-like cells in the neointimal, medial smooth muscle cell apoptosis, adventitial fibrosis, and deposition of extracellular matrix.

Keywords: transplantation     chronic rejection     neointimal     immunology     arterial remodeling     allograft vasculopathy    

Role of Intrahepatic Regional Immunity in Post-Transplant Cancer Recurrence Review

Jiang Liu,Chung Mau Lo,Kwan Man

Engineering 2022, Volume 10, Issue 3,   Pages 57-64 doi: 10.1016/j.eng.2021.11.012

Abstract:

Hepatic malignancy is a major indication for liver transplantation; however, post-transplant cancer recurrence is an emerging clinical challenge affecting long-term outcomes. Pre-transplant tumor biology, staging, and post-transplant immunosuppression regimens have been elucidated as risk factors for recurrent liver cancer. However, increasing evidence indicates that hepatic ischemia and reperfusion (IR) injury to allografts are crucial to providing a favorable immunologic microenvironment for cancer cell invasiveness and metastasis after liver transplantation. The association of severe graft injury in marginal grafts, such as small-for-size or fatty grafts, with lower recurrence-free survival rates in living donor liver transplantations, substantiates the correlation between hepatic IR injury and cancer recurrence. IR have been demonstrated to trigger intrahepatic immunological microenvironment remodeling, including pro-inflammatory responses exacerbating graft injury and anti-inflammatory responses promoting tissue repair. However, the role of regional immunity in post-transplant cancer recurrence is not comprehensively understood. This review describes the up-to-date evidence of the intrahepatic humoral microenvironment and regional regulatory immunological microenvironment induced by IR injury, as well as their roles in cancer recurrence after liver transplantation. A comprehensive understanding of regional immunity will provide novel precise diagnostic, therapeutic, and prognostic strategies for post-transplant cancer recurrence.

Keywords: Liver transplantation     Liver cancer     Recurrence     Immunology    

British Society for Immunology Congress 2019

Conference Date: 2 Dec 2019

Conference Place: 英国/英格兰/利物浦

Administered by: British Society for Immunology

17th International Congress of Immunology

Conference Date: 19 Oct 2019

Conference Place: 中国/北京/朝阳

Administered by: 国际免疫学联合会;中国免疫学会

Nature Conference

Conference Date: 11 Jun 2019

Conference Place: 中国/山东/青岛

Administered by: 中国免疫学会;《自然-免疫学》;《中国免疫学会英文会刊(细胞与分子免疫学)》

Spring Cold Harbor Asia

Conference Date: 8 Apr 2019

Conference Place: 中国/江苏/苏州

Administered by: 冷泉港亚洲

IVIS 2019

Conference Date: 13 Aug 2019

Conference Place: 美国/华盛顿/西雅图

Administered by: International Union of Immunological Societies (IUIS) Veterinary Immunology Committee

第三届中英免疫学高峰论坛

Conference Date: 6 Dec 2019

Conference Place: 英国/英格兰/利物浦

Administered by: 英国免疫学会;中国免疫学会

Title Author Date Type Operation

Application of StrucGP in medical immunology: site-specific -glycoproteomic analysis of macrophages

Journal Article

Achievements in burn surgery over the past 50 years in China

WANG Shiliang

Journal Article

Mechanism of arterial remodeling in chronic allograft vasculopathy

Qichang Zheng, Shanglong Liu, Zifang Song

Journal Article

Role of Intrahepatic Regional Immunity in Post-Transplant Cancer Recurrence

Jiang Liu,Chung Mau Lo,Kwan Man

Journal Article

British Society for Immunology Congress 2019

2 Dec 2019

Conference Information

17th International Congress of Immunology

19 Oct 2019

Conference Information

Nature Conference

11 Jun 2019

Conference Information

Spring Cold Harbor Asia

8 Apr 2019

Conference Information

IVIS 2019

13 Aug 2019

Conference Information

第三届中英免疫学高峰论坛

6 Dec 2019

Conference Information