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Immunosuppression and Liver Transplantation Review

Jan Lerut, Samuele Iesari

Engineering 2023, Volume 21, Issue 2,   Pages 175-187 doi: 10.1016/j.eng.2022.07.007

Abstract:

Perfect surgical techniques and adequate immunosuppression are key toconsiderable and conceptually diverse study designs have failed to afford a clear definition of the optimal immunosuppressionand short-term steroids—beyond possible induction—remains the currently accepted standard immunosuppressionof rejection, customization of the immunosuppressive load, and long-term side effects due to chronic immunosuppressionBoth elements are critical to progress toward more prudent immunosuppression handling and favor clinical

Keywords: Liver transplantation     Immunosuppression     Rejection     Tolerance     Clinical trial    

Autoimmune hepatitis

Farhad Sahebjam,John M. Vierling

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 187-219 doi: 10.1007/s11684-015-0386-y

Abstract: Immunosuppression is most often successful using prednisone or prednisolone and azathioprine; howeverPatients failing standard immunosuppression are candidates for alternative immunosuppressive regimens

Keywords: autoimmune hepatitis     autoantibodies     diagnosis     immunological diseases     drug-induced liver injury     therapy     immunosuppression    

Chimeric Antigen Receptors and Regulatory T Cells: The Potential for HLA-Specific Immunosuppression in Review

Sabrina Wright, Conor Hennessy, Joanna Hester, Fadi Issa

Engineering 2022, Volume 10, Issue 3,   Pages 30-43 doi: 10.1016/j.eng.2021.10.018

Abstract:

Chimeric antigen receptors (CARs) are a breakthrough in genetic engineering that have revolutionized the field of adoptive cellular therapy (ACT). Cells expressing these receptors are rerouted to a predefined target by the inclusion of an antigen-specific binding region within the synthetic CAR construct. The advantage of cells with programmed specificity has been demonstrated clinically in the field of oncology, and it is clear that such cells have greater accuracy, potency, and reduced off-target therapeutic effects compared with their unmodified counterparts. In contrast to conventional T cells (Tconvs), regulatory T cells (Tregs) play a major role in suppressing immune activation and regulating the host immune response. CAR expression within Tregs has been proposed as a therapy for autoimmune and inflammatory diseases, graft-versus-host disease (GvHD), and organ transplant rejection. In the latter, they hold immense potential as mediators of immune tolerance for recipients of allotransplants. However, current research into CAR-Treg engineering is extremely limited, and there is uncertainty regarding optimal design for therapeutic use. This review examines the rationale behind the development of CAR-Tregs, their significance for human transplantation, potential designs, safety considerations, and comparisons of CAR-Tregs in transplantation models to date.

Keywords: Chimeric antigen receptors     T cell     Treg     Alloimmunity     Bioengineering     Transplant     Autoimmunity    

Importance of Viral Disease in Dairy Cow Fertility Review

D. Claire Wathes, Chike F. Oguejiofor, Carole Thomas, Zhangrui Cheng

Engineering 2020, Volume 6, Issue 1,   Pages 26-33 doi: 10.1016/j.eng.2019.07.020

Abstract: Fertility may also be reduced by BVDV-induced immunosuppression, which increases the susceptibility to

Keywords: diarrhea virus     Bovine herpesvirus-1     Bovine herpesvirus-4     Schmallenberg virus     Bluetongue virus     Immunosuppression    

In Vivo Development of Fetal Pig Kidneys in Mature Monkeys Under Clinically Approved Immunosuppressant Drugs Article

Tsuyoshi Takamura, Kenji Matsui, Naoto Matsumoto, Yatsumu Saito, Toshinari Fujimoto, Susumu Tajiri, Shuichiro Yamanaka, Kei Matsumoto, Akimitsu Kobayashi, Izumi Yamamoto, Hiroshi Sasaki, Haruyuki Hirayama, Hitomi Matsunari, Kazuaki Nakano, Hiroshi Nagashima, Akihiko Kiyoshi, Takao Kuroda, Makoto Inoue, Takeshi Miyawaki, Takashi Yokoo, Eiji Kobayashi

Engineering 2022, Volume 10, Issue 3,   Pages 65-73 doi: 10.1016/j.eng.2022.02.001

Abstract: Immunosuppression was performed with only US Food and Drug Administration-approved drugs.

Keywords: Cynomolgus monkey     Pig     Kidney     Fetal kidney     Immunosuppression    

Title Author Date Type Operation

Immunosuppression and Liver Transplantation

Jan Lerut, Samuele Iesari

Journal Article

Autoimmune hepatitis

Farhad Sahebjam,John M. Vierling

Journal Article

Chimeric Antigen Receptors and Regulatory T Cells: The Potential for HLA-Specific Immunosuppression in

Sabrina Wright, Conor Hennessy, Joanna Hester, Fadi Issa

Journal Article

Importance of Viral Disease in Dairy Cow Fertility

D. Claire Wathes, Chike F. Oguejiofor, Carole Thomas, Zhangrui Cheng

Journal Article

In Vivo Development of Fetal Pig Kidneys in Mature Monkeys Under Clinically Approved Immunosuppressant Drugs

Tsuyoshi Takamura, Kenji Matsui, Naoto Matsumoto, Yatsumu Saito, Toshinari Fujimoto, Susumu Tajiri, Shuichiro Yamanaka, Kei Matsumoto, Akimitsu Kobayashi, Izumi Yamamoto, Hiroshi Sasaki, Haruyuki Hirayama, Hitomi Matsunari, Kazuaki Nakano, Hiroshi Nagashima, Akihiko Kiyoshi, Takao Kuroda, Makoto Inoue, Takeshi Miyawaki, Takashi Yokoo, Eiji Kobayashi

Journal Article

Han Jun: Interpretation of the Frontier Progress of Immunosuppression and Escape Mechanism of Important

22 Dec 2022

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