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Apigenin alleviates neomycin-induced oxidative damage via the Nrf2 signaling pathway in cochlear hair

Frontiers of Medicine 2022, Volume 16, Issue 4, Pages 637-650 doi: 10.1007/s11684-021-0864-3

Abstract: Further evidence suggested that the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathwayDisruption of the Nrf2 axis abolished the effects of apigenin on the alleviation of oxidative stress

Keywords： apigenin aminoglycosides ototoxicity oxidative stress Nrf2 signaling pathway

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Triterpenoid inducers of Nrf2 signaling as potential therapeutic agents in sickle cell disease: a review

Amma Owusu-Ansah,Sung Hee Choi,Agne Petrosiute,John J. Letterio,Alex Yee-Chen Huang

Frontiers of Medicine 2015, Volume 9, Issue 1, Pages 46-56 doi: 10.1007/s11684-015-0375-1

Abstract: The transcription factor nuclear erythroid derived- 2 related factor 2 (Nrf2) controls the expressionThis review article is focused on triterpenoids that activate Nrf2, and their potential for reducing

Keywords： oxidative stress Nrf2 triterpenoids sickle cell disease vaso-occlusion CDDO-Me

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The Biofunctions of Phytochemicals and Their Applications in Farm Animals: The Nrf2/Keap1 System as a

Si Qin, De-Xing Hou

Engineering 2017, Volume 3, Issue 5, Pages 738-752 doi: 10.1016/J.ENG.2017.03.011

Abstract: The nuclear factor (erythroid-derived 2)-like 2/Kelch-like ECH-associated protein 1 (Nrf 2/Keap1) system2-mediated phase II enzymes in a variety of ways.2/Keap1 system.on the growth performance, meat quality, and intestinal microbiota of farm animals via targeting the Nrf2/Keap1 system.

Keywords： Phytochemical Biofunction Nrf 2/Keap1 system Growth performance Meat quality Intestinal microbiota

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obtained from grape seeds against bisphenol AF neurotoxicity via antioxidative effects mediated by the Nrf2

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 7, Pages 976-989 doi: 10.1007/s11705-022-2237-0

Abstract: The results demonstrated that the half maximal inhibitory concentration for scavenging 2,2-diphenyl-1seed lignin induced protective effects on BPAF-injured NE-4C cells via the nuclear factor erythroid 2-related Factor 2 pathway.

Keywords： grape seed lignin structure antioxidant NE-4C cells neuroprotection