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Rare tumors: a blue ocean of investigation

Frontiers of Medicine 2023, Volume 17, Issue 2, Pages 220-230 doi: 10.1007/s11684-023-0984-z

Abstract: Advances in novel drugs, therapies, and genetic techniques have revolutionized the diagnosis and treatment of cancers, substantially improving cancer patients’ prognosis. Although rare tumors account for a non-negligible number, the practice of precision medicine and development of novel therapies are largely hampered by many obstacles. Their low incidence and drastic regional disparities result in the difficulty of informative evidence-based diagnosis and subtyping. Sample exhaustion due to difficulty in diagnosis also leads to a lack of recommended therapeutic strategies in clinical guidelines, insufficient biomarkers for prognosis/efficacy, and inability to identify potential novel therapies in clinical trials. Herein, by reviewing the epidemiological data of Chinese solid tumors and publications defining rare tumors in other areas, we proposed a definition of rare tumor in China, including 515 tumor types with incidences of less than 2.5/100 000 per year. We also summarized the current diagnosis process, treatment recommendations, and global developmental progress of targeted drugs and immunotherapy agents on the status quo. Lastly, we pinpointed the current recommendation chance for patients with rare tumors to be involved in a clinical trial by NCCN. With this informative report, we aimed to raise awareness on the importance of rare tumor investigations and guarantee a bright future for rare tumor patients.

Keywords： rare tumors diagnosis flowchart treatment strategy clinical trials recommendation

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Satellite ocean exploration of space in China

Jiang Xingwei,Lin Mingsen,Liu Jianqiang

Strategic Study of CAE 2008, Volume 10, Issue 6, Pages 56-62

Abstract:

This article reviews the developing tendency about the ocean explorationIt looks back the developed status on the ocean satellite remote sensing technology, compares the domesticocean remote sensing technology with overseas status simply and gives their differences.The first developing keystone about ocean remote sensing is to launch subsequence HY-1 satellite andThe satellite application will be stress on monitoring the ocean disaster such as red tide, overflow

Keywords： ocean satellite remote sensing great power of ocean

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Variability and vulnerability of carbon pools in Southern Ocean and western Arctic Ocean and their exploratory

Chen Liqi

Strategic Study of CAE 2009, Volume 11, Issue 10, Pages 79-85

Abstract: conducted out underway sea-air pCO₂ and its relative parameters measurements in the Southern Oceanand the western Arctic Ocean for 10 years.

Keywords： carbon cycle variability and vulnerability Southern Ocean Arctic Ocean exploring engineering technology

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on improved performance of an innovative method of using heave response of a non-floating object for ocean

Srinivasan CHANDRASEKARAN, Arunachalam AMARKARTHIK, Karuppan SIVAKUMAR, Dhanasekaran SELVAMUTHUKUMARAN, Shaji SIDNEY

Frontiers in Energy 2013, Volume 7, Issue 3, Pages 279-287 doi: 10.1007/s11708-013-0268-4

Abstract: Up to the present, no studies have been done to harness ocean waves using a non-floating object and to

Keywords： ocean wave energy point absorbers heaving body non-floating object heave response ratio artificial neural

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Effects of thermocline on performance of underwater glider’s power system propelled by ocean thermal

Hai YANG, Jie MA,

Frontiers in Energy 2009, Volume 3, Issue 4, Pages 472-479 doi: 10.1007/s11708-009-0052-7

Abstract: A less time efficiency of operation is unfavorable to the thermal glider to penetrate through the ocean

Keywords： mathematical underwater glider system working certain corresponding threshold

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Advances on the application of ocean color remote sensing engineering in China

Pan Delu,Bai Yan

Strategic Study of CAE 2008, Volume 10, Issue 9, Pages 14-24

Abstract: style="text-align: justify;">After many years' endeavor of research and application practice, the oceanWith the aim of operational service, several kinds of ocean color remote sensing monitoring systems havefour major technical advances are describing, including 1) the radiative transfer principle of the oceancolor satellites; 3) ocean optical research in China Sea and the study of semi-analysis algorithm ofSecondly, On the foundation of technical advances, ocean color remote sensing takes effect on marine

Keywords： ocean color remote sensing operational application system Chinese ocean color satellite series HY-1A

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A review on front end conversion in ocean wave energy converters

Nagulan SANTHOSH,Venkatesan BASKARAN,Arunachalam AMARKARTHIK

Frontiers in Energy 2015, Volume 9, Issue 3, Pages 297-310 doi: 10.1007/s11708-015-0370-x

Abstract: Harvesting the energy from ocean waves is one of the greatest attractions for energy engineers and scientistsTill date, plenty of methods have been adopted to harvest the energy from the ocean waves.economical complexity, it is intricate to involve the majority of these energy harvesters in the real ocean

Keywords： wave energy converter point absorbers power take off (PTO) front end energy conversion

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From Remotely Operated Vehicles to Autonomous Undersea Vehicles

Feng Xisheng

Strategic Study of CAE 2000, Volume 2, Issue 12, Pages 29-33

Abstract:

A clear definition and a very fine classification of the unmanned undersea vehicles are given in this paper. Following a brief introduction of the advances on the unmanned undersea vehicles the paper points out that the autonomous underwater vehicles at present is a hot spot in the research realm of the unmanned undersea vehicles. This paper describes the research and development achievements pertinent to the unmanned undersea vehicles in Shenyang Institute of Automation (SIA), Chinese Academy of Sciences with the cooperation of organizations home and abroad in the last two decades. SIA started to be engaged in the research and development of the remotely operated tethered vehicles in the end of 1970's. This paper gives a wide introduction of the critical characteristics and technical descriptions of the first remotely operated tethered vehicle “HR- 01” in China, the first autonomous underwater vehicle “Explorer” and the autonomous underwater vehicle CR-01 (6 000 m).

Keywords： undersea vehicles ROV AUV ocean engineer ocean resources exploration

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An Exploration of Development of Construction Device for Ocean Engineering Equipment

Peng Tao, Lin Zhongqin, Yang Jianmin, Liu Cungen

Strategic Study of CAE 2016, Volume 18, Issue 4, Pages 109-112 doi: 10.15302/J-SSCAE-2016.04.016

Abstract:

With the developing of large scale and deep-water, performance of ocean engineering equipment hasAnd provide the support for the development of the construction capacity of ocean engineering equipment

Keywords： ocean engineering equipment construction device manufacturing technology

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Materials for Hydropower Engineering Applications: Turbines, Bearings, Sealing, Dams and Waterways, and Ocean Review

Emanuele Quaranta, Peter Davies

Engineering 2022, Volume 8, Issue 1, Pages 148-158 doi: 10.1016/j.eng.2021.06.025

Abstract: on the following categories: novel materials for turbines, dams and waterways, bearings, seals, and ocean

Keywords： Bearing Composite Dam Hydropower Material Ocean Seal Turbine

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Study on retrieval algorithm of ocean parameters for the HY-2 scanning microwave radiometer

Wang Zhenzhan,Bao Jinghua,Li Yun,Shen Hua

Strategic Study of CAE 2014, Volume 16, Issue 6, Pages 70-82

Abstract: wind speed shows that the algorithm is feasible and reasonable，which can retrieve the atmospheric and ocean

Keywords： HY-2 satellite scanning microwave radiometer ocean parameter retrieval algorithm

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View and Comments on the Data Ecosystem: “Ocean of Data”

Zi-Kui Liu

Engineering 2020, Volume 6, Issue 6, Pages 604-608 doi: 10.1016/j.eng.2020.04.009

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Active and passive microwave remote sensing technology of the HY-2A ocean satellite mission

Jiang Xingwei,Lin Mingsen,Song Qingtao

Strategic Study of CAE 2013, Volume 15, Issue 7, Pages 4-11

Abstract: significant breakthrough for microwave remote sensing technology of China, a milestone for China's own oceansatellite that plays a crucial role in maritime applications, and a role model for China's future ocean

Keywords： HY-2A satellite microwave remote sensing ocean remote sensing radar altimeter microwave scatterometry

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Reactive Extrusion (REx): Using Chemistry and Engineering to Solve the Problem of Ocean Plastics

Philippe Dubois

Engineering 2022, Volume 14, Issue 7, Pages 15-18 doi: 10.1016/j.eng.2021.12.009

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Marine Renewable Energy Seascape Review

Alistair G. L. Borthwick

Engineering 2016, Volume 2, Issue 1, Pages 69-78 doi: 10.1016/J.ENG.2016.01.011

Abstract: Ocean energy has huge potential, but there are major interdisciplinary problems to be overcome regardingThis article briefly reviews ocean energy production from offshore wind, tidal stream, ocean current,

Keywords： Marine renewable energy Offshore wind Tidal stream Ocean current Tidal range Wave energy Ocean thermal