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Risk factors for ventilator-associated pneumonia among patients undergoing major oncological surgery
Yutao Liu, Yaxia Di, Shuai Fu
Frontiers of Medicine 2017, Volume 11, Issue 2, Pages 239-246 doi: 10.1007/s11684-017-0509-8
Keywords: ventilator-associated pneumonia (VAP) pneumonia risk factors surgery for head and neck cancer (SHNC)
Analysis of antibiotic usage for viral community-acquired pneumonia in adults
Rongmeng Jiang, Bing Han, Chang Dou, Fei Zhou, Bin Cao, Xingwang Li
Frontiers of Medicine 2021, Volume 15, Issue 1, Pages 139-143 doi: 10.1007/s11684-019-0736-2
Keywords: adult antibiotic viral pneumonia
Frontiers of Medicine 2022, Volume 16, Issue 3, Pages 378-388 doi: 10.1007/s11684-021-0840-y
Keywords: severe Mycoplasma pneumoniae pneumonia children proteomics Fc fragment of the IgG-binding protein
Frontiers of Medicine 2022, Volume 16, Issue 3, Pages 389-402 doi: 10.1007/s11684-021-0856-3
Keywords: severe community-acquired pneumonia lung microbiota clinical improvements 7-category ordinal scale
Mouth the mirror of lungs: where does the connection lie?
Jananni Muthu,Sivaramakrishnan Muthanandam,Jaideep Mahendra
Frontiers of Medicine 2016, Volume 10, Issue 4, Pages 405-409 doi: 10.1007/s11684-016-0476-5
Periodontitis is the chronic destructive disease of the periodontium (Gums) caused by host bacterial interactions. The effect of such host bacterial interactions in oral cavity also evokes a systemic response. Numerous studies have found common mechanisms of destruction for periodontal diseases and other chronic diseases like diabetes mellitus, atherosclerosis, respiratory diseases, and adverse pregnancy outcomes. Oral colonization by respiratory pathogens appears to be a risk factor for development of respiratory diseases and oral interventions aimed at reducing oral bacterial count have resulted in reduced incidence of these reparatory illness. This reflects the importance of oral hygiene among patients with respiratory illness. This review highlights the association between periodontal diseases and respiratory diseases.
Keywords: periodontitis respiratory diseases acute pneumonia COPD
Fengxue Zhu, Xiujuan Zhao, Tianbing Wang, Zhenzhou Wang, Fuzheng Guo, Haiyan Xue, Panpan Chang, Hansheng Liang, Wentao Ni, Yaxin Wang, Lei Chen, Baoguo Jiang
Engineering 2021, Volume 7, Issue 3, Pages 367-375 doi: 10.1016/j.eng.2020.09.007
Keywords: Coronavirus disease 2019 Lung ultrasound Pneumonia
A Deep Learning System to Screen Novel Coronavirus Disease 2019 Pneumonia Article
Xiaowei Xu, Xiangao Jiang, Chunlian Ma, Peng Du, Xukun Li, Shuangzhi Lv, Liang Yu, Qin Ni, Yanfei Chen, Junwei Su, Guanjing Lang, Yongtao Li, Hong Zhao, Jun Liu, Kaijin Xu, Lingxiang Ruan, Jifang Sheng, Yunqing Qiu, Wei Wu, Tingbo Liang, Lanjuan Li
Engineering 2020, Volume 6, Issue 10, Pages 1122-1129 doi: 10.1016/j.eng.2020.04.010
Keywords: Coronavirus disease 2019 pneumonia COVID-19 Location-attention classification model Computed tomography
Fanghua Gong, Yong Xiong, Jian Xiao, Li Lin, Xiaodong Liu, Dezhong Wang, Xiaokun Li
Frontiers of Medicine 2020, Volume 14, Issue 2, Pages 220-224 doi: 10.1007/s11684-020-0755-z
Keywords: COVID-19 novel coronavirus pneumonia 2019-nCoV epidemic management
Shikai Song, Wenjuan He, Dawei Yang, Manar Benmouffok, Yao Wang, Jiyun Li, Chengtao Sun, Xiangbin Song, Shizhen Ma, Chang Cai, Shuangyang Ding, Congming Wu, Zhangqi Shen, Yang Wang,
Engineering 2022, Volume 10, Issue 3, Pages 146-154 doi: 10.1016/j.eng.2021.01.015
Klebsiella pneumoniae (K. pneumonia, KpI) is a predominate
Keywords: Clinical mastitis Klebsiella pneumonia Molecular characteristics Population structure Antimicrobial
Differences in Immunoglobulin G Glycosylation Between Influenza and COVID-19 Patients Article
Marina Kljaković-Gašpić Batinjan, Tea Petrović, Frano Vučković, Irzal Hadžibegović, Barbara Radovani, Ivana Jurin, Lovorka Đerek, Eva Huljev, Alemka Markotić, Ivica Lukšić, Irena Trbojević-Akmačić, Gordan Lauc, Ivan Gudelj, Rok Čivljak
Engineering 2023, Volume 26, Issue 7, Pages 54-62 doi: 10.1016/j.eng.2022.08.007
The essential role of immunoglobulin G (IgG) in immune system regulation and combatting infectious diseases cannot be fully recognized without an understanding of the changes in its N-glycans attached to the asparagine 297 of the Fc domain that occur under such circumstances. These glycans impact the antibody stability, half-life, secretion, immunogenicity, and effector functions. Therefore, in this study, we analyzed and compared the total IgG glycome—at the level of individual glycan structures and derived glycosylation traits (sialylation, galactosylation, fucosylation, and bisecting N-acetylglucosamine (GlcNAc))—of 64 patients with influenza, 77 patients with coronavirus disease 2019 (COVID-19), and 56 healthy controls. Our study revealed a significant decrease in IgG galactosylation, sialylation, and bisecting GlcNAc (where the latter shows the most significant decrease) in deceased COVID-19 patients, whereas IgG fucosylation was increased. On the other hand, IgG galactosylation remained stable in influenza patients and COVID-19 survivors. IgG glycosylation in influenza patients was more time-dependent: In the first seven days of the disease, sialylation increased and fucosylation and bisecting GlcNAc decreased; in the next 21 days, sialylation decreased and fucosylation increased (while bisecting GlcNAc remained stable). The similarity of IgG glycosylation changes in COVID-19 survivors and influenza patients may be the consequence of an adequate immune response to enveloped viruses, while the observed changes in deceased COVID-19 patients may indicate its deviation.
Keywords: Influenza COVID-19 Viral infection Glycosylation Immunoglobulin G Pneumonia
The Efficacy and Safety of Triazavirin for COVID-19: A Trial Protocol Protocol
Xiaoke Wu, Kaijiang Yu, Yongchen Wang, Wanhai Xu, Hongli Ma, Yan Hou, Yue Li, Benzhi Cai, Liying Zhu, Min Zhang, Xiaoli Hu, Jingshu Gao, Yu Wang, Huichao Qin, Mingyan Zhao, Yong Zhang, Kang Li, Zhimin Du, Baofeng Yang
Engineering 2020, Volume 6, Issue 10, Pages 1199-1204 doi: 10.1016/j.eng.2020.06.011
The coronavirus disease 2019 (COVID-19), a pneumonia caused by a novel coronavirus, was reported in
Keywords: Coronavirus disease 2019 Pneumonia SARS-CoV-2 Triazavirin Efficacy Safety
Core Outcome Set for Clinical Trials on Coronavirus Disease 2019 (COS-COVID) Article
Xinyao Jin, Bo Pang, Junhua Zhang, Qingquan Liu, Zhongqi Yang, Jihong Feng, Xuezheng Liu, Lei Zhang, Baohe Wang, Yuhong Huang, Alice Josephine Fauci, Yuling Ma, Myeong Soo Lee, Wei’an Yuan, Yanming Xie, Jianyuan Tang, Rui Gao, Liang Du, Shuo Zhang, Hanmei Qi, Yu Sun, Wenke Zheng, Fengwen Yang, Huizi Chua, Keyi Wang, Yi Ou, Ming Huang, Yan Zhu, Jiajie Yu, Jinhui Tian, Min Zhao, Jingqing Hu, Chen Yao, Youping Li, Boli Zhang
Engineering 2020, Volume 6, Issue 10, Pages 1147-1152 doi: 10.1016/j.eng.2020.03.002
Since its outbreak in December 2019, a series of clinical trials on coronavirus disease 2019 (COVID-19) have been registered or carried out. However, the significant heterogeneity and less critical outcomes of such trials may be leading to a waste of research resources. This study aimed to develop a core outcome set (COS) for clinical trials on COVID-19 in order to tackle the outcome issues. The study was conducted according to the Core Outcome Measures in Effectiveness Trials (COMET) Handbook: Version 1.0, a guideline for COS development. A research group was set up that included experts in respiratory and critical medicine, traditional Chinese medicine (TCM), evidence-based medicine, clinical pharmacology, and statistics, in addition to medical journal editors. Clinical trial registry websites (www.chictr.org.cn and clinicaltrials.gov) were searched to retrieve clinical trial protocols and outcomes in order to form an outcome pool. A total of 78 clinical trial protocols on COVID-19 were included and 259 outcomes were collected. After standardization, 132 outcomes were identified within seven different categories, of which 58 were selected to develop a preliminary outcome list for further consensus. After two rounds of Delphi survey and one consensus meeting, the most important outcomes for the different clinical classifications of COVID-19 were identified and determined to constitute the COS for clinical trials on COVID-19 (COS-COVID). The COS-COVID includes one outcome for the mild type (time to 2019 novel coronavirus (2019-nCoV) reverse transcription-polymerase chain reaction (RT-PCR) negativity), four outcomes for the ordinary type (length of hospital stay, composite events, score of clinical symptoms, and time to 2019-nCoV RT-PCR negativity), five outcomes for the severe type (composite events, length of hospital stay, arterial oxygen partial pressure (PaO2)/fraction of inspired oxygen (FiO2), duration of mechanical ventilation, and time to 2019-nCoV RT-PCR negativity), one outcome for critical type (all-cause mortality), and one outcome for rehabilitation period (pulmonary function). The COS-COVID is currently the most valuable and practical clinical outcome set for the evaluation of intervention effect, and is useful for evidence assessment and decision-making. With a deepening understanding of COVID-19 and application feedback, the COS-COVID should be continuously updated.
Keywords: Novel coronavirus pneumonia Core outcome set COVID-19 2019-nCoV Coronavirus disease Clinical trials
Title Author Date Type Operation
Risk factors for ventilator-associated pneumonia among patients undergoing major oncological surgery
Yutao Liu, Yaxia Di, Shuai Fu
Journal Article
Analysis of antibiotic usage for viral community-acquired pneumonia in adults
Rongmeng Jiang, Bing Han, Chang Dou, Fei Zhou, Bin Cao, Xingwang Li
Journal Article
Proteomics study of Mycoplasma pneumoniae pneumonia reveals the Fc fragment of the IgG-binding protein
Journal Article
microbiota and important taxa predicting clinical prognosis in patients with severe community-acquired pneumonia
Journal Article
Mouth the mirror of lungs: where does the connection lie?
Jananni Muthu,Sivaramakrishnan Muthanandam,Jaideep Mahendra
Journal Article
Ultrasonic Characteristics and Severity Assessment of Lung Ultrasound in COVID-19 Pneumonia: A Retrospective
Fengxue Zhu, Xiujuan Zhao, Tianbing Wang, Zhenzhou Wang, Fuzheng Guo, Haiyan Xue, Panpan Chang, Hansheng Liang, Wentao Ni, Yaxin Wang, Lei Chen, Baoguo Jiang
Journal Article
A Deep Learning System to Screen Novel Coronavirus Disease 2019 Pneumonia
Xiaowei Xu, Xiangao Jiang, Chunlian Ma, Peng Du, Xukun Li, Shuangzhi Lv, Liang Yu, Qin Ni, Yanfei Chen, Junwei Su, Guanjing Lang, Yongtao Li, Hong Zhao, Jun Liu, Kaijin Xu, Lingxiang Ruan, Jifang Sheng, Yunqing Qiu, Wei Wu, Tingbo Liang, Lanjuan Li
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China’s local governments are combating COVID-19 with unprecedented responses – from a Wenzhou governance perspective
Fanghua Gong, Yong Xiong, Jian Xiao, Li Lin, Xiaodong Liu, Dezhong Wang, Xiaokun Li
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Molecular Epidemiology of Klebsiella pneumoniae from Clinical Bovine Mastitis in Northern Area of China, 2018–2019
Shikai Song, Wenjuan He, Dawei Yang, Manar Benmouffok, Yao Wang, Jiyun Li, Chengtao Sun, Xiangbin Song, Shizhen Ma, Chang Cai, Shuangyang Ding, Congming Wu, Zhangqi Shen, Yang Wang,
Journal Article
Differences in Immunoglobulin G Glycosylation Between Influenza and COVID-19 Patients
Marina Kljaković-Gašpić Batinjan, Tea Petrović, Frano Vučković, Irzal Hadžibegović, Barbara Radovani, Ivana Jurin, Lovorka Đerek, Eva Huljev, Alemka Markotić, Ivica Lukšić, Irena Trbojević-Akmačić, Gordan Lauc, Ivan Gudelj, Rok Čivljak
Journal Article
Zhu zengyong: Pig Production Restoration and Industrial Form Analysis Under the Covid-19 Pneumonia Situation
18 Apr 2022
Conference Videos
The Efficacy and Safety of Triazavirin for COVID-19: A Trial Protocol
Xiaoke Wu, Kaijiang Yu, Yongchen Wang, Wanhai Xu, Hongli Ma, Yan Hou, Yue Li, Benzhi Cai, Liying Zhu, Min Zhang, Xiaoli Hu, Jingshu Gao, Yu Wang, Huichao Qin, Mingyan Zhao, Yong Zhang, Kang Li, Zhimin Du, Baofeng Yang
Journal Article
Core Outcome Set for Clinical Trials on Coronavirus Disease 2019 (COS-COVID)
Xinyao Jin, Bo Pang, Junhua Zhang, Qingquan Liu, Zhongqi Yang, Jihong Feng, Xuezheng Liu, Lei Zhang, Baohe Wang, Yuhong Huang, Alice Josephine Fauci, Yuling Ma, Myeong Soo Lee, Wei’an Yuan, Yanming Xie, Jianyuan Tang, Rui Gao, Liang Du, Shuo Zhang, Hanmei Qi, Yu Sun, Wenke Zheng, Fengwen Yang, Huizi Chua, Keyi Wang, Yi Ou, Ming Huang, Yan Zhu, Jiajie Yu, Jinhui Tian, Min Zhao, Jingqing Hu, Chen Yao, Youping Li, Boli Zhang
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