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Molecular characterization of two suppressor of cytokine signaling 1 genes (

Xue XU,Jiannan ZHANG,Juan LI,Yajun WANG

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 1,   Pages 73-83 doi: 10.15302/J-FASE-2015044

Abstract: Suppressor of cytokine signaling 1 (SOCS1) protein can inhibit the signal transduction triggered by some207-amino acid protein, which shares high amino acid sequence identity (64%–67%) with human and mouse SOCS1encode a 212-amino acid protein, which shares only 30%–32% amino acid sequence identity with human SOCS1and SOCS1b proteins can negatively regulate GH/PRL signaling.Taken together, these data suggest that both cSOCS1a and cSOCS1b may function as negative regulators

Keywords： chicken     SOCS1a     SOCS1b     growth hormone     prolactin    

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Ultraviolet-B induced expression of hypoxia-inducible factor 1α, transferrin receptor through EGFR/PI3K/AKT/DEC1 pathway

LI Yanhua, BI Zhigang

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 79-86 doi: 10.1007/s11684-007-0016-4

Abstract: The aim of this research was to explore the effects and signaling pathway of ultraviolet-B (UVB) irradiationon the expression of hypoxia-inducible factor 1α (HIF-1α) and transferrin receptor (TfR).The DEC1 (-/-) Ha-Cat cells did not increase their TfR and HIF-1α expressions following UVB irradiationIn contrast, DEC1 (+/+) HaCat cells strongly enhanced TfR and HIF-1?We conclude that UVB induces TfR and HIF-1αexpressions via EGFR/PI3K/AKT/DEC1 signaling pathway.
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Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 883-895 doi: 10.1007/s11684-022-0919-0

Abstract: We further examined the expression of the autophagy-related genes Beclin1 and LC3B in 82 patients throughimmunohistochemistry and found that Beclin1 and LC3B were highly related to unfavorable prognosis ofKnockdown of Beclin1 and LC3B reduced invasion, metastasis, and proliferation in metastatic osteosarcomademonstrated that autophagy-related genes were activated by SEs and that the inhibition of SEs by JQ-1

Keywords： osteosarcoma     autophagy     metastasis     drug resistance     Beclin1     LC3B    

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An Eight-Step Continuous-Flow Total Synthesis of Vitamin B1 Article

Meifen Jiang, Minjie Liu, Weijian Li, Yingqi Xia, Fener Chen

Engineering 2024, Volume 32, Issue 1,   Pages 230-239 doi: 10.1016/j.eng.2023.01.016

Abstract:

Vitamin B1 is widely applied in the healthcare and food industry as an antineuritic andThis study reports on an integrated eight-step continuous-flow synthesis of vitamin B1 fromVitamin B1 was produced with a separated yield of 47.7% and high purity, with a total residence

Keywords： Vitamin B1     Continuous-flow synthesis     Micro-reactor     Continuous manufacturing    

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Gene therapy for hemophilia B mice with scAAV8-LP1-hFIX

Wei Lu,Qingzhang Zhou,Hao Yang,Hao Wang,Yexing Gu,Qi Shen,Jinglun Xue,Xiaoyan Dong,Jinzhong Chen

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 212-218 doi: 10.1007/s11684-016-0438-y

Abstract:

Hemophilia B is a hemorrhagic disease caused by the deficiency of clotting factor IX (FIX).However, two main problems that should be solved in gene therapy for hemophilia B are immunity and safetyimmunogenicity and high transfection efficiency in liver cells, might be a potential vector for hemophilia BA strong liver-specific promoter-1 (LP1) was inserted and mutant human FIX Arg338Ala was introduced intoOur study provides a potential gene therapy method for hemophilia B.

Keywords： hemophilia B     AAV8     hFIX     gene therapy    

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Association of miRNA-122-binding site polymorphism at the interleukin-1 α gene and its interaction withhepatitis B virus mutations with hepatocellular carcinoma risk

Du Yan, Han Xue, Pu Rui, Xie Jiaxin, Zhang Yuwei, Cao Guangwen

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 217-226 doi: 10.1007/s11684-014-0326-2

Abstract: designed to investigate the contribution of miRNA-122-binding site polymorphism at the IL-1A gene and its multiplicative interactions with hepatitis B virus (HBV) mutations in the risk

Keywords： hepatocellular carcinoma (HCC)     interaction     miRNA-122-binding site     IL-1A     rs3783553     hepatitis B virus (    

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Netrin-1 works with UNC5B to regulate angiogenesis in diabetic kidney disease

Xiaojing Jiao, Dong Zhang, Quan Hong, Lei Yan, Qiuxia Han, Fengmin Shao, Guangyan Cai, Xiangmei Chen, Hanyu Zhu

Frontiers of Medicine 2020, Volume 14, Issue 3,   Pages 293-304 doi: 10.1007/s11684-019-0715-7

Abstract: Netrin-1, an axon guidance factor, and its receptor UNC5B play important roles in axonal developmentNetrin-1 and UNC5B were upregulated in streptozotocin-induced DKD Wistar rats, and their expression wasNetrin-1 treatment also eliminated the pro-angiogenic effects of exogenous VEGF-165 on UNC5B-silencedThese results indicate that UNC5B antagonizes netrin-1 and that UNC5B upregulation contributes partlyTherefore, introducing exogenous netrin-1 and depleting endogenous UNC5B are potential strategies for

Keywords： netrin-1     VEGF-165     UNC5B     angiogenesis     diabetic kidney disease    

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Loss of liver kinase B1 causes planar polarity defects in cochlear hair cells in mice

Yuqin Men,Aizhen Zhang,Liwen Zhang,Yecheng Jin,Zhishuo Wang,Jing Zhao,Xiaolin Yu,Jian Zhang,Jiangang Gao

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 481-489 doi: 10.1007/s11684-016-0494-3

Abstract:

The tumor suppressor gene liver kinase B1 (LKB1), also called STK11, encodes a serine/threonine kinaseLKB1 plays crucial roles in cell differentiation, proliferation, and polarity.In this study, LKB1 conditional knockout mice (LKB1Pax2 CKO mice) were generated usingLKB1Pax2 CKO mice died perinatally.LKB1 deficiency in LKB1Pax2 CKO mice thus disrupted hair cell planar polarity during

Keywords： LKB1     stereociliary bundles     kinocilium     planar cell polarity     hearing     mice    

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Three-dimensional face point cloud hole-filling algorithm based on binocular stereo matching and a B-spline Research Articles

Yuan HUANG, Feipeng DA,whhbb@163.com

Frontiers of Information Technology & Electronic Engineering 2022, Volume 23, Issue 3,   Pages 398-408 doi: 10.1631/FITEE.2000508

Abstract: When obtaining three-dimensional (3D) face point cloud data based on structured light, factors related to the environment, occlusion, and illumination intensity lead to holes in the collected data, which affect subsequent recognition. In this study, we propose a hole-filling method based on stereo-matching technology combined with a . The algorithm uses phase information acquired during raster projection to locate holes in the point cloud, simultaneously extracting boundary point cloud sets. By registering the face point cloud data using the stereo-matching algorithm and the data collected using the raster projection method, some supplementary information points can be obtained at the holes. The shape of the curve can then be roughly described by a few key points, and the control points are put into the hole area as key points for iterative calculation of surface reconstruction. Simulations using smooth ceramic cups and human face models showed that our model can accurately reproduce details and accurately restore complex shapes on the test surfaces. Simulation results indicated the robustness of the method, which is able to fill holes on complex areas such as the inner side of the nose without a prior model. This approach also effectively supplements the hole information, and the patched point cloud is closer to the original data. This method could be used across a wide range of applications requiring accurate facial recognition.

Keywords： Three-dimensional (3D) point cloud     Hole filling     Stereo matching     B-spline    

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Irreversible phenotypic perturbation and functional impairment of B cells during HIV-1 infection

Jingjing Yan, Shuye Zhang, Jun Sun, Jianqing Xu, Xiaoyan Zhang

Frontiers of Medicine 2019, Volume 13, Issue 3,   Pages 409-409 doi: 10.1007/s11684-018-0618-z

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Design, synthesis, and antiviral properties of 2-aryl-1H-benzimidazole-4-carboxamide derivatives

Xianjin LUO, Zhonglü ZHANG, Yutian YANG, Fei XUE, Naiyun XIU, Yuanbin SHE

Frontiers of Chemical Science and Engineering 2009, Volume 3, Issue 3,   Pages 305-309 doi: 10.1007/s11705-009-0021-z

Abstract: better selective activity and inhibitory activity than the comparable ribavirin against Coxsackie virus B

Keywords： benzimidazole     coxsackie virus B3     antiviral properties    

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Research on HJ-1A/B satellites data automatic geometric precision correction design

Xiong Wencheng,Shen Wenming,Wang Qiao,Shi Yuanli,Xiao Rulin and Fu Zhuo

Strategic Study of CAE 2014, Volume 16, Issue 3,   Pages 37-42

Abstract:

HJ-1A/B satellites were developed independently by China，have operated well on-orbit for five yearsThe paper analyzed the parameter characteristics of HJ-1satellite and geometric features of HJ-1satelliteBased on this，the overall HJ-1multi- sensor geometric correction flow and charge-coupled device（CCD）automaticshowed that the method could achieve good result for automatic geometric precision correction of HJ-1satellitedata，automatic HJ-1CCD image geometric precision correction accuracy could be achieved within two pixels

Keywords： HJ-1satellite     automatic     geometric precision correction     CCD    

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Conserved Surface Polysaccharide Are Protective Against a Wide Range of Microbial Pathogens Producing β-1–

Xi Lu,Guoqing Li,Jing Pang,Xinyi Yang,Colette Cywes-Bentley,Xuefu You,Gerald B. Pier,

Engineering doi: 10.1016/j.eng.2023.09.012

Abstract: The β-1–6-linked poly-N-acetylglucosamine (PNAG) polymer is a conserved surface polysaccharide produced

Keywords： Poly-     N     -acetylglucosamine     Conjugate vaccine     Monoclonal antibody    

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Plasma spray coating on interconnector toward promoted solid oxide fuel cells and solid oxide electrolysis cells

Frontiers in Energy doi: 10.1007/s11708-023-0901-9

Abstract: Interconnector is a critical component to construct solid oxide cells (SOCs) stack.poisoning caused by oxidation are important factors that lead to long-term performance degradation of SOCs

Keywords： interconnector coating     plasma spray     electrochemical performance     Cr diffusion inhibition     solid oxide cells (SOCs    

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A simple umbelliferone based fluorescent probe for the detection of nitroreductase

Bull, Robert B. P. Elmes, Tony D. James

Frontiers of Chemical Science and Engineering 2018, Volume 12, Issue 2,   Pages 311-314 doi: 10.1007/s11705-017-1697-0

Abstract: A simple nitrobenzyl-umbelliferone (NCOU1) was synthesised containing a nitroreductase (NTR) triggerIn the presence of the NTR enzyme, NCOU1 gave rise to a 5-fold increase in fluorescence intensity atThese results indicate that NCOU1 can be used as a simple assay for the detection of NTR.

Keywords： fragmentation     NCOU1     NTR     nitroreductase     nitrobenzyl-umbelliferone    

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Title Author Date Type Operation

Molecular characterization of two suppressor of cytokine signaling 1 genes (

Xue XU,Jiannan ZHANG,Juan LI,Yajun WANG

Journal Article

Ultraviolet-B induced expression of hypoxia-inducible factor 1α, transferrin receptor through EGFR/PI3K/AKT/DEC1 pathway

LI Yanhua, BI Zhigang

Journal Article

Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance

Journal Article

An Eight-Step Continuous-Flow Total Synthesis of Vitamin B1

Meifen Jiang, Minjie Liu, Weijian Li, Yingqi Xia, Fener Chen

Journal Article

Gene therapy for hemophilia B mice with scAAV8-LP1-hFIX

Wei Lu,Qingzhang Zhou,Hao Yang,Hao Wang,Yexing Gu,Qi Shen,Jinglun Xue,Xiaoyan Dong,Jinzhong Chen

Journal Article

Association of miRNA-122-binding site polymorphism at the interleukin-1 α gene and its interaction withhepatitis B virus mutations with hepatocellular carcinoma risk

Du Yan, Han Xue, Pu Rui, Xie Jiaxin, Zhang Yuwei, Cao Guangwen

Journal Article

Netrin-1 works with UNC5B to regulate angiogenesis in diabetic kidney disease

Xiaojing Jiao, Dong Zhang, Quan Hong, Lei Yan, Qiuxia Han, Fengmin Shao, Guangyan Cai, Xiangmei Chen, Hanyu Zhu

Journal Article

Loss of liver kinase B1 causes planar polarity defects in cochlear hair cells in mice

Yuqin Men,Aizhen Zhang,Liwen Zhang,Yecheng Jin,Zhishuo Wang,Jing Zhao,Xiaolin Yu,Jian Zhang,Jiangang Gao

Journal Article

Three-dimensional face point cloud hole-filling algorithm based on binocular stereo matching and a B-spline

Yuan HUANG, Feipeng DA,whhbb@163.com

Journal Article

Irreversible phenotypic perturbation and functional impairment of B cells during HIV-1 infection

Jingjing Yan, Shuye Zhang, Jun Sun, Jianqing Xu, Xiaoyan Zhang

Journal Article

Design, synthesis, and antiviral properties of 2-aryl-1H-benzimidazole-4-carboxamide derivatives

Xianjin LUO, Zhonglü ZHANG, Yutian YANG, Fei XUE, Naiyun XIU, Yuanbin SHE

Journal Article

Research on HJ-1A/B satellites data automatic geometric precision correction design

Xiong Wencheng,Shen Wenming,Wang Qiao,Shi Yuanli,Xiao Rulin and Fu Zhuo

Journal Article

Conserved Surface Polysaccharide Are Protective Against a Wide Range of Microbial Pathogens Producing β-1–

Xi Lu,Guoqing Li,Jing Pang,Xinyi Yang,Colette Cywes-Bentley,Xuefu You,Gerald B. Pier,

Journal Article

Plasma spray coating on interconnector toward promoted solid oxide fuel cells and solid oxide electrolysis cells

Journal Article

A simple umbelliferone based fluorescent probe for the detection of nitroreductase

Bull, Robert B. P. Elmes, Tony D. James

Journal Article