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Research progress on FASN and MGLL in the regulation of abnormal lipid metabolism and the relationship

Jingyue Zhang, Yawen Song, Qianqian Shi, Li Fu

Frontiers of Medicine 2021, Volume 15, Issue 5,   Pages 649-656 doi: 10.1007/s11684-021-0830-0

Abstract: Tumorigenesis involves metabolic reprogramming and abnormal lipid metabolism, which is manifested byThis article introduces the structures and functions of FASN and MGLL, their relationship with abnormal

Keywords: FASN     MGLL     lipid metabolism     tumor invasion     metastasis    

Identification of abnormal operating conditions and intelligent decision system

Xiuliang LI, Junjie JIANG, Hongye SU, Jian CHU

Frontiers of Mechanical Engineering 2011, Volume 6, Issue 4,   Pages 456-462 doi: 10.1007/s11465-011-0224-0

Abstract: flow state” is difficult to form using the soil dug in the capsule because it can cause three abnormalThese abnormal operating conditions can, in turn, trigger failure in tunneling, cutter-device damage,This present paper effectively integrates the mechanism of abnormal operating conditions and knowledgeof soil conditioning, and establishes a uniform model of identifying abnormal conditions and intelligent

Keywords: earth pressure balance (EPB) shield machine     soil pressure cabin     abnormal operating condition     belief rule-base    

Feedback linearization based control for weak grid connected PV system under normal and abnormal conditions

Rahul SHARMA,Sathans SUHAG

Frontiers in Energy 2020, Volume 14, Issue 2,   Pages 400-409 doi: 10.1007/s11708-017-0459-5

Abstract: This paper proposes a control strategy for interface of distributed energy sources into the weak grid system with a focus on the energy and ancillary services. A novel controller has been designed and implemented to tackle the challenges of coupling terms in the LCL filter, the transient behavior under sudden changes, and the voltage support under fault condition using the feedback linearization technique. The controller proposed has been implemented on the PV system connected with the weak grid using the LCL filter and the performance of the controller has been verified using Matlab/Simulink through simulation under different conditions. The results of the controller proposed have been compared with the conventional PI dual loop controller. The simulation results obtained demonstrate the effectiveness and simplicity of the controller design strategy.

Keywords: PV system     grid interface     feedback linearization     inverter     LCL filter    

A knowledge reasoning Fuzzy-Bayesian network for root cause analysis of abnormal aluminum electrolysis

Weichao Yue, Xiaofang Chen, Weihua Gui, Yongfang Xie, Hongliang Zhang

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 3,   Pages 414-428 doi: 10.1007/s11705-017-1663-x

Abstract: Root cause analysis (RCA) of abnormal aluminum electrolysis cell condition has long been a challengingIn addition, accurate RCA of abnormal aluminum electrolysis cell condition is the precondition of improvingRCA of abnormal condition is a complex work of multi-source knowledge fusion, which is difficult to ensureThe method can effectively fuse and solidify the knowledge, which is used to analyze the cause of abnormalThe proposed method was verified under 20 sets of abnormal cell conditions, and implements root cause

Keywords: abnormal aluminum electrolysis cell condition     Fuzzy-Bayesian network     multi-source knowledge solidification    

AED-Net: An Abnormal Event Detection Network Article

Tian Wang, Zichen Miao, Yuxin Chen, Yi Zhou, Guangcun Shan, Hichem Snoussi

Engineering 2019, Volume 5, Issue 5,   Pages 930-939 doi: 10.1016/j.eng.2019.02.008

Abstract: In this paper, a self-supervised framework called the abnormal event detection network (AED-Net), whichExperiments in global and local abnormal event detection are carried out on Monitoring Human Activity

Keywords: Abnormal events detection     Abnormal event detection network     Principal component analysis network     Kernel    

Assessment of robustness of structures: Current state of research

Colin BRETT, Yong LU

Frontiers of Structural and Civil Engineering 2013, Volume 7, Issue 4,   Pages 356-368 doi: 10.1007/s11709-013-0220-z

Abstract: The concept of structural robustness and relevant design guidelines have been in existence in the progressive collapse literature since the 1970s following the partial collapse of the Ronan Point apartment building; however, in the more general context, research on the evaluation and enhancement of structural robustness is still relatively limited. This paper is aimed to provide a general overview of the current state of research concerning structural robustness. The focus is placed on the quantification and the associated evaluation methodologies, rather than specific measures to ensure prescriptive robustness requirements. Some associated concepts, such as redundancy and vulnerability, will be discussed and interpreted in the general context of robustness such that the corresponding methodologies can be compared quantitatively using a comparable scale. A framework methodology proposed by the authors is also introduced in line with the discussion of the literature.

Keywords: structural robustness     abnormal exposure     vulnerability     collapse     consequence    

Abnormal glycosylated hemoglobin as a predictive factor for glucose metabolism disorders in antipsychotic

XU Leping, JI Juying, DUAN Yiyang, SHI Hui, ZHANG Bin, SHAO Yaqin, SUN Jian

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 316-319 doi: 10.1007/s11684-007-0061-z

Abstract: to discuss the relationship between the occurrence of glucose metabolism disorders of APS origin and abnormaltolerance test (2HPG) were normal, were grouped according to the HbAc levels, one normal and the other abnormalIn the group with abnormal HbA1c and clozapine therapy, 2HPG was higher after the study [(9.5±1.8) mmolIn the abnormal HbAc group, 2HPG after the study was higher in the clozapine treatment group [(9.5±1.8Patients with abnormal HbAc are more likely to have a higher risk of having glucose metabolism disorders

Keywords: significant difference     occurrence     hemoglobin     risperidone treatment     abnormal    

Quantitative Investigation of Tomographic Effects in Abnormal Regions of Complex Structures Article

Longjun Dong, Xiaojie Tong, Ju Ma

Engineering 2021, Volume 7, Issue 7,   Pages 1011-1022 doi: 10.1016/j.eng.2020.06.021

Abstract:

The detection of abnormal regions in complex structures is one of the most challenging targets foremergence of real-time monitoring, seismic wave velocity tomography allows the detection and imaging of abnormalinput parameters based on quantization results can significantly improve the detection reliability in abnormal

Keywords: Detection of abnormal regions     Tomographic effects     Wave velocity     Ray path    

Determining “abnormal” levator hiatus distensibility using three-dimensional transperineal ultrasound

Chaoran Dou, Qin Li, Tao Ying, Yulin Yan, Xia Wang, Bing Hu

Frontiers of Medicine 2018, Volume 12, Issue 5,   Pages 572-579 doi: 10.1007/s11684-017-0561-4

Abstract: characteristic (ROC) curve analyses were performed to determine valid screening index for detecting abnormalarea (HA) of 19.5 cm2 during Valsalva maneuver can be used as single-screening index for abnormalAs a result, we suggest that HA≥19.5 cm2 during Valsalva maneuver is an indicator of abnormalhiatus distensibility in Chinese women and that the two-step method has higher sensitivity in detecting abnormal

Keywords: three-dimensional transperineal ultrasound     levator hiatus     levator ani muscle     pelvic organ prolapse    

Early Identification of Abnormal Regions in Rock-Mass Using Traveltime Tomography Article

Longjun Dong,Zhongwei Pei,Xin Xie,Yihan Zhang,Xianhang Yan

Engineering 2023, Volume 22, Issue 3,   Pages 191-200 doi: 10.1016/j.eng.2022.05.016

Abstract:

Early identification of abnormal regions is crucial in preventing the occurrence of underground geotechnicalhigh-accuracy detection requirements of underground engineering, this paper proposes a tomography method for abnormalThe results show that DSPM and FSM can clearly detect abnormal regions in numerical and laboratory experimentsThis paper not only realizes the application of abnormal region identification using traveltime tomography

Keywords: Underground engineering     Traveltime tomography     Complex structures     Abnormal region identification     Ray    

Presence of multiple abnormal immunologic markers is an independent prognostic factor of diffuse large

Yiwen Cao, Zhenhua Liu, Wen Wu, Ying Qian, Qin Shi, Rong Shen, Binshen Ouyang, Pengpeng Xu, Shu Cheng, Jin Ye, Yiming Lu, Chaofu Wang, Chengde Yang, Li Wang, Weili Zhao

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 94-103 doi: 10.1007/s11684-019-0680-1

Abstract: Among the patients, those with multiple (≥3) abnormal immunologic markers had significantly shorter 3vs. 77.3%, P<0.001) and OS (68.5% vs. 85.8%, P=0.001) than those without multiple abnormalMultivariate analysis revealed that the presence of multiple abnormal immunologic markers and the elevated

Keywords: immunologic marker     diffuse large B-cell lymphoma     prognosis    

Myocardial Ischemia by Activating Vascular Smooth Muscle Cell Soluble Guanylate Cyclase to Inhibit Abnormal

Shuang Yang,Yixiu Zhao,Xiaoling Cheng,Tingting Zhan,Jiaying Tian,Xue Liu,Chunyue Ma,Zhiqi Wang,Luying Jin,Qian Liu,Yanli Wang,Jian Huang,Jinhui Wang,Yan Zhang,Baofeng Yang,

Engineering doi: 10.1016/j.eng.2023.06.009

Abstract: Myocardial ischemia is a serious threat to human health, and vascular dysfunction is its main cause. Buxu Tongyu Granule (BXTY) is an effective traditional Chinese medicine (TCM) for treating myocardial ischemia. However, the underlying mechanism of BXTY is still unclear. In this study, we demonstrate that BXTY ameliorates myocardial ischemia by activating the soluble guanylate cyclase (sGC)–3′,5′-cyclic guanosine monophosphate (cGMP)–protein kinase G (PKG) signaling pathway in vascular smooth muscle cells (VSMCs) to dilate the arteries. BXTY was given by gavage for ten consecutive days before establishing an animal model of acute myocardial ischemia in mice via the intraperitoneal injection of pituitrin. The results showed that BXTY alleviated the symptoms of myocardial ischemia induced by pituitrin in mice, including electrocardiogram abnormalities and changes in plasma enzymes. In addition, BXTY dilated pre-constricted blood vessels and inhibited the vasoconstriction of the superior mesenteric artery in a dose-dependent but endothelial-independent manner. These effects were eliminated by pre-incubating vascular rings with the sGC inhibitors NS 2028 or ODQ, or with the PKG inhibitor KT 5823. Moreover, BXTY increased the protein expression of sGC-β1 and the intracellular second messenger cGMP level in mouse aortic vascular smooth muscle cells (MOVAs). NS 2028 or ODQ reversed these effects of BXTY. The expression level of the cGMP downstream effector protein PKG-1 increased after treating MOVAs with BXTY. NS 2028, ODQ, or KT 5823 also reversed this effect of BXTY. In conclusion, BXTY can improve the symptoms of acute myocardial ischemia in mice, and activating the sGC–cGMP–PKG pathway in VSMCs to induce vasodilation is its key pharmacodynamic mechanism.

Keywords: Myocardial ischemia     Vasomotion     Soluble guanylate cyclase     Buxu Tongyu Granule    

Abnormal expression of c-Myc in human bronchial epithelial cells malignantly transformed by anti-BPDE

FU Juan, JIANG Yiguo, CHEN Xuemin

Frontiers of Medicine 2008, Volume 2, Issue 4,   Pages 380-385 doi: 10.1007/s11684-008-0073-3

Abstract: In conclusion, the abnormal expression of c-Myc was present in anti-BPDE malignantly transformed 16HBE

Keywords: transcriptase-polymerase     vehicle-treated     understood     molecular mechanism     different    

MAS-based production scheduling system for manufacturing cell-based workshop

CHU Hong-yan, CAO Quan-jun, FEI Ren-yuan

Frontiers of Mechanical Engineering 2006, Volume 1, Issue 4,   Pages 375-380 doi: 10.1007/s11465-006-0043-x

Abstract: The scheduling system also can deal with some abnormal conditions, such as machine tool failure and urgent

Keywords: negotiation     selection     multi-agent     communication     abnormal    

Emergency adult living donor right lobe liver transplantation for fulminant hepatic failure

ZHANG Feng, WANG Xuehao, LI Xiangcheng, KONG Lianbao, SUN Beicheng, LI Guoqiang, QIAN Xiaofen, CHEN Feng, WANG Ke, LU Sheng, PU Liyong, LU Ling

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 282-286 doi: 10.1007/s11684-007-0054-y

Abstract: The principal complications before transplantation included abnormal renal function, hepatic coma of

Keywords: alimentary     abnormal     hemorrhage     principal     different    

Title Author Date Type Operation

Research progress on FASN and MGLL in the regulation of abnormal lipid metabolism and the relationship

Jingyue Zhang, Yawen Song, Qianqian Shi, Li Fu

Journal Article

Identification of abnormal operating conditions and intelligent decision system

Xiuliang LI, Junjie JIANG, Hongye SU, Jian CHU

Journal Article

Feedback linearization based control for weak grid connected PV system under normal and abnormal conditions

Rahul SHARMA,Sathans SUHAG

Journal Article

A knowledge reasoning Fuzzy-Bayesian network for root cause analysis of abnormal aluminum electrolysis

Weichao Yue, Xiaofang Chen, Weihua Gui, Yongfang Xie, Hongliang Zhang

Journal Article

AED-Net: An Abnormal Event Detection Network

Tian Wang, Zichen Miao, Yuxin Chen, Yi Zhou, Guangcun Shan, Hichem Snoussi

Journal Article

Assessment of robustness of structures: Current state of research

Colin BRETT, Yong LU

Journal Article

Abnormal glycosylated hemoglobin as a predictive factor for glucose metabolism disorders in antipsychotic

XU Leping, JI Juying, DUAN Yiyang, SHI Hui, ZHANG Bin, SHAO Yaqin, SUN Jian

Journal Article

Quantitative Investigation of Tomographic Effects in Abnormal Regions of Complex Structures

Longjun Dong, Xiaojie Tong, Ju Ma

Journal Article

Determining “abnormal” levator hiatus distensibility using three-dimensional transperineal ultrasound

Chaoran Dou, Qin Li, Tao Ying, Yulin Yan, Xia Wang, Bing Hu

Journal Article

Early Identification of Abnormal Regions in Rock-Mass Using Traveltime Tomography

Longjun Dong,Zhongwei Pei,Xin Xie,Yihan Zhang,Xianhang Yan

Journal Article

Presence of multiple abnormal immunologic markers is an independent prognostic factor of diffuse large

Yiwen Cao, Zhenhua Liu, Wen Wu, Ying Qian, Qin Shi, Rong Shen, Binshen Ouyang, Pengpeng Xu, Shu Cheng, Jin Ye, Yiming Lu, Chaofu Wang, Chengde Yang, Li Wang, Weili Zhao

Journal Article

Myocardial Ischemia by Activating Vascular Smooth Muscle Cell Soluble Guanylate Cyclase to Inhibit Abnormal

Shuang Yang,Yixiu Zhao,Xiaoling Cheng,Tingting Zhan,Jiaying Tian,Xue Liu,Chunyue Ma,Zhiqi Wang,Luying Jin,Qian Liu,Yanli Wang,Jian Huang,Jinhui Wang,Yan Zhang,Baofeng Yang,

Journal Article

Abnormal expression of c-Myc in human bronchial epithelial cells malignantly transformed by anti-BPDE

FU Juan, JIANG Yiguo, CHEN Xuemin

Journal Article

MAS-based production scheduling system for manufacturing cell-based workshop

CHU Hong-yan, CAO Quan-jun, FEI Ren-yuan

Journal Article

Emergency adult living donor right lobe liver transplantation for fulminant hepatic failure

ZHANG Feng, WANG Xuehao, LI Xiangcheng, KONG Lianbao, SUN Beicheng, LI Guoqiang, QIAN Xiaofen, CHEN Feng, WANG Ke, LU Sheng, PU Liyong, LU Ling

Journal Article