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Halomonas bluephagenesis 1

α-acetolactate decarboxylase 1

α-acetolactate synthetase 1

acetoin 1

pyruvate 1

whole-cell biocatalysis 1

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Efficient acetoin production from pyruvate by engineered whole-cell biocatalysis

Frontiers of Chemical Science and Engineering   Pages 425-436 doi: 10.1007/s11705-022-2229-0

Abstract: Acetoin is an important platform chemical, which has a wide range of applications in many industries.decarboxylase from Bacillus subtilis 168 were co-expressed in H. bluephagenesis to produce acetoinreaction condition optimization and further increase of α-acetolactate decarboxylase expression, acetoinFinally, the highest titer of 974.3 mmol·L–1 (85.84 g·L–1) of acetoin was accumulatedH. bluephagenesis whole-cell catalysis with a broad development prospect in biosynthesis of acetoin

Keywords： acetoin     pyruvate     α-acetolactate synthetase     α-acetolactate decarboxylase     Halomonas    

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Efficient acetoin production from pyruvate by engineered whole-cell biocatalysis

Journal Article