Resource Type

Journal Article 20

Year

2023 3

2022 4

2017 1

2013 1

2010 1

2009 5

2008 3

2007 2

open ︾

Keywords

apoptosis 10

Apoptosis 2

concentration 2

lung cancer 2

3-AB 1

Salmonella VNP20009 1

in situ hydrophobic environment trigger 1

Autophagy 1

B16F10 1

Bay 11-7082 1

Beclin-1 1

CD437 1

Cell survival 1

EGFR inhibitor 1

ER-stress 1

FLICE-like inhibitory protein 1

Fas/FasL system 1

HL-60 1

Metabolism 1

open ︾

Search scope:

排序： Display mode:

Targeting apoptosis to manage acquired resistance to third generation EGFR inhibitors

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 701-713 doi: 10.1007/s11684-022-0951-0

Abstract: Apoptosis is a major type of programmed cell death tightly associated with cancer development and treatmentEvasion of apoptosis is considered a key hallmark of cancer and acquisition of apoptosis resistance isIt has been clearly shown that effective induction of apoptosis is a key mechanism for third generationparticularly osimertinib, to exert their therapeutic efficacies and the development of resistance to apoptosisHence, restoration of cell sensitivity to undergo apoptosis using various means promises an effective

Keywords： acquired resistance     EGFR inhibitor     apoptosis     lung cancer    

HTML PDF Collect

Discovery of novel ursolic acid derivatives as effective antimicrobial agents through a ROS-mediated apoptosis

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 12,   Pages 2101-2113 doi: 10.1007/s11705-023-2361-5

Abstract: In response to the reduction of food production and economic losses caused by plant bacterial diseases, it is necessary to develop new, efficient, and green pesticides. Natural products are rich and sustainable source for the development of new pesticides due to their low toxicity, easy degradation, and eco-friendliness. In this study, we prepared three series of ursolic acid derivatives and assessed their antibacterial ability. Most target compounds exhibited outstanding antibacterial activities. Among them, the relative optimal EC50 values of Xanthomonas oryzae pv. oryzae and Xanthomonas axonopodis pv. citri were 2.23 (A17) and 1.39 (A16) μg·mL–1, respectively. The antimicrobial mechanism showed that compound A17 induced an excessive accumulation and production of reactive oxygen species in bacteria and damaged the cell membrane integrity to kill bacteria. More interestingly, the addition of low concentrations of exogenous hydrogen peroxide enhanced the antibacterial efficacy of compound A17 against Xanthomonas oryzae pv. oryzae. These entertaining results suggested that compound A17 induced an apparent apoptotic behavior in the tested bacteria. Overall, we developed the promising antimicrobial agents that destroyed the redox system of phytopathogenic bacteria, further demonstrating the unprecedented potential of ursolic acid for agricultural applications.

Keywords： ursolic acid     antibacterial activities     reactive oxygen species     apoptosis    

HTML PDF Collect

Relationship between expression of hepatocyte grow factor and apoptosis of trophoblasts in hypertensive

OUYANG Shan, ZHANG Qinghua, QIAO Fuyuan

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 386-389 doi: 10.1007/s11684-007-0075-6

Abstract: hypertensive disorder complicating pregnancy (HDCP), and elucidate the possible relationship between HGF and apoptosisThese results indicate that HGF inhibits the apoptosis mediated by Fas, and the reduced expression ofHGF in HDCP may be responsible for the apoptosis of trophoblasts.

Keywords： pregnancy     concentration     possible relationship     responsible     hepatocyte    

HTML PDF Collect

Effect on proliferation and apoptosis of T24 cell lines via silencing DNMT1 with RNA interference

ZHANG Shilong, ZENG Fuqing, PENG Shibo, WANG Liang

Frontiers of Medicine 2008, Volume 2, Issue 4,   Pages 374-379 doi: 10.1007/s11684-008-0072-4

Abstract: Proliferation and apoptosis were assayed by MTT and flow cytometry with Annexin-V-FITC/PI staining.each time points ( < 0.01); 24, 48 and 72 hours after T24 cells were transfected by pshRNA-DNMT1, the apoptosissome extent, it also can inhibit the proliferation of bladder cancer cell and promote the cellular apoptosis
HTML PDF Collect

Effect of arsenic trioxide on proliferation and apoptosis of U266 cells and its relationship with the

ZHAN Rong, YU Qinghong, HUANG Haobo

Frontiers of Medicine 2008, Volume 2, Issue 4,   Pages 356-360 doi: 10.1007/s11684-008-0068-0

Abstract: The aim of this article is to explore the effect of arsenic trioxide (AsO) on the proliferation and apoptosisThe viability and apoptosis of U266 cells were observed by methylthiazolyl- tetrazolium (MTT) assay andmol/L AsO for 36 hours, dose-dependent apoptosis of U266 cells was observed.So we draw the conclusion that AsO could induce the apoptosis of U266 cells and inhibit their proliferation

Keywords： VEGF expression     expression variation     culture supernatant     labeling     concentration    

HTML PDF Collect

Absence of FHIT expression is associated with apoptosis inhibition in colorectal cancer

CAO Jie, LI Wanglin, XIA Jie, TANG Weibiao, WANG Hui, CHEN Xiwen, XIAO Huanqing, LI Yuyuan, CHEN Xiaoping, DU Hong, CHEN Shanming

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 147-156 doi: 10.1007/s11684-007-0028-0

Abstract: In our present study we tested the hypothesis that the decreased FHIT expression resulted in apoptosisinhibition associated with abnormal expression of apoptosis related proteins.In the first test, we assessed apoptosis status using a standard TUNEL (terminal deoxynucleotidyl transferase-mediatedIn the second experiment, the protein expression of the FHIT and other apoptosis related proteins (BaxBoth TUNEL and TMA experiments demonstrated significantly inhibited apoptosis by down-regulation of Bax
HTML PDF Collect

-132) significantly suppresses tumor growth in mouse model by inhibiting angiogenesis and promoting apoptosis

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 873-882 doi: 10.1007/s11684-022-0925-2

Abstract: Tumstatin is a tumor-specific angiogenesis inhibitor that suppresses the proliferation and induces the apoptosisVNP-Tum5 exhibited a higher efficacy in inhibiting the proliferation and inducing the necrosis and apoptosis

Keywords： Salmonella VNP20009     tumstatin     B16F10     melanoma     apoptosis     angiogenesis    

HTML PDF Collect

Effects of 3-aminobenzamide on poly (ADP-ribose) polymerase expression, apoptosis and cell cycle progression

DU Xiang, ZHAO Hongguang, GUO Wei, GONG Shouliang, WANG Wen

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 204-206 doi: 10.1007/s11684-008-0039-5

Abstract: The aim of this paper is to study the changes of apoptosis and cell cycle progression in HeLa cells afterIt indicates that 3-AB can rapidly inhibit PARP expression of HeLa cells, promote cell apoptosis and

Keywords： control     irradiation     apoptotic     progression     3-AB    

HTML PDF Collect

Inhibition of NF-kappa B can enhance Fas-mediated apoptosis in leukemia cell line HL-60

Li WANG, Shi ZHAO, Hong-Xiang WANG, Ping ZOU

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 323-328 doi: 10.1007/s11684-010-0026-5

Abstract: effects of nuclear factor-kappa B (NF-κB) inhibitor Bay 11-7082 on Fas/FasL system and Fas-mediated apoptosisThe mRNA and protein levels of Fas, FasL, and X-linked inhibitor of apoptosis protein (XIAP) were detectedcytometry (FCM); the level of sFasL was evaluated by enzyme-linked immunosorbent assay (ELISA); and apoptosisTherefore, we conclude that Bay 11-7082 can enhance Fas-mediated apoptosis in HL-60 cells by downregulating

Keywords： nuclear factor-kappa B     Fas/FasL system     HL-60     Bay 11-7082    

HTML PDF Collect

Non-genetic mechanisms of diabetic nephropathy

Qiuxia Han, Hanyu Zhu, Xiangmei Chen, Zhangsuo Liu

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 319-332 doi: 10.1007/s11684-017-0569-9

Abstract: pathogenesis of DN from the aspects of immune inflammation response, epithelial–mesenchymal transition, apoptosis

Keywords： diabetic nephropathy     immune inflammatory response     epithelial–mesenchymal transition     apoptosis     mitochondrial    

HTML PDF Collect

Effect of pirfenidone on renal tubulointerstitial fibrosis

Dixin LI MM , Hongbing ZENG MD , Chunyang JI MM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 316-322 doi: 10.1007/s11684-009-0045-2

Abstract: In this work, we employed a unilateral ureteral obstruction (UUO) rat model to investigate the apoptosishistology was studied by using periodic acid schiff reagent (PAS) and Masson trichromic stain (MASSON); apoptosisTIF, apoptosis of RTC, tubular expression of caspase-3 and the content of MDA were increased in the UUOshowed that PFD could ameliorate TIF in the UUO group, and the possible mechanism was by reducing the apoptosis

Keywords： pirfenidone     apoptosis     caspase 3     oxidative stress    

HTML PDF Collect

hydrophobic environment triggering reactive fluorescence probe to real-time monitor mitochondrial DNA damage

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 1,   Pages 92-102 doi: 10.1007/s11705-021-2063-9

Abstract: potentially effective detection tool for the real-time monitoring of mitochondrial DNA damage during cell apoptosisand initial assessment of cell apoptosis.

Keywords： reaction     mitochondrial DNA damage     in situ hydrophobic environment trigger     fluorescence probe     apoptosis    

HTML PDF Collect

Combined gemcitabine and CHK1 inhibitor treatment induces apoptosis resistance in cancer stem cell-like

Douglas D. Fang, Joan Cao, Jitesh P. Jani, Konstantinos Tsaparikos, Alessandra Blasina, Jill Kornmann, Maruja E. Lira, Jianying Wang, Zuzana Jirout, Justin Bingham, Zhou Zhu, Yin Gu, Gerrit Los, Zdenek Hostomsky, Todd VanArsdale

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 462-476 doi: 10.1007/s11684-013-0270-6

Abstract: However, the CSC-like cells exhibited resistance to gemcitabine-induced apoptosis.

Keywords： drug resistance     cancer stem cell     checkpoint kinase 1 (CHK1)     PF-00477736     lung cancer     tumorigenicity    

HTML PDF Collect

Tanshinone IIA Suppresses Non-Small Cell Lung Cancer Through Beclin-1-Mediated Autophagic Apoptosis Article

Shasha Bai, Sainan Cui, Wenhao Wen, Elaine Lai-Han Leung, Jing Bai, Huiyuan Lin, Yongfei Cui, Lei Yang, Zhongqiu Liu, Yuan Zheng, Rong Zhang

Engineering 2022, Volume 19, Issue 12,   Pages 128-138 doi: 10.1016/j.eng.2021.07.014

Abstract: that Tan IIA could inhibit lung cancer in vitro and in vivo by inducing autophagic apoptosisdownregulation of autophagic gene 5 (ATG5) further confirmed that Tan IIA induced autophagic apoptosis-1 gene (BECN1) overexpression and silence attenuated the effects of Tan IIA, suggesting autophagic apoptosis

Keywords： Tan IIA     Autophagy     Apoptosis     Beclin-1    

HTML PDF Collect

Human menstrual blood-derived stem cells alleviate autoimmune hepatitis via JNK/MAPK signaling pathway and

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 534-548 doi: 10.1007/s11684-022-0953-y

Abstract: The results of phosphoproteomic analysis and RNA-seq revealed that MenSCs improved AIH, mainly by apoptosisApoptosis analysis demonstrated that the protein expression of cleaved caspase 3 was increased by ConAn AML12 co-culture system and JNK inhibitor (SP600125) were used to verify the JNK/MAPK and apoptosis

Keywords： autoimmune hepatitis (AIH)     concanavalin A (Con A)     human menstrual blood-derived stem cells (MenSCs)     apoptosis    

HTML PDF Collect

Title Author Date Type Operation

Targeting apoptosis to manage acquired resistance to third generation EGFR inhibitors

Journal Article

Discovery of novel ursolic acid derivatives as effective antimicrobial agents through a ROS-mediated apoptosis

Journal Article

Relationship between expression of hepatocyte grow factor and apoptosis of trophoblasts in hypertensive

OUYANG Shan, ZHANG Qinghua, QIAO Fuyuan

Journal Article

Effect on proliferation and apoptosis of T24 cell lines via silencing DNMT1 with RNA interference

ZHANG Shilong, ZENG Fuqing, PENG Shibo, WANG Liang

Journal Article

Effect of arsenic trioxide on proliferation and apoptosis of U266 cells and its relationship with the

ZHAN Rong, YU Qinghong, HUANG Haobo

Journal Article

Absence of FHIT expression is associated with apoptosis inhibition in colorectal cancer

CAO Jie, LI Wanglin, XIA Jie, TANG Weibiao, WANG Hui, CHEN Xiwen, XIAO Huanqing, LI Yuyuan, CHEN Xiaoping, DU Hong, CHEN Shanming

Journal Article

-132) significantly suppresses tumor growth in mouse model by inhibiting angiogenesis and promoting apoptosis

Journal Article

Effects of 3-aminobenzamide on poly (ADP-ribose) polymerase expression, apoptosis and cell cycle progression

DU Xiang, ZHAO Hongguang, GUO Wei, GONG Shouliang, WANG Wen

Journal Article

Inhibition of NF-kappa B can enhance Fas-mediated apoptosis in leukemia cell line HL-60

Li WANG, Shi ZHAO, Hong-Xiang WANG, Ping ZOU

Journal Article

Non-genetic mechanisms of diabetic nephropathy

Qiuxia Han, Hanyu Zhu, Xiangmei Chen, Zhangsuo Liu

Journal Article

Effect of pirfenidone on renal tubulointerstitial fibrosis

Dixin LI MM , Hongbing ZENG MD , Chunyang JI MM ,

Journal Article

hydrophobic environment triggering reactive fluorescence probe to real-time monitor mitochondrial DNA damage

Journal Article

Combined gemcitabine and CHK1 inhibitor treatment induces apoptosis resistance in cancer stem cell-like

Douglas D. Fang, Joan Cao, Jitesh P. Jani, Konstantinos Tsaparikos, Alessandra Blasina, Jill Kornmann, Maruja E. Lira, Jianying Wang, Zuzana Jirout, Justin Bingham, Zhou Zhu, Yin Gu, Gerrit Los, Zdenek Hostomsky, Todd VanArsdale

Journal Article

Tanshinone IIA Suppresses Non-Small Cell Lung Cancer Through Beclin-1-Mediated Autophagic Apoptosis

Shasha Bai, Sainan Cui, Wenhao Wen, Elaine Lai-Han Leung, Jing Bai, Huiyuan Lin, Yongfei Cui, Lei Yang, Zhongqiu Liu, Yuan Zheng, Rong Zhang

Journal Article

Human menstrual blood-derived stem cells alleviate autoimmune hepatitis via JNK/MAPK signaling pathway and

Journal Article