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Genome-wide association studies: inherent limitations and future challenges

Yan Du, Jiaxin Xie, Wenjun Chang, Yifang Han, Guangwen Cao

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 444-450 doi: 10.1007/s11684-012-0225-3

Abstract:

Genome-wide association studies (GWAS) have achieved great success in identifying genetic variants

Keywords： genome-wide association studies (GWAS)     genetic variant     cancer     limitation     challenge    

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Advancement in genetic variants conferring obesity susceptibility from genome-wide association studies

Tao Wang,Weiping Jia,Cheng Hu

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 146-161 doi: 10.1007/s11684-014-0373-8

Abstract: The advent of genome-wide association studies (GWAS) has hastened the progress of polygenic obesity research

Keywords： obesity     genetics     genome-wide association studies     body mass index     fat mass- and obesity-associated gene    

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Survey of the Algorithms on Association Rule Mining

Bi Jianxin,Zhang Qishan

Strategic Study of CAE 2005, Volume 7, Issue 4,   Pages 88-94

Abstract:

In this paper the principle of the algorithms on association rule mining is introduced firstly, andresearches of the algorithms on association rule mining are summarized in turn according to variableAt last, some future directions on association rule generation are viewed.

Keywords： data mining     association rule     algorithms     survey    

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Obesity and overweight prevalence and its association with undiagnosed hypertension in Shanghai population

Xinjian Li, Jiying Xu, Haihong Yao, Yanfei Guo, Minna Chen, Wei Lu

Frontiers of Medicine 2012, Volume 6, Issue 3,   Pages 322-328 doi: 10.1007/s11684-012-0204-8

Abstract: determine the prevalence of overweight and obese subjects in the Shanghai population of China and its associationMultiple logistic regression analyses were used to assess the association of overweight or obesity withThese data suggest that overweight and obesity prevalence and their association with undiagnosed hypertension

Keywords： overweight     obesity     undiagnosed hypertension     prevalence     association    

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Genome-wide association study of the backfat thickness trait in two pig populations

Dandan ZHU,Xiaolei LIU,Rothschild MAX,Zhiwu ZHANG,Shuhong ZHAO,Bin FAN

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 2,   Pages 91-95 doi: 10.15302/J-FASE-2014005

Abstract: rib backfat thickness trait were identified in two independent pig populations, using a genome-wide association

Keywords： backfat thickness     SNP chip     genome-wide association study     compressed mixed linear model     pig    

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How to judge the association of postmenopausal hormone therapy and the risk of breast cancer

Ling XU

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 290-293 doi: 10.1007/s11684-010-0093-7

Abstract: The relevance of postmenopausal hormone therapy (HT) for breast cancer risk has been long debated, although it is one of the most important barriers for women to accept HT. Various opinions have been reported from recent randomized clinical trials and epidemiological studies. These unanswered questions include: whether HT has a positive impact on breast cancer; whether risks of therapy with unopposed estrogen and combined estrogen-progestin are different; and whether different types and routes of estrogen and progestogens, as well as the duration and cessation of HT use, have different impacts on this disorder. Recently, there has been some good news such as the following: the currently available data do not provide sufficient evidence to prove a causal relationship between postmenopausal HT and breast cancer; breast cancer in postmenopausal women using HT usually has better prognosis than that of nonusers. In conclusion, HT is still the most effective method of relieving climacteric symptoms for many postmenopausal women. However, a possible risk of breast cancer associated with long-term HT usage should not be ignored. With respect to prevention of breast cancer, regular evaluation of individual breast cancer susceptibility and close follow-up through mammography and/or breast sonography are necessary strategies for the safety of HT use.

Keywords： breast cancer     postmenopausal hormone therapy     unopposed estrogen therapy     combined estrogen-progestin therapy    

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Abiotic association of phthalic acid esters with humic acid of a sludge landfill

Xiaoli CHAI, Yongxia HAO, Xin ZHAO, Guixiang LIU, Ying ZHU, Rong JI, Jun WU, Huanhuan TONG, Youcai ZHAO

Frontiers of Environmental Science & Engineering 2012, Volume 6, Issue 6,   Pages 778-783 doi: 10.1007/s11783-012-0434-7

Abstract: The abiotic association between phthalic acid esters (PAEs) and humic substances (HS) in sludge landfillAn equilibrium dialysis combined with C-labeling was used to study the abiotic association of two abundantThe results indicated that the association strength of PAEs with HA depended on both the properties ofThe values of the association were strongly dependent on solution pH, and decreased dramatically asThe interactive hydrogen-bonds between the HA and the PAEs molecules may also be involved in the association

Keywords： abiotic association     phthalic acid esters (PAEs)     humic acid     sludge     landfill    

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Distribution of antibiotic resistance genes and their association with bacteria and viruses in decentralized

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 3, doi: 10.1007/s11783-021-1469-4

Abstract:

• Distribution of ARGs in decentralized sewage facilities were investigated.

Keywords： Decentralized sewage treatment facilities     Antibiotic resistance genes     Virus     Metagenomics     Network analysis    

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A post-GWAS replication study confirming the association of

Shaohua YANG,Chao QI,Yan XIE,Xiaogang CUI,Yahui GAO,Jianping JIANG,Li JIANG,Shengli ZHANG,Qin ZHANG,Dongxiao SUN

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 4,   Pages 321-330 doi: 10.15302/J-FASE-2014037

Abstract: Genome-wide association studies with an Illumina Bovine50K chip have detected 105 SNPs associated withof nine of these identified SNPs were successfully genotyped and analyzed by mass spectrometry for associationThese findings, therefore, provide strong evidence for association of variants with milk yield and

Keywords： annotation     Chinese Holstein     milk production traits     C14H8orf33 gene     single nucleotide polymorphisms     association    

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Genome-wide association analysis reveals genetic loci and candidate genes associated with intramuscular

Xingwang WANG, Rongrong DING, Jianping QUAN, Linxue YANG, Ming YANG, Enqin ZHENG, Dewu LIU, Gengyuan CAI, Zhenfang WU, Jie YANG

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3,   Pages 335-341 doi: 10.15302/J-FASE-2017152

Abstract: Genome-wide association study is a powerful tool to detect genomic regions associated with phenotypic

Keywords： Duroc pigs     genome-wide association analysis     intramuscular fat    

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Joint user association and resource partition for downlink-uplink decoupling inmulti-tierHetNets Article

Zhi-yong FENG, Ze-bing FENG, T. Aaron GULLIVER

Frontiers of Information Technology & Electronic Engineering 2017, Volume 18, Issue 6,   Pages 817-829 doi: 10.1631/FITEE.1700031

Abstract: In this paper, a joint user association and resource partition framework for downlink-uplink decouplingDifferent from the traditional association rules such as maximal received power and range extension,a coalition game based scheme is proposed for the optimal user association with DUDe.Moreover, the DL and UL optimal bandwidth partition for BSs is derived based on user association consideringdemonstrate the effectiveness of the proposed scheme, which enhances the sum rate compared with other user association

Keywords： Downlink-uplink decoupling     User association     Resource partition     Heterogeneous cellular network     Coalition    

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U-shaped association between telomere length and esophageal squamous cell carcinoma risk: a case-control

Jiangbo Du,Wenjie Xue,Yong Ji,Xun Zhu,Yayun Gu,Meng Zhu,Cheng Wang,Yong Gao,Juncheng Dai,Hongxia Ma,Yue Jiang,Jiaping Chen,Zhibin Hu,Guangfu Jin,Hongbing Shen

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 478-486 doi: 10.1007/s11684-015-0420-0

Abstract: length-related single nucleotide polymorphisms (TL-SNPs) in Caucasians have been reported in genome-wide associationMore interestingly, an evident nonlinear U-shaped association was observed between RTL and ESCC risk

Keywords： esophageal squamous cell carcinoma     telomere length     genetic variants     susceptibility     genome-wide association    

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J-shaped association between dietary zinc intake and new-onset hypertension: a nationwide cohort study

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 156-164 doi: 10.1007/s11684-022-0932-3

Abstract: Overall, the association between dietary zinc intake and new-onset hypertension followed a J-shape (association between dietary zinc intake and new-onset hypertension

Keywords： dietary zinc intake     new-onset hypertension     general population     CHNS    

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Solution properties and self-association of multi-blocks like copolymer P(AM/AA) prepared by template

ZHANG Yuxi, WU Feipeng, LI Miaozhen, WANG Erjian

Frontiers of Chemical Science and Engineering 2007, Volume 1, Issue 1,   Pages 68-71 doi: 10.1007/s11705-007-0014-8

Abstract: The association and properties of multi-block like copolymers (TP) of acrylamide (AM) and acrylic acid

Keywords： aqueous solution     homopolyacrylic     copolymer solution     significant structure     presence    

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Protein aggregation in association with delayed neuronal death in rat model of brain ischemia

GE Pengfei, FU Shuanglin, LI Wenchen, WANG Chonghao, ZHOU Chuibing, LUO Yinan, LUO Tianfei

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 70-74 doi: 10.1007/s11684-008-0013-2

Abstract: To investigate the relationship between protein aggregation and delayed neuronal death, we adopted rat models of 20 min ischemia. Brain ischemia was produced using the 2-vessel occlusion (2VO) model in rats Light microscopy, transmission electronic microscopy and Western blot analysis were performed for morphological analysis of neurons, and protein detection. The results showed delayed neuronal death took place at 72 h after ischemia-reperfusion, protein aggregates formed at 4 h after reperfusion and reached the peak at 24 h after reperfusion, and Western blot analysis was consistent with transmission electronic microscopy. We conclude that protein aggregation is one of the important factors leading to delayed neuronal death.
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Title Author Date Type Operation

Genome-wide association studies: inherent limitations and future challenges

Yan Du, Jiaxin Xie, Wenjun Chang, Yifang Han, Guangwen Cao

Journal Article

Advancement in genetic variants conferring obesity susceptibility from genome-wide association studies

Tao Wang,Weiping Jia,Cheng Hu

Journal Article

Survey of the Algorithms on Association Rule Mining

Bi Jianxin,Zhang Qishan

Journal Article

Obesity and overweight prevalence and its association with undiagnosed hypertension in Shanghai population

Xinjian Li, Jiying Xu, Haihong Yao, Yanfei Guo, Minna Chen, Wei Lu

Journal Article

Genome-wide association study of the backfat thickness trait in two pig populations

Dandan ZHU,Xiaolei LIU,Rothschild MAX,Zhiwu ZHANG,Shuhong ZHAO,Bin FAN

Journal Article

How to judge the association of postmenopausal hormone therapy and the risk of breast cancer

Ling XU

Journal Article

Abiotic association of phthalic acid esters with humic acid of a sludge landfill

Xiaoli CHAI, Yongxia HAO, Xin ZHAO, Guixiang LIU, Ying ZHU, Rong JI, Jun WU, Huanhuan TONG, Youcai ZHAO

Journal Article

Distribution of antibiotic resistance genes and their association with bacteria and viruses in decentralized

Journal Article

A post-GWAS replication study confirming the association of

Shaohua YANG,Chao QI,Yan XIE,Xiaogang CUI,Yahui GAO,Jianping JIANG,Li JIANG,Shengli ZHANG,Qin ZHANG,Dongxiao SUN

Journal Article

Genome-wide association analysis reveals genetic loci and candidate genes associated with intramuscular

Xingwang WANG, Rongrong DING, Jianping QUAN, Linxue YANG, Ming YANG, Enqin ZHENG, Dewu LIU, Gengyuan CAI, Zhenfang WU, Jie YANG

Journal Article

Joint user association and resource partition for downlink-uplink decoupling inmulti-tierHetNets

Zhi-yong FENG, Ze-bing FENG, T. Aaron GULLIVER

Journal Article

U-shaped association between telomere length and esophageal squamous cell carcinoma risk: a case-control

Jiangbo Du,Wenjie Xue,Yong Ji,Xun Zhu,Yayun Gu,Meng Zhu,Cheng Wang,Yong Gao,Juncheng Dai,Hongxia Ma,Yue Jiang,Jiaping Chen,Zhibin Hu,Guangfu Jin,Hongbing Shen

Journal Article

J-shaped association between dietary zinc intake and new-onset hypertension: a nationwide cohort study

Journal Article

Solution properties and self-association of multi-blocks like copolymer P(AM/AA) prepared by template

ZHANG Yuxi, WU Feipeng, LI Miaozhen, WANG Erjian

Journal Article

Protein aggregation in association with delayed neuronal death in rat model of brain ischemia

GE Pengfei, FU Shuanglin, LI Wenchen, WANG Chonghao, ZHOU Chuibing, LUO Yinan, LUO Tianfei

Journal Article