Resource Type

Journal Article 2

Year

2017 1

2012 1

Keywords

astaxanthin 2

Saccharomyces cerevisiae 1

β-carotene hydroxylase 1

β-carotene ketolase 1

evolutionary engineering 1

strain improvement 1

synthetic biology 1

open ︾

Search scope:

排序： Display mode:

Evolutionary engineering of

Jixian GONG, Nan DUAN, Xueming ZHAO

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 2,   Pages 174-178 doi: 10.1007/s11705-012-1276-3

Abstract: Astaxanthin has been widely used in cosmetics, pharmaceutical and health care food due to its capabilityStrain improvement of , one of the main sources for natural astaxanthin, is of commercial interest forastaxanthin production.The evolved strains produced up to 48.2% more astaxanthin than the initial strain.

Keywords： evolutionary engineering     astaxanthin     strain improvement    

HTML PDF Collect

Engineering of

Ruizhao Wang,Xiaoli Gu,Mingdong Yao,Caihui Pan,Hong Liu,Wenhai Xiao,Ying Wang,Yingjin Yuan

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 1,   Pages 89-99 doi: 10.1007/s11705-017-1628-0

Abstract: The conversion of -carotene to astaxanthin is a complex pathway network, in which two steps of hydroxylationHere, astaxanthin biosynthesis pathway was constructed in by introducing heterologous CrtZ and CrtWProtein phylogenetic analysis shows that the shorter evolutionary distance of CrtW is, the higher astaxanthinFurther, when the promoter of in strain SyBE_Sc118060 was replaced from FBA1p to TEF1p, the astaxanthinin a 5-L bioreactor reached to 81.0 mg/L, which was the highest astaxanthin titer reported in yeast.

Keywords： synthetic biology     astaxanthin     β-carotene hydroxylase     β-carotene ketolase     Saccharomyces    

HTML PDF Collect

Title Author Date Type Operation

Evolutionary engineering of

Jixian GONG, Nan DUAN, Xueming ZHAO

Journal Article

Engineering of

Ruizhao Wang,Xiaoli Gu,Mingdong Yao,Caihui Pan,Hong Liu,Wenhai Xiao,Ying Wang,Yingjin Yuan

Journal Article