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Coronavirus disease 2019 (COVID-19): a clinical update

Min Zhou, Xinxin Zhang, Jieming Qu

Frontiers of Medicine 2020, Volume 14, Issue 2,   Pages 126-135 doi: 10.1007/s11684-020-0767-8

Abstract: promising antivirals, convalescent plasma transfusion, and tocilizumab needs to be investigated by ongoing clinical

Keywords： coronavirus disease 2019     epidemiology     pathology     radiology     clinical characteristics     treatment    

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Translating evidence into policy in China: opportunities and challenges

Jiyao Wang, Xuejuan Jin

Frontiers of Medicine 2011, Volume 5, Issue 3,   Pages 315-320 doi: 10.1007/s11684-011-0146-6

Abstract: In the past two decades, the Chinese Clinical Epidemiology Network has been promoting evidence-based

Keywords： clinical epidemiology     evidence-based decision making     policy    

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Venous thromboembolism in children with acute lymphoblastic leukemia in China: a report from the Chinese Children’s Cancer Group-ALL-2015

Frontiers of Medicine doi: 10.1007/s11684-022-0958-6

Abstract: The Chinese Children’s Cancer Group-ALL-2015 protocol was carried out in China, and epidemiology, clinicalWe collected data on VTE in a multi-institutional clinical study of 7640 patients with ALL diagnosed

Keywords： acute lymphoblastic leukemia     child     venous thromboembolism     epidemiology     clinical characteristic     risk    

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Recent transmission of Mycobacterium tuberculosis in China: the implication of molecular epidemiology

Chongguang Yang, Qian Gao

Frontiers of Medicine 2018, Volume 12, Issue 1,   Pages 76-83 doi: 10.1007/s11684-017-0609-5

Abstract: Evidence from molecular epidemiology studies has delineated the recent transmission of ( ) strains inWe reviewed the implementations of molecular epidemiology of TB in China, the estimated disease burden

Keywords： tuberculosis     recent transmission     molecular epidemiology     China    

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Chronic hepatitis B virus infection: epidemiology, prevention, and treatment in China

Rui Yu,Rong Fan,Jinlin Hou

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 135-144 doi: 10.1007/s11684-014-0331-5

Abstract: The universal vaccination program since 1992 has changed the epidemiology of hepatitis B virus infection

Keywords： chronic hepatitis B     epidemiology     prevention     treatment    

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The epidemiology of norovirus gastroenteritis in China: disease burden and distribution of genotypes

Honglu Zhou, Songmei Wang, Lorenz von Seidlein, Xuanyi Wang

Frontiers of Medicine 2020, Volume 14, Issue 1,   Pages 1-7 doi: 10.1007/s11684-019-0733-5

Abstract: needed, since two vaccine candidates based on virus-like particles (VLPs) are currently moving into clinical

Keywords： molecular epidemiology     norovirus     disease burden     genotype     China    

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Avian influenza A: an avian influenza virus from low pathogenic to highly pathogenic

William J. Liu, Haixia Xiao, Lianpan Dai, Di Liu, Jianjun Chen, Xiaopeng Qi, Yuhai Bi, Yi Shi, George F. Gao, Yingxia Liu

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 507-527 doi: 10.1007/s11684-020-0814-5

Abstract: It was summarized and discussed from the perspectives of molecular epidemiology, clinical features, virulence

Keywords： H7N9     HPAIV     epidemiology     clinical features     pathogenesis     hemagglutinin     immunity     vaccine    

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Epidemiology of fungal infections in China

Min Chen, Yuan Xu, Nan Hong, Yali Yang, Wenzhi Lei, Lin Du, Jingjun Zhao, Xia Lei, Lin Xiong, Langqi Cai, Hui Xu, Weihua Pan, Wanqing Liao

Frontiers of Medicine 2018, Volume 12, Issue 1,   Pages 58-75 doi: 10.1007/s11684-017-0601-0

Abstract:

With the increasing number of immunocompromised hosts, the epidemiological characteristics of fungal infections have undergone enormous changes worldwide, including in China. In this paper, we reviewed the existing data on mycosis across China to summarize available epidemiological profiles. We found that the general incidence of superficial fungal infections in China has been stable, but the incidence of tinea capitis has decreased and the transmission route has changed. By contrast, the overall incidence of invasive fungal infections has continued to rise. The occurrence of candidemia caused by species other than and including some uncommon species has increased recently in China. Infections caused by have also propagated in recent years, particularly with the emergence of azole-resistant . An increasing trend of cryptococcosis has been noted in China, with var. ST 5 genotype isolates as the predominant pathogen. Retrospective studies have suggested that the epidemiological characteristics of pneumonia in China may be similar to those in other developing countries. Endemic fungal infections, such as sporotrichosis in Northeastern China, must arouse research, diagnostic, and treatment vigilance. Currently, the epidemiological data on mycosis in China are variable and fragmentary. Thus, a nationwide epidemiological research on fungal infections in China is an important need for improving the country’s health.

Keywords： fungi     infection     epidemiology     China    

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Molecular Epidemiology of Klebsiella pneumoniae from Clinical Bovine Mastitis in Northern Area Article

Shikai Song, Wenjuan He, Dawei Yang, Manar Benmouffok, Yao Wang, Jiyun Li, Chengtao Sun, Xiangbin Song, Shizhen Ma, Chang Cai, Shuangyang Ding, Congming Wu, Zhangqi Shen, Yang Wang,

Engineering 2022, Volume 10, Issue 3,   Pages 146-154 doi: 10.1016/j.eng.2021.01.015

Abstract: Herein, we investigated the prevalence of K. pneumoniae in 6301 clinical mastitis (CM) milkLike human clinical K. pneumoniae, all CM K. pneumoniae isolates belonged to one of

Keywords： Clinical mastitis     Klebsiella pneumonia     Molecular characteristics     Population structure     Antimicrobial    

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Genomic Epidemiology of ST34 Monophasic Salmonella enterica Serovar Typhimurium from Clinical Patients Article

Yujiao Mu, Ruichao Li, Pengcheng Du, Pei Zhang, Yan Li, Shenghui Cui, Séamus Fanning, Li Bai

Engineering 2022, Volume 15, Issue 8,   Pages 34-44 doi: 10.1016/j.eng.2022.05.006

Abstract: To date, the epidemiology and genomic characterization of this pathogen in China have not been well described

Keywords： Salmonella Typhimurium monophasic variant     ST34     Prevalence     Phylogenetic analysis     Chinese lineages    

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Ontological reconstruction of the clinical terminology of traditional Chinese medicine

Li Ma,Baoyan Liu,Qi Xie,Shusong Mao,Zhiwei Cui

Frontiers of Medicine 2014, Volume 8, Issue 3,   Pages 358-361 doi: 10.1007/s11684-014-0348-9

Abstract:

This study proposes the ontological reconstruction of the current clinical terminology of traditionalof preliminary work related to the said reconstruction, including the ontology-based analysis of TCM clinicalWe conclude that the ontological reconstruction of TCM clinical terminology provides a proper translation

Keywords： ontology     traditional Chinese medicine     clinical terminology    

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Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment

Tianhua Xu, Zitong Sheng, Li Yao

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 340-348 doi: 10.1007/s11684-017-0570-3

Abstract: A slow increase of subnephrotic proteinuria (<3.5 g/d) is the most common clinical manifestation of

Keywords： obesity-related glomerulopathy     pathogenesis     pathologic     clinical characteristics    

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Molecular epidemiology of Cryptococcus neoformans species complex isolates from HIV-positive and HIV-negative

Min CHEN MM, Wei-Hua PAN MD, Wan-Qing LIAO MM, Xiao-Ran LI BS, Bi-Wei FENG BS, Zhe-Xue QUAN PhD, Shao-Xi WU MD, Xiao-Ping TANG MD, Zhi-Rong YAO MD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 117-126 doi: 10.1007/s11684-010-0011-z

Abstract: This study investigated the molecular types of the species complex isolates and their clinical manifestationsIn HIV-positive patients, clinical isolates were grouped into molecular types VNI (75%, 15/20), VNIIIn HIV-negative patients, the majority of the clinical isolates were grouped into molecular types VNIAs for the clinical manifestations of the molecular types among the patients, the average cerebrospinal

Keywords： Cryptococcus neoformans     Cryptococcus gattii     cryptococcosis     molecular epidemiology     molecular type     mating    

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Bone metastasis of hepatocellular carcinoma: facts and hopes from clinical and translational perspectives

Frontiers of Medicine   Pages 551-573 doi: 10.1007/s11684-022-0928-z

Abstract: Patients with hepatocellular carcinoma (HCC) and bone metastasis (BM) suffer from greatly reduced life quality and a dismal prognosis. However, BM in HCC has long been overlooked possibly due to its relatively low prevalence in previous decades. To date, no consensus or guidelines have been reached or formulated for the prevention and management of HCC BM. Our narrative review manifests the increasing incidence of HCC BM to sound the alarm for additional attention. The risk factors, diagnosis, prognosis, and therapeutic approaches of HCC BM are detailed to provide a panoramic view of this disease to clinicians and specialists. We further delineate an informative cancer bone metastatic cascade based on evidence from recent studies and point out the main factors responsible for the tumor-associated disruption of bone homeostasis and the formation of skeletal cancer lesions. We also present the advances in the pathological and molecular mechanisms of HCC BM to shed light on translational opportunities. Dilemmas and challenges in the treatment and investigation of HCC BM are outlined and discussed to encourage further endeavors in the exploration of underlying pathogenic and molecular mechanisms, as well as the development of novel effective therapies for HCC patients with BM.

Keywords： HCC     bone     osteotropism     clinical     basic researches     advances    

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Neosporosis: An Overview of Its Molecular Epidemiology and Pathogenesis Review

Asis Khan, Jahangheer S. Shaik, Patricia Sikorski, Jitender P. Dubey, Michael E. Grigg

Engineering 2020, Volume 6, Issue 1,   Pages 10-19 doi: 10.1016/j.eng.2019.02.010

Abstract: Although molecular epidemiology studies are in their infancy, the 18S rRNA and ITS1 regions within theThe aim of this review is to outline our current understanding of the molecular epidemiology and genomics

Keywords： Neosporosis     Molecular epidemiology     Population genetics     Genomics     Host response     Vaccine    

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Title Author Date Type Operation

Coronavirus disease 2019 (COVID-19): a clinical update

Min Zhou, Xinxin Zhang, Jieming Qu

Journal Article

Translating evidence into policy in China: opportunities and challenges

Jiyao Wang, Xuejuan Jin

Journal Article

Venous thromboembolism in children with acute lymphoblastic leukemia in China: a report from the Chinese Children’s Cancer Group-ALL-2015

Journal Article

Recent transmission of Mycobacterium tuberculosis in China: the implication of molecular epidemiology

Chongguang Yang, Qian Gao

Journal Article

Chronic hepatitis B virus infection: epidemiology, prevention, and treatment in China

Rui Yu,Rong Fan,Jinlin Hou

Journal Article

The epidemiology of norovirus gastroenteritis in China: disease burden and distribution of genotypes

Honglu Zhou, Songmei Wang, Lorenz von Seidlein, Xuanyi Wang

Journal Article

Avian influenza A: an avian influenza virus from low pathogenic to highly pathogenic

William J. Liu, Haixia Xiao, Lianpan Dai, Di Liu, Jianjun Chen, Xiaopeng Qi, Yuhai Bi, Yi Shi, George F. Gao, Yingxia Liu

Journal Article

Epidemiology of fungal infections in China

Min Chen, Yuan Xu, Nan Hong, Yali Yang, Wenzhi Lei, Lin Du, Jingjun Zhao, Xia Lei, Lin Xiong, Langqi Cai, Hui Xu, Weihua Pan, Wanqing Liao

Journal Article

Molecular Epidemiology of Klebsiella pneumoniae from Clinical Bovine Mastitis in Northern Area

Shikai Song, Wenjuan He, Dawei Yang, Manar Benmouffok, Yao Wang, Jiyun Li, Chengtao Sun, Xiangbin Song, Shizhen Ma, Chang Cai, Shuangyang Ding, Congming Wu, Zhangqi Shen, Yang Wang,

Journal Article

Genomic Epidemiology of ST34 Monophasic Salmonella enterica Serovar Typhimurium from Clinical Patients

Yujiao Mu, Ruichao Li, Pengcheng Du, Pei Zhang, Yan Li, Shenghui Cui, Séamus Fanning, Li Bai

Journal Article

Ontological reconstruction of the clinical terminology of traditional Chinese medicine

Li Ma,Baoyan Liu,Qi Xie,Shusong Mao,Zhiwei Cui

Journal Article

Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment

Tianhua Xu, Zitong Sheng, Li Yao

Journal Article

Molecular epidemiology of Cryptococcus neoformans species complex isolates from HIV-positive and HIV-negative

Min CHEN MM, Wei-Hua PAN MD, Wan-Qing LIAO MM, Xiao-Ran LI BS, Bi-Wei FENG BS, Zhe-Xue QUAN PhD, Shao-Xi WU MD, Xiao-Ping TANG MD, Zhi-Rong YAO MD,

Journal Article

Bone metastasis of hepatocellular carcinoma: facts and hopes from clinical and translational perspectives

Journal Article

Neosporosis: An Overview of Its Molecular Epidemiology and Pathogenesis

Asis Khan, Jahangheer S. Shaik, Patricia Sikorski, Jitender P. Dubey, Michael E. Grigg

Journal Article