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Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes

Jianping Ye

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 139-145 doi: 10.1007/s11684-015-0377-z

Abstract: In summary, evidence from human and rodents supports that the pro-inflammatory cytokine IL-15 may enhance

Keywords： inflammation     obesity     cytokine     energy expenditure     insulin resistance    

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Cytokine storm and translating IL-6 biology into effective treatments for COVID-19

Frontiers of Medicine doi: 10.1007/s11684-023-1044-4

Abstract: The primary etiology may be attributed to cytokine storm, which is triggered by the excessive releaseThus, we review the history of cytokine storm and the process of targeting IL-6 signaling to elucidate

Keywords： SARS-CoV-2     COVID-19     cytokine storm     interleukin-6     tocilizumab    

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Inflammation and liver tumorigenesis

Beicheng Sun, Michael Karin

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 242-254 doi: 10.1007/s11684-013-0256-4

Abstract:

Inflammation has been considered as one of the hallmarks of cancer, and chronic hepatitis is a major cause of liver cancer. This review will focus on the pathogenic role of inflammation in hepatocarcinogenesis and will discuss recent advances in understanding the chronic hepatitis-liver cancer link based on hot spots in liver cancer research, including cellular interaction, cytokines, microRNA and stem cells. All of these mechanisms should be taken into consideration because they are crucial for the development of more efficacious therapeutic strategies for preventing and treating human chronic hepatitis and hepatocellular carcinoma.

Keywords： hepatocellular carcinoma     hepatitis     cytokine     stem cell     miRNA    

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High-affinity T cell receptors redirect cytokine-activated T cells (CAT) to kill cancer cells

Synat Kang, Yanyan Li, Yifeng Bao, Yi Li

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 69-82 doi: 10.1007/s11684-018-0677-1

Abstract:

Cytokine-activated T cells (CATs) can be easily expanded and are widely applied to cancer immunotherapy

Keywords： cytokine-activated T cells     high-affinity T cell receptor     cancer immunotherapy     TCR-CAT    

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Molecular characterization of two suppressor of cytokine signaling 1 genes (

Xue XU,Jiannan ZHANG,Juan LI,Yajun WANG

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 1,   Pages 73-83 doi: 10.15302/J-FASE-2015044

Abstract: Suppressor of cytokine signaling 1 (SOCS1) protein can inhibit the signal transduction triggered by someTaken together, these data suggest that both cSOCS1a and cSOCS1b may function as negative regulators of cytokine

Keywords： chicken     SOCS1a     SOCS1b     growth hormone     prolactin    

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Management of cytokine release syndrome related to CAR-T cell therapy

Hongli Chen, Fangxia Wang, Pengyu Zhang, Yilin Zhang, Yinxia Chen, Xiaohu Fan, Xingmei Cao, Jie Liu, Yun Yang, Baiyan Wang, Bo Lei, Liufang Gu, Ju Bai, Lili Wei, Ruili Zhang, Qiuchuan Zhuang, Wanggang Zhang, Wanhong Zhao, Aili He

Frontiers of Medicine 2019, Volume 13, Issue 5,   Pages 610-617 doi: 10.1007/s11684-019-0714-8

Abstract: Cytokine release syndrome (CRS) is one of the most clinically important and potentially life-threatening

Keywords： chimeric antigen receptor T cell     cytokine release syndrome     tocilizumab    

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Phase I study of CBM.CD19 chimeric antigen receptor T cell in the treatment of refractory diffuse large B-cell lymphoma in Chinese patients

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 285-294 doi: 10.1007/s11684-021-0843-8

Abstract: The incidence of cytokine release syndrome in all grades and grade≥3 was 90% and 0, respectively, which

Keywords： CAR-T cell therapy     refractory diffuse large B-cell lymphoma     cytokine release syndrome     dose-limiting    

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The relationship between progesterone and Th-related cytokines in plasma during early pregnancy in cows

Lei CHENG,Youdong XIN,Xiaohua LIU,Xiuzhong HU,Min XIANG,Dingfa WANG,Shuhong ZHAO

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 2,   Pages 147-152 doi: 10.15302/J-FASE-2016099

Abstract: In cows, progesterone (P4) is essential for the maintenance of pregnancy and successful embryo development is dependent on the maternal immunomodulation of Th-related cytokines. However, investigation of the relationship between P4 and Th immunity in cattle remains incomplete. Therefore, we evaluated plasma P4 concentrations and expressions of three Th-related cytokines, interleukins IL-1β, IL-4 and IL-6, in 15 pregnant and 11 non-pregnant cows 0, 14, 18, 21, and 28 d post artificial insemination. Pregnant cows had significantly higher plasma P4 levels and pregnant cows with higher P4 on 14 d tended to have higher P4 in the subsequent period of pregnancy. There was no difference in IL-4 and IL-6 expression between pregnant cows and non-pregnant cows, whereas plasma IL-1β was temporally upregulated on 21 d. The cytokines measured were not affected in either the high-P4 group (>11.1 ng·mL ) or the low-P4 group (<11.1 ng·mL ) in pregnant cows. A weak negative correlation between IL-1β and IL-6 was observed, but none of the cytokines was associated with a change in plasma P4. In conclusion, there was no clear relationship between P4 and Th immunity in maternal plasma in the pregnant cows, which differs from what occurs in humans and mice during early pregnancy.

Keywords： dairy cow     progesterone     pregnancy     cytokine    

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A Promising Anti-Cytokine-Storm Targeted Therapy for COVID-19: The Artificial-Liver Blood-Purification

Yimin Zhang, Liang Yu, LingLing Tang, Mengfei Zhu, Yanqi Jin, Zhouhan Wang, Lanjuan Li

Engineering 2021, Volume 7, Issue 1,   Pages 11-13 doi: 10.1016/j.eng.2020.03.006

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A giant step forward: chimeric antigen receptor T-cell therapy for lymphoma

Houli Zhao, Yiyun Wang, Elaine Tan Su Yin, Kui Zhao, Yongxian Hu, He Huang

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 711-725 doi: 10.1007/s11684-020-0808-3

Abstract: Nonetheless, the CAR-T therapy was usually associated with potentially lethal adverse effects, such as the cytokine

Keywords： chimeric antigen receptor T (CAR-T) cell     lymphoma     cytokine release syndrome (CRS)     immune effector cell-associated    

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Keratin 5-Cre-driven deletion of

Jun Yang, Lianqing Wang, Yingzhi Huang, Keqiang Liu, Chaoxia Lu, Nuo Si, Rongrong Wang, Yaping Liu, Xue Zhang

Frontiers of Medicine 2020, Volume 14, Issue 3,   Pages 305-317 doi: 10.1007/s11684-019-0722-8

Abstract: Our findings suggested that IL-36a might be a key inflammatory cytokine in the pathophysiology of AI

Keywords： acne inversa mouse model     interleukin 1 family     member 6     small proline rich protein 2D     key inflammatory cytokine    

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Endothelial dysfunction in COVID-19 calls for immediate attention: the emerging roles of the endothelium in inflammation caused by SARS-CoV-2

Weijian Hang, Chen Chen, Xin A. Zhang, Dao Wen Wang

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 638-643 doi: 10.1007/s11684-021-0831-z

Abstract: The COVID-19 pandemic has caused numerous deaths around the world. A growing body of evidence points to the important role of overwhelming inflammatory responses in the pathogenesis of COVID-19 and the effectiveness of anti-inflammation therapy against COVID-19 is emerging. In addition to affecting the lungs, COVID-19 can be a severe systemic inflammatory disease that is related to endothelial dysfunction. We are calling for closer attention to endothelial dysfunction in COVID-19 not only for fully revealing the pathogenic mechanism of COVID-19 but also for properly adjusting the strategy of clinical intervention.

Keywords： COVID-19     endothelial dysfunction     inflammation reaction     cytokine storm    

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The Scientific Foundation of Chinese Herbal Medicine against COVID-19 Perspective

Elaine Lai-Han Leung, Hu-Dan Pan, Yu-Feng Huang, Xing-Xing Fan, Wan-Ying Wang, Fang He, Jun Cai, Hua Zhou, Liang Liu

Engineering 2020, Volume 6, Issue 10,   Pages 1099-1107 doi: 10.1016/j.eng.2020.08.009

Abstract: starting with severe viral infection and suppression of the immune system and eventually progressing to cytokine

Keywords： Coronavirus disease 2019     Severe acute respiratory syndrome coronavirus     Chinese herbal medicine     Antiviral     Cytokine    

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Temporal Profiles of Antibody Responses, Cytokines, and Survival of COVID-19 Patients: A Retrospective Cohort Article

Li Liu, Heng-Gui Chen, Ying Li, Huijun Li, Jiaoyuan Li, Yi Wang, Shuang Yao, Chuan Qin, Shutao Tong, Xu Yuan, Xia Luo, Xiaoping Miao , An Pan, Zheng Liu, Liming Cheng

Engineering 2021, Volume 7, Issue 7,   Pages 958-965 doi: 10.1016/j.eng.2021.04.015

Abstract:

The longitudinal immunologic status of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients and its association with the clinical outcome are barely known. Thus, we sought to analyze the temporal profiles of specific antibodies, as well as the associations between the antibodies, proinflammatory cytokines, and survival of patients with coronavirus disease 2019 (COVID-19). A total of 1830 laboratory-confirmed COVID-19 cases were recruited. The temporal profiles of the virus, antibodies, and cytokines of the patients until 12 weeks since illness onset were fitted by the locally weighted scatter plot smoothing method. The mediation effect of cytokines on the associations between antibody responses and survival were explored by mediation analysis. Of the 1830 patients, 1435 were detectable for
SARS-CoV-2, while 395 were positive in specific antibodies only. Of the 1435 patients, 2.4% presented seroconversion for neither immunoglobulin G (IgG) nor immunoglobulin M (IgM) during hospitalization. The seropositive rates of IgG and IgM were 29.6% and 48.1%, respectively, in the first week, and plateaued within five weeks. For the patients discharged from the hospital, the IgM decreased slowly, while high levels of IgG were maintained at around 188 AU·mL1 for the 12 weeks since illness onset. In contrast, in the patients who subsequently died, IgM declined rapidly and IgG dropped to 87 AUmL1 at the twelfth week. Elevated interleukin-6, interleukin-8, interleukin-10, interleukin-1b, interleukin-2R, and tumor necrosis factor-a levels were observed in the deceased patients in comparison with the discharged patients, and 12.5% of the association between IgG level and mortality risk was mediated by these cytokines. Our study deciphers the temporal profiles of SARS-CoV-2-specific antibodies within the 12 weeks since illness onset and indicates the protective effect of antibody response on survival, which may help to guide prognosis estimation.

Keywords： Coronavirus disease 2019     Antibody response     Cytokine     Mortality     Viral load    

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Tocilizumab in patients with moderate or severe COVID-19: a randomized, controlled, open-label, multicenter trial

Dongsheng Wang, Binqing Fu, Zhen Peng, Dongliang Yang, Mingfeng Han, Min Li, Yun Yang, Tianjun Yang, Liangye Sun, Wei Li, Wei Shi, Xin Yao, Yan Ma, Fei Xu, Xiaojing Wang, Jun Chen, Daqing Xia, Yubei Sun, Lin Dong, Jumei Wang, Xiaoyu Zhu, Min Zhang, Yonggang Zhou, Aijun Pan, Xiaowen Hu, Xiaodong Mei, Haiming Wei, Xiaoling Xu

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 486-494 doi: 10.1007/s11684-020-0824-3

Abstract: Tocilizumab has been reported to attenuate the “cytokine storm” in COVID-19 patients.

Keywords： tocilizumab     coronavirus disease 2019 (COVID-19)     cytokine storm    

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Title Author Date Type Operation

Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes

Jianping Ye

Journal Article

Cytokine storm and translating IL-6 biology into effective treatments for COVID-19

Journal Article

Inflammation and liver tumorigenesis

Beicheng Sun, Michael Karin

Journal Article

High-affinity T cell receptors redirect cytokine-activated T cells (CAT) to kill cancer cells

Synat Kang, Yanyan Li, Yifeng Bao, Yi Li

Journal Article

Molecular characterization of two suppressor of cytokine signaling 1 genes (

Xue XU,Jiannan ZHANG,Juan LI,Yajun WANG

Journal Article

Management of cytokine release syndrome related to CAR-T cell therapy

Hongli Chen, Fangxia Wang, Pengyu Zhang, Yilin Zhang, Yinxia Chen, Xiaohu Fan, Xingmei Cao, Jie Liu, Yun Yang, Baiyan Wang, Bo Lei, Liufang Gu, Ju Bai, Lili Wei, Ruili Zhang, Qiuchuan Zhuang, Wanggang Zhang, Wanhong Zhao, Aili He

Journal Article

Phase I study of CBM.CD19 chimeric antigen receptor T cell in the treatment of refractory diffuse large B-cell lymphoma in Chinese patients

Journal Article

The relationship between progesterone and Th-related cytokines in plasma during early pregnancy in cows

Lei CHENG,Youdong XIN,Xiaohua LIU,Xiuzhong HU,Min XIANG,Dingfa WANG,Shuhong ZHAO

Journal Article

A Promising Anti-Cytokine-Storm Targeted Therapy for COVID-19: The Artificial-Liver Blood-Purification

Yimin Zhang, Liang Yu, LingLing Tang, Mengfei Zhu, Yanqi Jin, Zhouhan Wang, Lanjuan Li

Journal Article

A giant step forward: chimeric antigen receptor T-cell therapy for lymphoma

Houli Zhao, Yiyun Wang, Elaine Tan Su Yin, Kui Zhao, Yongxian Hu, He Huang

Journal Article

Keratin 5-Cre-driven deletion of

Jun Yang, Lianqing Wang, Yingzhi Huang, Keqiang Liu, Chaoxia Lu, Nuo Si, Rongrong Wang, Yaping Liu, Xue Zhang

Journal Article

Endothelial dysfunction in COVID-19 calls for immediate attention: the emerging roles of the endothelium in inflammation caused by SARS-CoV-2

Weijian Hang, Chen Chen, Xin A. Zhang, Dao Wen Wang

Journal Article

The Scientific Foundation of Chinese Herbal Medicine against COVID-19

Elaine Lai-Han Leung, Hu-Dan Pan, Yu-Feng Huang, Xing-Xing Fan, Wan-Ying Wang, Fang He, Jun Cai, Hua Zhou, Liang Liu

Journal Article

Temporal Profiles of Antibody Responses, Cytokines, and Survival of COVID-19 Patients: A Retrospective Cohort

Li Liu, Heng-Gui Chen, Ying Li, Huijun Li, Jiaoyuan Li, Yi Wang, Shuang Yao, Chuan Qin, Shutao Tong, Xu Yuan, Xia Luo, Xiaoping Miao , An Pan, Zheng Liu, Liming Cheng

Journal Article

Tocilizumab in patients with moderate or severe COVID-19: a randomized, controlled, open-label, multicenter trial

Dongsheng Wang, Binqing Fu, Zhen Peng, Dongliang Yang, Mingfeng Han, Min Li, Yun Yang, Tianjun Yang, Liangye Sun, Wei Li, Wei Shi, Xin Yao, Yan Ma, Fei Xu, Xiaojing Wang, Jun Chen, Daqing Xia, Yubei Sun, Lin Dong, Jumei Wang, Xiaoyu Zhu, Min Zhang, Yonggang Zhou, Aijun Pan, Xiaowen Hu, Xiaodong Mei, Haiming Wei, Xiaoling Xu

Journal Article