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in vivo predictive dissolution 1

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Improved dissolution and anti-inflammatory effect of ibuprofen by solid dispersion

Liyuan Chen, Qifeng Dang, Chengsheng Liu, Jun Chen, Lei Song, Xiguang Chen

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 195-203 doi: 10.1007/s11684-012-0189-3

Abstract:

The purpose of this study was to improve the dissolution rate and anti-inflammatory effect of ibuprofenThe dissolution of ibuprofen in urea was higher than in PEG4000 or mannitol.SDs were characterized in terms of dissolution, differential scanning calorimetry (DSC), X-ray diffraction In vitro release results indicated that the ibuprofen dissolution rate was improved by theThe dissolution rate and anti-inflammatory effect of ibuprofen were significantly enhanced by the ibuprofen-urea

Keywords: ibuprofen     solid dispersion     physical mixture     dissolution     anti-inflammatory effect    

Research progress on hydrothermal dissolution and hydrolysis of lignocellulose and lignocellulosic waste

Yan ZHAO, Wenjing LU, Jiajun CHEN, Xiangfeng ZHANG, Hongtao WANG

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 2,   Pages 151-161 doi: 10.1007/s11783-013-0607-z

Abstract: inadequate information on the conversion mechanisms of lignocellulose, particularly the reaction rules of dissolutionThis paper critically reviewed the progress done in the research and development of the hydrothermal dissolutionPrinciples, processes, and related studies on separate dissolution and asynchronous hydrolysis of lignin

Keywords: lignocellulosic waste     hydrothermal conversion     separate dissolution     asynchronous hydrolysis     mechanism    

Cadmium removal mechanistic comparison of three Fe-based nanomaterials: Water-chemistry and roles of Fe dissolution

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 12, doi: 10.1007/s11783-022-1586-8

Abstract:

● nZVI, S-nZVI, and nFeS were systematically compared for Cd(II) removal.

Keywords: Nano zero valent iron     Sulfided zero valent iron     FeS     Cd(II) immobilization     Fe dissolution    

Effects of rotor and stator geometry on dissolution process and power consumption in jet-flow high shear

Lin Yang, Wenpeng Li, Junheng Guo, Wei Li, Baoguo Wang, Minqing Zhang, Jinli Zhang

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 2,   Pages 384-398 doi: 10.1007/s11705-020-1928-7

Abstract: The jet-flow high shear mixer (JF-HSM) is a new type of intensified equipment with special configurations of the rotor and the stator. The mass transfer property and power consumption were studied in the solid-liquid system for a series of JF-HSMs involving different configuration parameters, such as rotor diameter, rotor blade inclination, rotor blade bending direction, stator diameter, and stator bottom opening diameter. The flow characteristics were examined by computational fluid dynamic simulations. Results indicate that the turbulent power consumption of the JF-HSM is affected by the change in rotor blade inclination and stator bottom opening. With the increase in the shear head size and the change in the rotor into a backward-curved blade, the solid-liquid mass transfer rate can be remarkably increased under the same input power. Dimensionless correlations for the mass transfer coefficient and power consumption were obtained to guide the scale-up design and selection of such a new type of equipment to intensify the overall mixing efficiency.

Keywords: jet-flow high shear mixer     solid particle dissolution     power consumption characteristics     CFD Simulation    

Crystal modification of rifapentine using different solvents

Kun ZHOU, Jun LI, Jianhong LUO, Dongsheng ZHENG,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 1,   Pages 65-69 doi: 10.1007/s11705-009-0302-6

Abstract: The comparative dissolution behaviors of the newly developed crystals and of rifapentine without beingThe dissolution rate of newly developed crystals was found to be higher than that of rifapentine withoutHowever, the modified crystal obtained from acetic acid shows the lower dissolution rate than crystals

Keywords: identical     scanning calorimetry     different     comparative dissolution     structure modification    

Oral product input to the GI tract: GIS an oral product performance technology

Gordon L. Amidon, Yasuhiro Tsume

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 516-520 doi: 10.1007/s11705-017-1658-7

Abstract: We have suggested to select different dissolution methodologies for this optimization based on BCS SubclassesIn this article, we present the predicted drug dissolution profile of ketoconazole as a model drugThis dissolution system allows the monitoring of the drug dissolution phenomena and the observation ofsupersaturation and the precipitation of pharmaceutical products, which is useful information to predict dissolution

Keywords: GIS     in vivo predictive dissolution     ketoconazole     BCS subclassification     supersaturation    

Modeling of specific structure crystallization coupling with dissolution

Yuanhui JI, Hongliang QIAN, Chang LIU, Xiaohua LU, Xin FENG, Xiaoyan JI,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 1,   Pages 52-56 doi: 10.1007/s11705-009-0301-7

Abstract: coefficient model of the solution, the second is Solid-Liquid equilibrium, the third and fourth are the dissolutionmechanisms of complex structure formation and microphase transition can be analyzed by combining the dissolution

Keywords: structure crystallization     activity coefficient     reference     KCl     dissolution    

Dissolution and enzymatic hydrolysis of casein micelles studied by dynamic light scattering

LIU Rui, QI Wei, SU Rongxin, ZHANG Yubin, JIN Fengmin, HE Zhimin

Frontiers of Chemical Science and Engineering 2007, Volume 1, Issue 2,   Pages 123-127 doi: 10.1007/s11705-007-0023-7

Abstract: The effects of temperature, ionic strength, and enzymatic hydrolysis on the average hydrodynamic radius () of casein micelles in phosphate buffer were studied by using dynamic light scattering. The results showed that the average value of casein micelles decreased irreversibly during the heating, decreased with the increase of ionic strength in lower ionic strength solution (less than 0.05 mol/L), but opposite in higher ionic strength solution (above 0.1 mol/L). The value of casein increased rapidly during the process of enzymatic hydrolysis, and the structural model of casein micelles in the enzymatic hydrolysis process was also proposed, i.e. the casein micelle changed from compact sphere into unfolded and regularly flocky peptides.

Keywords: compact     strength     temperature     regularly flocky     heating    

Construction of nitrogen-doped carbon cladding LiMnO film electrode with enhanced stability for electrochemically selective extraction of lithium ions

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 12,   Pages 2050-2060 doi: 10.1007/s11705-023-2343-7

Abstract: Reducing the dissolution of Mn from LiMn2O4 (LMO) and enhancing the stability ofThe modified C-N@LMO film electrode exhibited lower Mn dissolution and better cyclic stability than theThe dissolution ratio of Mn from the C-N@LMO film electrode decreased by 42% compared to the LMO film

Keywords: LiMn2O4     lithium extraction     surface coating     cyclic stability     Mn dissolution    

Title Author Date Type Operation

Improved dissolution and anti-inflammatory effect of ibuprofen by solid dispersion

Liyuan Chen, Qifeng Dang, Chengsheng Liu, Jun Chen, Lei Song, Xiguang Chen

Journal Article

Research progress on hydrothermal dissolution and hydrolysis of lignocellulose and lignocellulosic waste

Yan ZHAO, Wenjing LU, Jiajun CHEN, Xiangfeng ZHANG, Hongtao WANG

Journal Article

Cadmium removal mechanistic comparison of three Fe-based nanomaterials: Water-chemistry and roles of Fe dissolution

Journal Article

Effects of rotor and stator geometry on dissolution process and power consumption in jet-flow high shear

Lin Yang, Wenpeng Li, Junheng Guo, Wei Li, Baoguo Wang, Minqing Zhang, Jinli Zhang

Journal Article

Crystal modification of rifapentine using different solvents

Kun ZHOU, Jun LI, Jianhong LUO, Dongsheng ZHENG,

Journal Article

Oral product input to the GI tract: GIS an oral product performance technology

Gordon L. Amidon, Yasuhiro Tsume

Journal Article

Modeling of specific structure crystallization coupling with dissolution

Yuanhui JI, Hongliang QIAN, Chang LIU, Xiaohua LU, Xin FENG, Xiaoyan JI,

Journal Article

Dissolution and enzymatic hydrolysis of casein micelles studied by dynamic light scattering

LIU Rui, QI Wei, SU Rongxin, ZHANG Yubin, JIN Fengmin, HE Zhimin

Journal Article

Construction of nitrogen-doped carbon cladding LiMnO film electrode with enhanced stability for electrochemically selective extraction of lithium ions

Journal Article