Search | Engineering

Subscribe Submit

Home Journals Focus Achievement Fronts About Us 中文版

Resource Type

Journal Article 4

Year

2023 1

2020 1

2008 1

2007 1

Keywords

Attitude constraints 1

Distributed signed-distance-field 1

Industrial robots 1

LEW-to-DA 1

MACS 1

Path planning 1

Path simplification 1

chimeric antigen receptor T (CAR-T) cell 1

controller 1

cytokine release syndrome (CRS) 1

cytometry 1

effector 1

end-effector 1

five-hundred 1

immune effector cell-associated neurotoxicity syndrome (ICANS) 1

lymphoma 1

magnetic 1

simulation 1

telescope 1

open ︾

Search scope:

排序： Display mode:

Task-space position/attitude tracking control of FAST fine tuning system

QI Lin, ZHANG Hui, DUAN Guanghong

Frontiers of Mechanical Engineering 2008, Volume 3, Issue 4, Pages 392-399 doi: 10.1007/s11465-008-0056-8

Abstract: Based on the quaternion algebra, a novel model-independent task-space PD controller that ensures end-effector

Keywords： telescope five-hundred end-effector controller simulation

HTML PDF Collect

A giant step forward: chimeric antigen receptor T-cell therapy for lymphoma

Houli Zhao, Yiyun Wang, Elaine Tan Su Yin, Kui Zhao, Yongxian Hu, He Huang

Frontiers of Medicine 2020, Volume 14, Issue 6, Pages 711-725 doi: 10.1007/s11684-020-0808-3

Abstract: The combination of the immunotherapy (i.e., the use of monoclonal antibodies) and the conventional chemotherapy increases the long-term survival of patients with lymphoma. However, for patients with relapsed or treatment-resistant lymphoma, a novel treatment approach is urgently needed. Chimeric antigen receptor T (CAR-T) cells were introduced as a treatment for these patients. Based on recent clinical data, approximately 50% of patients with relapsed or refractory B-cell lymphoma achieved complete remission after receiving the CD19 CAR-T cell therapy. Moreover, clinical data revealed that some patients remained in remission for more than two years after the CAR-T cell therapy. Other than the CD19-targeted CAR-T, the novel target antigens, such as CD20, CD22, CD30, and CD37, which were greatly expressed on lymphoma cells, were studied under preclinical and clinical evaluations for use in the treatment of lymphoma. Nonetheless, the CAR-T therapy was usually associated with potentially lethal adverse effects, such as the cytokine release syndrome and the neurotoxicity. Therefore, optimizing the structure of CAR, creating new drugs, and combining CAR-T cell therapy with stem cell transplantation are potential solutions to increase the effectiveness of treatment and reduce the toxicity in patients with lymphoma after the CAR-T cell therapy.

Keywords： chimeric antigen receptor T (CAR-T) cell lymphoma cytokine release syndrome (CRS) immune effector cell-associated

HTML PDF Collect

Biological features of intrahepatic CD4+CD25+ T cells in the naturally tolerance of rat liver transplantation

LU Ling, ZHANG Feng, PU Liyong, YAO Aihua, YU Yue, SUN Beicheng, LI Guoqiang, WANG Xuehao

Frontiers of Medicine 2007, Volume 1, Issue 4, Pages 373-376 doi: 10.1007/s11684-007-0072-9

Abstract: And their suppression on the proliferation of CD4CD25 T effector cells was analyzed by cell proliferation

Keywords： magnetic LEW-to-DA effector MACS cytometry

HTML PDF Collect

distributed variable density path search and simplification method for industrial manipulators with end-effector Research Article

Jin WANG, Shengjie LI, Haiyun ZHANG, Guodong LU, Yichang FENG, Peng WANG, Jituo LI,dwjcom@zju.edu.cn

Frontiers of Information Technology & Electronic Engineering 2023, Volume 24, Issue 4, Pages 536-552 doi: 10.1631/FITEE.2200353

Abstract: In many robot operation scenarios, the end-effector’s of movement are indispensable for the task processexperimental results verify the performance and effectiveness of the proposed DVDP-AC method under end-effector

Keywords： Path planning Industrial robots Distributed signed-distance-field Attitude constraints Path simplification