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Journal Article 2

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2019 1

2001 1

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biomaterial 1

extension detecting technology 1

extrinsic 1

extrinsic barrier 1

intrinsic regeneration capacity 1

spinal cord injury 1

transform of matter element 1

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Extension Detecting Technology

Yu Yongquan

Strategic Study of CAE 2001, Volume 3, Issue 4,   Pages 88-94

Abstract: EDT takes advantage of the concept of matter element and the related methods of extrinsic.

Keywords： extension detecting technology     extrinsic     transform of matter element    

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Combination of biomaterial transplantation and genetic enhancement of intrinsic growth capacities to promote CNS axon regeneration after spinal cord injury

Bin Yu, Xiaosong Gu

Frontiers of Medicine 2019, Volume 13, Issue 2,   Pages 131-137 doi: 10.1007/s11684-018-0642-z

Abstract: The inhibitory environment that surrounds the lesion site and the lack of intrinsic regenerative capacity of the adult mammalian central nervous system (CNS) impede the regrowth of injured axons and thereby the reestablishment of neural circuits required for functional recovery after spinal cord injuries (SCI). To circumvent these barriers, biomaterial scaffolds are applied to bridge the lesion gaps for the regrowing axons to follow, and, often by combining stem cell transplantation, to enable the local environment in the growth-supportive direction. Manipulations, such as the modulation of PTEN/mTOR pathways, can also enhance intrinsic CNS axon regrowth after injury. Given the complex pathophysiology of SCI, combining biomaterial scaffolds and genetic manipulation may provide synergistic effects and promote maximal axonal regrowth. Future directions will primarily focus on the translatability of these approaches and promote therapeutic avenues toward the functional rehabilitation of patients with SCIs.

Keywords： spinal cord injury     biomaterial     extrinsic barrier     intrinsic regeneration capacity    

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Title Author Date Type Operation

Extension Detecting Technology

Yu Yongquan

Journal Article

Combination of biomaterial transplantation and genetic enhancement of intrinsic growth capacities to promote CNS axon regeneration after spinal cord injury

Bin Yu, Xiaosong Gu

Journal Article