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Journal Article 7

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genotoxicity 3

2 1

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6-trichlorophenol 1

Umu test 1

Vicia faba 1

Asparagine 1

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Chlorination 1

Dichloroacetonitrile 1

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Comparative genotoxicity of water processed by three drinking water treatment plants with different water

Ting Zhang, Heze Liu, Yiyuan Zhang, Wenjun Sun, Xiuwei Ao

Frontiers of Environmental Science & Engineering 2020, Volume 14, Issue 3, doi: 10.1007/s11783-020-1214-4

Abstract: Genotoxicity of substances is unknown in the water after treatment processes.Genotoxicity decreased by activated carbon treatment but increased by chlorination.Halogenated hydrocarbons and aromatic compounds contribute to genotoxicity.Genotoxicity was assessed by umu test; acute and chronic toxicity by ECOSAR.Inconsistent results confirmed that genotoxicity cannot be assessed by ECOSAR.

Keywords: Drinking water     Treatment process     Genotoxicity     Umu test     Ecological Structure-Activity Relationship    

Genotoxicity evaluation of surface waters located in urban area of Xi’an City using

Yongjun LIU, Aining ZHANG, Xiaoyan MA, Xiaochang WANG

Frontiers of Environmental Science & Engineering 2013, Volume 7, Issue 6,   Pages 860-866 doi: 10.1007/s11783-012-0462-3

Abstract: In this study, micronucleus (MCN) and chromosome aberration (CA) tests in root tip cells were carried out in order to assess the water quality and the comprehensive genotoxic potential of surface waters located in the urban area of Xi’an City, China. For these evaluations, water samples from different surface waters (four rivers, two lakes, two biological treatment plant effluents) were collected, the ultra-pure water and methyl methanesulfonate solution was used as the negative and positive control, respectively. In our results, highly significant differences in MCN permillage (average number of micronuclei per 1000 cells), CA frequencies and PI (pollution index) values were found among three rivers and two WWTP effluents, the tested samples from two rivers caused the decrease of mitotic index over 22% compared with the negative control. No significant changes were observed in micronuclei and chromosome aberrations frequencies at one river and two lakes during the period of test (wet season). These results point out a poor state of the water quality and genotoxic activity of the main surface waters in Xi’an City. It is recommended to establish a monitoring program for the presence of genotoxic agents in these surface waters.

Keywords: genotoxicity     surface water     evaluation     Vicia faba    

Change in genotoxicity of wastewater during chlorine dioxide and chlorine disinfections and the influence

WANG Lisha, HU Hongying, WANG Chao, Koichi Fujie

Frontiers of Environmental Science & Engineering 2007, Volume 1, Issue 1,   Pages 18-22 doi: 10.1007/s11783-007-0003-7

Abstract: The effects of chlorine dioxide and chlorine disinfections on the genotoxicity of different biologicallyThe experiment results showed that when chlorine dioxide dosage was increased from 0 to 30 mg/L, the genotoxicityIt was then found that ammonia nitrogen did not affect the change of genotoxicity during chlorine dioxidedisinfection of wastewater, while it greatly affected the change of genotoxicity during chlorine disinWhen the concentration of ammonia nitrogen was low (< 10 20 mg/L), the genotoxicity of wastewater decreased

of important precursors and theoretical toxicity evaluation of byproducts driving cytotoxicity and genotoxicity

Qian-Yuan Wu, Yi-Jun Yan, Yao Lu, Ye Du, Zi-Fan Liang, Hong-Ying Hu

Frontiers of Environmental Science & Engineering 2020, Volume 14, Issue 2, doi: 10.1007/s11783-019-1204-6

Abstract: toxicity index during chlorination • Dichloroacetonitrile might be a driving DBP for cytotoxicity and genotoxicitytoxicity using a theoretical toxicity evaluation of contributions to the cytotoxicity index (CTI) and genotoxicity

Keywords: Chlorination     Dichloroacetonitrile     Aspartic acid     Asparagine     Toxicity index    

Chemical identification and genotoxicity analysis of petrochemical industrial wastewater

Jing ZHANG, Shigong WANG, Can WANG, Hongying HU

Frontiers of Environmental Science & Engineering 2012, Volume 6, Issue 3,   Pages 350-359 doi: 10.1007/s11783-012-0404-0

Abstract: The actual harmful effects of industrial wastewater can not be reflected by the conventional water quality index. Therefore, the change in dissolved organic matter and the genetic toxicity of petrochemical wastewater were observed in the current study by examining the wastewater treatment plant of a large petrochemical enterprise in Northwest China. Using XAD-8, MSC, and DA-7 resins, the wastewater was separated into six fractions, namely, hydrophobic acid (HOA), hydrophobic neutral (HOB), hydrophobic alkaline, hydrophilic acid, hydrophilic alkaline, and hydrophilic neutral. Umu-test was used to detect the genetic toxicity of the wastewater samples, and fluorescence spectra were also obtained to examine genetic toxic substances. The results show that wastewater treatment facilities can effectively reduce the concentration of organic matter in petrochemical wastewater ( <0.05). However, the mixing of aniline wastewater can increase the amount of organic carbon ( <0.05) and can overload facilities. This finding shows that the mixed collection and joint treatment of different types of petrochemical wastewater can affect the water quality of the effluent. Particularly, hydrophobic substances can be difficult to remove and account for a relatively large proportion of the effluent. The mixture of aniline wastewater can increase the genetic toxicity of the effluent ( <0.05), and biologic treatment can not effectively decrease the toxicity. Most of the genetic toxicology may exist in the HOA and HOB fractions. Fluorescence spectroscopy also confirms this result, and tryptophan-like substances may play an important role in genetic toxicity.

Keywords: dissolved organic matter     resin fraction     genetic toxicity     fluorescence excitation and emission matrix    

Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity

Chuanfeng Wu, Cynthia E. Dunbar

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 356-371 doi: 10.1007/s11684-011-0159-1

Abstract: Numerous studies have been performed to understand the molecular basis of vector-mediated genotoxicityprogenitor cells due to integrating gene transfer vectors, discuss the available assays for predicting genotoxicityand mapping vector integration sites, and introduce newly-developed approaches for minimizing genotoxicity

Keywords: gene therapy     hematopoietic stem cells     insertional mutagenesis     genotoxicity     induced pluripotent stem cell    

Susceptibility of male and female Japanese medaka (

Nannan LIU, Mei MA, Yiping XU, Jinmiao ZHA, Kaifeng RAO, Zijian WANG

Frontiers of Environmental Science & Engineering 2013, Volume 7, Issue 1,   Pages 77-84 doi: 10.1007/s11783-012-0466-z

Abstract: 2,4,6-trichlorophenol (2,4,6-TCP) is a widespread probable human carcinogen and has been proven to have genotoxicityHowever, little genotoxicity information and no micronuclei induction data for 2,4,6-TCP is availablefrequencies of all of the groups increased in a dose-dependent manner, which indicated the potential genotoxicity

Keywords: 2     4     6-trichlorophenol     genotoxicity     Japanese medaka     piscine micronucleus test in peripheral erythrocytes    

Title Author Date Type Operation

Comparative genotoxicity of water processed by three drinking water treatment plants with different water

Ting Zhang, Heze Liu, Yiyuan Zhang, Wenjun Sun, Xiuwei Ao

Journal Article

Genotoxicity evaluation of surface waters located in urban area of Xi’an City using

Yongjun LIU, Aining ZHANG, Xiaoyan MA, Xiaochang WANG

Journal Article

Change in genotoxicity of wastewater during chlorine dioxide and chlorine disinfections and the influence

WANG Lisha, HU Hongying, WANG Chao, Koichi Fujie

Journal Article

of important precursors and theoretical toxicity evaluation of byproducts driving cytotoxicity and genotoxicity

Qian-Yuan Wu, Yi-Jun Yan, Yao Lu, Ye Du, Zi-Fan Liang, Hong-Ying Hu

Journal Article

Chemical identification and genotoxicity analysis of petrochemical industrial wastewater

Jing ZHANG, Shigong WANG, Can WANG, Hongying HU

Journal Article

Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity

Chuanfeng Wu, Cynthia E. Dunbar

Journal Article

Susceptibility of male and female Japanese medaka (

Nannan LIU, Mei MA, Yiping XU, Jinmiao ZHA, Kaifeng RAO, Zijian WANG

Journal Article