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Atypical pituitary hormone–target tissue axis

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 1-17 doi: 10.1007/s11684-022-0973-7

Abstract: However, a number of studies have shown that multiple types of pituitary hormone receptors are widelyEach pituitary gland-derived hormone exhibits a wide range of nonconventional biological effects in thesehormone, luteinizing hormone, adrenocorticotrophic hormone, and prolactin when they act on non-classicalorgans were summarized, defined by the novel concept of an “atypical pituitary hormone–target tissueThe continued exploration of the physiology of the “atypical pituitary hormone–target tissue axis” could

Keywords： thyroid-stimulating hormone     follicle-stimulating hormone     luteinizing hormone     adrenocorticotrophichormone     prolactin    

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Clinical evaluation of recombinant human growth hormone injection in children with growth hormone deficiency

Ling HOU, Xiaoping LUO, Minlian DU, Huamei MA, Chunxiu GONG, Yuchuan LI, Shuixian SHEN, Zhuhui ZHAO, Li LIANG, Guanping DONG, Chaoying YAN, Hongwei DU

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 171-176 doi: 10.1007/s11684-009-0027-4

Abstract: Recombinant human growth hormone (rhGH) has been widely used in the clinical treatment of growth hormonecurrent study was to evaluate the efficacy and safety of rhGH injection for the treatment of growth hormoneWe conclude that rhGH injection is a safe and effective drug for treatment of growth hormone deficiency

Keywords： recombinant human growth hormone     injection     growth hormone deficiency    

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How to judge the association of postmenopausal hormone therapy and the risk of breast cancer

Ling XU

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 290-293 doi: 10.1007/s11684-010-0093-7

Abstract: The relevance of postmenopausal hormone therapy (HT) for breast cancer risk has been long debated, although

Keywords： breast cancer     postmenopausal hormone therapy     unopposed estrogen therapy     combined estrogen-progestin therapy    

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Sensitivity of supplementation of thyroid hormone on treatment of idiopathic short-stature children duringtherapy with recombinant human growth hormone

Wei Wang, Shuqin Jiang, Zhirui Cui, Xiangyang Luo, Lingli Shi, Heli Zheng

Frontiers of Medicine 2018, Volume 12, Issue 5,   Pages 580-585 doi: 10.1007/s11684-017-0585-9

Abstract:

This study aimed to evaluate the effects of thyroid hormone supplementation on growth rate of childrenwith idiopathic short stature (ISS) and low-normal serum free thyroxine FT4 who were receiving growth hormoneDuring the first year, the lower FT4 group featured lower FT3, FT4, thyroid stimulating hormone (TSH)In children with ISS, the negative effect of thyroid hormone deficiency on growth rate should be consideredwhen FT4 level lies in the low-normal range prior to recombinant human growth hormone treatment.

Keywords： therapeutic     idiopathic short-stature children     free T4     the first year     recombinant human growth hormone    

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Pituitary-ovarian hormone and follicular development of various combined oral contraceptives regimens

Huang Pei,Huang Xunbin

Strategic Study of CAE 2015, Volume 17, Issue 6,   Pages 16-20

Abstract: of estrogen and progestin, secondarily leading to suppression of endogenous gonadotropin and gonadal hormoneDuring the hormone-free interval (HFI), COCs users experience activation of their pituitary–ovarian

Keywords： COCs     HFI     hormone     follicle    

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RECENT ADVANCES IN THE REGULATION OF CLIMACTERIC FRUIT RIPENING: HORMONE, TRANSCRIPTION FACTOR AND EPIGENETIC

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 2,

Abstract:

Fruit ripening is a complex developmental process made up of genetically programmed physiological and biochemical activities. It culminates in desirable changes in the structural and textural properties and is governed by a complex regulatory network. Much is known about ethylene, one of the most important metabolites promoting the ripening of climacteric fruits. However, the dynamic interplay between phytohormones also plays an important part. Additional regulatory factors such as transcription factors (TFs) and epigenetic modifications also play vital role in the regulation of climacteric fruit ripening. Here, we review and evaluate the complex regulatory network comprising interactions between hormones and the action of TFs and epigenetic modifications during climacteric fruit ripening.

 

Keywords： climacteric fruit ripening / phytohormones / TFs / epigenetic modifications    

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RECENT ADVANCES IN THE REGULATION OF CLIMACTERIC FRUIT RIPENING: HORMONE, TRANSCRIPTION FACTOR AND EPIGENETIC

Yinglin JI, Mingyang XU, Aide WANG

Frontiers of Agricultural Science and Engineering   Pages 314-334 doi: 10.15302/J-FASE-2021386

Abstract: Fruit ripening is a complex developmental process made up of genetically programmed physiological and biochemical activities. It culminates in desirable changes in the structural and textural properties and is governed by a complex regulatory network. Much is known about ethylene, one of the most important metabolites promoting the ripening of climacteric fruits. However, the dynamic interplay between phytohormones also plays an important part. Additional regulatory factors such as transcription factors (TFs) and epigenetic modifications also play vital role in the regulation of climacteric fruit ripening. Here, we review and evaluate the complex regulatory network comprising interactions between hormones and the action of TFs and epigenetic modifications during climacteric fruit ripening.

Keywords： climacteric fruit ripening     phytohormones     TFs     epigenetic modifications    

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The study of ovary development and steroid hormone changes in Alosa sapidissima

Hong Lei,Li Zhaoxin,Chen Chao,Guo Zhenglong,Wang Weifang,Lei Jilin

Strategic Study of CAE 2014, Volume 16, Issue 9,   Pages 86-92

Abstract:

In this study, the morphological changes of ovary development and variation of correlated plasma sex steroids levels were detected in Alosa sapidissima. The result shown that Alosa sapidissima belongs to the non-synchronized multiple batch spawner; based on size, shape and external color, the development of ovary was divided into six stages; according to changes of inner structures, yolk accumulating and development of follicle cells, the oogenesis could be divided into six phases. There were no significant differences about hepatosomatic index (HSI) and condition factor (CF) during the ovarian maturation cycle, but gonadosomatic index (GSI) and 17β- estradiol (E2) were found to increase during the peak phase of vitellogenic growth corresponding to the ovary development.

Keywords： Alosa sapidissima     ovary development     oogenesis     histology     morphology     steroid hormone    

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Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factor

Wenjie Zhu, Binghe Xu

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 208-220 doi: 10.1007/s11684-020-0795-4

Abstract: New targeted therapies have been developed to overcome resistance to endocrine therapy (ET) and improve the outcome of HR /HER2 advanced breast cancer (ABC). We conducted a meta-analysis and systemic review on randomized controlled trials evaluating various targeted therapies in combination with ET in HR /HER2 ABC. PUBMED and EMBASE databases were searched for eligible trials. Hazard ratios (HRs) for progression-free survival (PFS), odds ratios (ORs) for objective response rate (ORR), clinical benefit rate (CBR), and toxicity were meta-analyzed. Twenty-six studies with data on 10 347 patients were included and pooled. The addition of cyclin-dependent kinase 4/6 inhibitors to ET significantly improved median PFS (pooled HR= 0.547, <0.001), overall survival (pooled HR= 0.755, <0.001), and tumor response rates (ORR, pooled OR= 1.478, <0.001; CBR, pooled OR= 1.201, <0.001) with manageable toxicities (pooled OR= 3.280, <0.001). The mammalian targets of rapamycin inhibitors and exemestane were not clinically beneficial for this pooled population including ET-naïve and ET-resistant patients. Moderate improvement in PFS (pooled HR= 0.686, <0.001) yet pronounced toxicities (pooled OR= 2.154, <0.001) were noted in the combination of phosphatidylinositol-4,5-bisphosphate 3-kinase inhibitors with fulvestrant. Future studies are warranted to optimize the population and the dosing sequence of these available options.

Keywords： endocrine-resistant     HR+/HER2- advanced breast cancer     randomized clinical trials     meta-analysis     targeted therapy    

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Role of water chemistry on estrone removal by nanofiltration with the presence of hydrophobic acids

Xue JIN,Jiangyong HU

Frontiers of Environmental Science & Engineering 2015, Volume 9, Issue 1,   Pages 164-170 doi: 10.1007/s11783-014-0747-9

Abstract: organic matter (HpoA) extracted from treated effluent has been known to improve the rejection of steroid hormone

Keywords： indirect potable water reuse     steroid hormone     nanofiltration(NF)     rejection     water chemistry     hydrophobic    

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Long-term results of suppressing thyroid-stimulating hormone during radiotherapy to prevent primary hypothyroidism

Maura Massimino, Marta Podda, Lorenza Gandola, Emanuele Pignoli, Ettore Seregni, Carlo Morosi, Filippo Spreafico, Andrea Ferrari, Emilia Pecori, Monica Terenziani

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 101-107 doi: 10.1007/s11684-020-0752-2

Abstract: commonly occurs after radiotherapy (RT), and coincides with increased circulating thyroid-stimulating hormone

Keywords： iatrogenic primary hypothyroidism     late effects of radiotherapy     long-term follow-up     medulloblastoma     Hodgkin lymphoma    

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Molecular characterization of two suppressor of cytokine signaling 1 genes (

Xue XU,Jiannan ZHANG,Juan LI,Yajun WANG

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 1,   Pages 73-83 doi: 10.15302/J-FASE-2015044

Abstract: further demonstrated that transient expression of and can significantly inhibit chicken growth hormonetogether, these data suggest that both cSOCS1a and cSOCS1b may function as negative regulators of cytokine/hormone

Keywords： chicken     SOCS1a     SOCS1b     growth hormone     prolactin    

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Effect of repeated gonadotropin stimulation on ovarian reserves and proliferation of ovarian surface epithelium in mice

Linlin LIANG, Bei XU, Guijin ZHU

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 220-226 doi: 10.1007/s11684-009-0037-2

Abstract: This study aimed to evaluate the effect of repeated ovarian stimulation (OS) on the ovarian follicular population and morphology in female mice and its influence on the embryo’s developmental ability, and the profile of the ovarian surface epithelium (OSE). A total of 75 mice were enrolled in this experiment and randomly assigned into three groups: repeated ovarian stimulated group [ =25; receiving 5 IU pregnant mare serum gonadotrophin (PMSG) and human chorionic gonadotropin (hCG) at 6 day intervals for 5 cycles]; single ovarian stimulated group ( =25; receiving 5 IU PMSG and hCG for 1 cycle), and control group ( =25; without additional treatment). The follicle number at various stages and the morphologies were recorded respectively in the three groups. The harvested oocytes or embryos, cleavage rate, good quality embryo rate, and blastocyst production rate were counted and calculated, and the proliferations of ovarian surface epithelium were evaluated respectively. In the three groups, the single ovarian stimulation treatment significantly increased the mean number of ovarian oocytes or embryos (39.25±10.77 one-cell embryos/female); on the other hand, repeated gonadotropin stimulation obtained the lowest mean number (5.15± 2.81 eggs/female, <0.01). Repeated ovarian stimulation also tended to decrease normal follicles of primary follicles (66.67%) and secondary follicles (72.86%), and got the lowest cleavage rate (67.47%), lowest good quality embryo rate (2.41%), and lowest blastocyst production rate (0). The OSE cells adjacent to the antral follicles and corpus luteum (CL) in the repeated ovarian stimulated group (81.8%) had a significantly higher proliferation rate than the other groups. The proliferation rate of the OSE in the single ovarian stimulated group (56.4%) was significantly higher than that in the control group (37.5%) ( <0.01). In conclusion, single ovarian stimulation may produce more oocytes/embryos. However, repeated gonadotropin stimulation may have a negative effect on the ovarian follicular quality, the number of mature retrieved oocytes, and the embryo quality, even increasing the chance of ovarian cancer.

Keywords： gonadotropin-releasing hormone     ovarian reserve     embryo developmental ability     ovarian surface epithelium    

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Energy-aware fuzzy job-shop scheduling for engine remanufacturing at the multi-machine level

Jiali ZHAO, Shitong PENG, Tao LI, Shengping LV, Mengyun LI, Hongchao ZHANG

Frontiers of Mechanical Engineering 2019, Volume 14, Issue 4,   Pages 474-488 doi: 10.1007/s11465-019-0560-z

Abstract: An improved adaptive genetic algorithm was developed by using the hormone modulation mechanism to deal

Keywords： remanufacturing scheduling     adaptive genetic algorithm     energy efficiency     sustainable remanufacturing     hormone    

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Full length cDNA cloning and expression of luteinizing hormone (LH) and which serum concentration was

Liu Xuezhou,Shi Bao,Wang Shanshan,Xu Yongjiang,Li Xiaoxiao

Strategic Study of CAE 2014, Volume 16, Issue 9,   Pages 50-60

Abstract:

The full length cDNA of LH has been cloned from pituitary of half smooth tongue sole C. Günther by using RACE technology for the first time. The cDNA of LH is 670 bp，and the open reading frame is 477 bp encoding peptides of 158 amino acid. Multiple amino acid sequences alignments were performed among vertebrates，and the results showed that tongue sole LH mature peptide was the most similar to their orthologs of Pleuronectiformes and Perciformes which was 58 %～68 % identity. And 12 conserved cysteine residues and 1 N-linked glycosylation site were found in the deduced amino acid sequence. Real-time PCR analysis showed that LH mRNA was expressed in all twelve tissues including brain，pituitary，ovary and so on. The highest expression level was in pituitary. And the stronger amplification signals were detected in the brain and gonad than all other non- pituitary tissues. It suggested that LH may had the more physiological functions because LH mRNA of tongue sole expressed widely in non-pituitary tissues. Quantitative real- time PCR was used for analyzing the expression of female C. semilaevis LH mRNA in the reproductive cycle. The results showed that LH mRNA was expressed in all three tissues including brain，pituitary and ovary from the stage Ⅱto stage Ⅵ， and the highest expression level appeared on the stage Ⅳ and stage Ⅴwhich suggested that the main function of LH is to promote eggs finally mature and discharge. Radio immunoassay （RIA）marked by 125I was used to detect the concentration of plasma LH in C.semilaevis. The results showed that the biggest plasma LH concentration appareed on the stage of Ⅴwhich also suggested that the main function of LH was to promote eggs finally mature and discharge.

Keywords： Cynoglossus semilaevis Günther     LH     cDNA cloning     Quantitative real-time PCR     RIA    

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Title Author Date Type Operation

Atypical pituitary hormone–target tissue axis

Journal Article

Clinical evaluation of recombinant human growth hormone injection in children with growth hormone deficiency

Ling HOU, Xiaoping LUO, Minlian DU, Huamei MA, Chunxiu GONG, Yuchuan LI, Shuixian SHEN, Zhuhui ZHAO, Li LIANG, Guanping DONG, Chaoying YAN, Hongwei DU

Journal Article

How to judge the association of postmenopausal hormone therapy and the risk of breast cancer

Ling XU

Journal Article

Sensitivity of supplementation of thyroid hormone on treatment of idiopathic short-stature children duringtherapy with recombinant human growth hormone

Wei Wang, Shuqin Jiang, Zhirui Cui, Xiangyang Luo, Lingli Shi, Heli Zheng

Journal Article

Pituitary-ovarian hormone and follicular development of various combined oral contraceptives regimens

Huang Pei,Huang Xunbin

Journal Article

RECENT ADVANCES IN THE REGULATION OF CLIMACTERIC FRUIT RIPENING: HORMONE, TRANSCRIPTION FACTOR AND EPIGENETIC

Journal Article

RECENT ADVANCES IN THE REGULATION OF CLIMACTERIC FRUIT RIPENING: HORMONE, TRANSCRIPTION FACTOR AND EPIGENETIC

Yinglin JI, Mingyang XU, Aide WANG

Journal Article

The study of ovary development and steroid hormone changes in Alosa sapidissima

Hong Lei,Li Zhaoxin,Chen Chao,Guo Zhenglong,Wang Weifang,Lei Jilin

Journal Article

Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factor

Wenjie Zhu, Binghe Xu

Journal Article

Role of water chemistry on estrone removal by nanofiltration with the presence of hydrophobic acids

Xue JIN,Jiangyong HU

Journal Article

Long-term results of suppressing thyroid-stimulating hormone during radiotherapy to prevent primary hypothyroidism

Maura Massimino, Marta Podda, Lorenza Gandola, Emanuele Pignoli, Ettore Seregni, Carlo Morosi, Filippo Spreafico, Andrea Ferrari, Emilia Pecori, Monica Terenziani

Journal Article

Molecular characterization of two suppressor of cytokine signaling 1 genes (

Xue XU,Jiannan ZHANG,Juan LI,Yajun WANG

Journal Article

Effect of repeated gonadotropin stimulation on ovarian reserves and proliferation of ovarian surface epithelium in mice

Linlin LIANG, Bei XU, Guijin ZHU

Journal Article

Energy-aware fuzzy job-shop scheduling for engine remanufacturing at the multi-machine level

Jiali ZHAO, Shitong PENG, Tao LI, Shengping LV, Mengyun LI, Hongchao ZHANG

Journal Article

Full length cDNA cloning and expression of luteinizing hormone (LH) and which serum concentration was

Liu Xuezhou,Shi Bao,Wang Shanshan,Xu Yongjiang,Li Xiaoxiao

Journal Article