Resource Type

Journal Article 29

Conference Videos 1

Year

2023 2

2022 3

2021 3

2020 1

2019 2

2018 3

2017 1

2016 5

2013 1

2010 2

2009 2

2008 1

2007 1

2005 1

2004 1

open ︾

Keywords

immunity 6

innate immunity 3

plant immunity 3

active defense 2

active immunity 2

antiviral 2

inflammation 2

pathogenesis 2

Adenovirus serotype 5 1

Akkermansia muciniphila 1

Axin1 1

Bacteria 1

Cell death 1

Cyclic lipopeptide 1

DNA vaccine 1

Development 1

E3 ubiquitin ligase 1

Epstein-Barr virus 1

Gene expression pattern 1

open ︾

Search scope:

排序: Display mode:

Regulation of T cell immunity by cellular metabolism

Zhilin Hu, Qiang Zou, Bing Su

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 463-472 doi: 10.1007/s11684-018-0668-2

Abstract:

T cells are an important adaptive immune response arm that mediates cell-mediated immunity.

Keywords: T cell immunity     metabolic pathways     nutrient uptake     metabolic checkpoints    

Metabolism and immunity in breast cancer

Deyu Zhang, Xiaojie Xu, Qinong Ye

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 178-207 doi: 10.1007/s11684-020-0793-6

Abstract: For tumor-associated immunity, poor immunogenicity and heightened immunosuppression cause breast cancer

Keywords: breast cancer     metabolism     immunity     cancer stem cells    

Rhizosphere immunity: targeting the underground for sustainable plant health management

Zhong WEI, Ville-Petri FRIMAN, Thomas POMMIER, Stefan GEISEN, Alexandre JOUSSET, Qirong SHEN

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 3,   Pages 317-328 doi: 10.15302/J-FASE-2020346

Abstract: Here we present the concept of rhizosphere immunity, in which plant health is considered as an ecosysteminteractions can potentially extend the innate plant immune system to a point where the rhizosphere immunity

Keywords: rhizosphere     soil microbiome     plant immunity     microbial ecology     plant health     soilborne pathogens    

Toll-like receptors in innate immunity and infectious diseases

Min-Hao WU, Ping ZHANG, Xi HUANG,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 385-393 doi: 10.1007/s11684-010-0600-x

Abstract: 88 (MyD88)-dependent or-independent signaling respectively, thereby modulating innate and adaptive immunity

Keywords: Toll-like receptors     innate immunity     infectious disease     inflammation    

Immunogenicity and protective immunity against otitis media caused by pneumococcus in mice of Hib conjugate

Zeyu Chen,Rong Guo,Jianghong Xu,Chuangjun Qiu

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 490-498 doi: 10.1007/s11684-016-0470-y

Abstract:

This study evaluated the immunogenicity and protective immunity of a Hemophilus influenzaerate of pneumococcus and the inflammation of the middle ear showed the effectiveness of protective immunity

Keywords: conjugate vaccine     pneumococcal surface adhesin A     Hemophilus influenzae b     immunogenicity     otitis media    

Antitumor immunity of human SART3 gene vaccine against mouse tumor

HE Yu, YANG Shuhua, LIU Yong, LI Tao

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 51-57 doi: 10.1007/s11684-008-0010-5

Abstract: whether squamous cell carcinoma antigen recognized by human T cell 3 (SART3) gene can induce antitumor immunityOne group was challenged with tumor cells after immunity.

Keywords: antitumor therapy     occurrence     implantation     DNA vaccine     SART3 DNA    

HEMIPTERAN-TRANSMITTED PLANT VIRUSES: RESEARCH PROGRESS AND CONTROL STRATEGIES

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 1,   Pages 98-109 doi: 10.15302/J-FASE-2021389

Abstract: analyzes the key factors affecting insect transmission of plant viruses from the perspectives of insect immunity

Keywords: control strategies / feeding / immunity / insect vector / microorganism / plant virus    

Gut microbiota and its implications in small bowel transplantation

Chenyang Wang, Qiurong Li, Jieshou Li

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 239-248 doi: 10.1007/s11684-018-0617-0

Abstract:

The gut microbiota is mainly composed of a diverse population of commensal bacterial species and plays a pivotal role in the maintenance of intestinal homeostasis, immune modulation and metabolism. The influence of the gut microbiota on solid organ transplantation has recently been recognized. In fact, several studies indicated that acute and chronic allograft rejection in small bowel transplantation (SBT) is closely associated with the alterations in microbial patterns in the gut. In this review, we focused on the recent findings regarding alterations in the microbiota following SBT and the potential roles of these alterations in the development of acute and chronic allograft rejection. We also reviewed important advances with respect to the interplays between the microbiota and host immune systems in SBT. Furthermore, we explored the potential of the gut microbiota as a microbial marker and/or therapeutic target for the predication and intervention of allograft rejection and chronic dysfunction. Given that current research on the gut microbiota has become increasingly sophisticated and comprehensive, large cohort studies employing metagenomic analysis and multivariate linkage should be designed for the characterization of host–microbe interaction and causality between microbiota alterations and clinical outcomes in SBT. The findings are expected to provide valuable insights into the role of gut microbiota in the development of allograft rejection and other transplant-related complications and introduce novel therapeutic targets and treatment approaches in clinical practice.

Keywords: gut microbiota     small bowel transplantation     acute rejection     chronic rejection     mucosal immunity     biomarker    

RNA m6A modification and its function in diseases

Jiyu Tong, Richard A. Flavell, Hua-Bing Li

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 481-489 doi: 10.1007/s11684-018-0654-8

Abstract:

N6-methyladenosine (m6A) is the most common post-transcriptional RNA modification throughout the transcriptome, affecting fundamental aspects of RNA metabolism. m6A modification could be installed by m6A “writers” composed of core catalytic components (METTL3/METTL14/WTAP) and newly defined regulators and removed by m6A “erasers” (FTO and ALKBH5). The function of m6A is executed by m6A “readers” that bind to m6A directly (YTH domain-containing proteins, eIF3 and IGF2BPs) or indirectly (HNRNPA2B1). In the past few years, advances in m6A modulators (“writers,” “erasers,” and “readers”) have remarkably renewed our understanding of the function and regulation of m6A in different cells under normal or disease conditions. However, the mechanism and the regulatory network of m6A are still largely unknown. Moreover, investigations of the m6A physiological roles in human diseases are limited. In this review, we summarize the recent advances in m6A research and highlight the functional relevance and importance of m6A modification in in vitro cell lines, in physiological contexts, and in cancers.

Keywords: RNA modification     m6A     immunity     cancer     epigenetics    

TCM Views and Treatment on AIDS

Wang Wenkui

Strategic Study of CAE 2004, Volume 6, Issue 1,   Pages 44-47

Abstract: different kinds of virus, hence keeping physical and psychological well-being, strengthening the human immunity

Keywords: TCM views and theatment     HIV/AIDS     immunity     viscera function    

Expression of inducible nitric oxide synthase in trophoblasts and deciduas in early medical abortion

Geqing XIA, Chaoying WU

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 216-219 doi: 10.1007/s11684-009-0028-3

Abstract: The purpose of this study was to investigate the expression of inducible nitric oxide synthase in trophoblasts and deciduas in early medical abortion, and study the relationship of medical abortion through mifepristone and inducible nitric oxide synthase (iNOS) in early pregnancy. Expression of iNOS in trophoblasts and deciduas was detected by both hybridization and immunohistochemical assay in 40 patients (experimental group); the positive expression of iNOS was represented by number density (N/S) and positive unit (Pu) using computer color magic image analysis system (CMIAS). All results were compared with that obtained from vacuum aspiration. In the experimental group, N/S and Pu in trophoblasts were 0.120 ± 0.010 and 15.3 ± 2.6, respectively, while in the control group, they were 0.021 ± 0.003 and 3.1 ± 0.5, respectively, and there were significant differences between the two groups. By immunohistochemical assay, N/S and Pu were 0.090 ± 0.010, 10.24 ± 1.55 0.016 ± 0.002, 1.26 ± 0.33 in the trophoblasts of the two groups; there were also significant differences between the two groups. There were lower iNOS expressions in deciduas by in situ hybridization and immunohistochemical assay, and the difference between the two groups was not significant.It was concluded that mifepristone induced medical abortion through the expression of iNOS in trophoblasts but not in deciduas.

Keywords: mifepristone     inducible nitric oxide synthase     early pregnancy     placental immunity    

Critical roles of chemokines and cytokines in antiviral innate immune responses during rabies virus infection

Ying HUANG, Clement Wesley GNANADURAI, Zhenfang FU

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3,   Pages 260-267 doi: 10.15302/J-FASE-2016116

Abstract: The innate immune response is the first line of defense against viral invasion and pro-inflammatory chemokines and cytokines have a critical function in the innate immune responses against virus infections. The ability of a rabies virus (RABV) to induce the expression of chemokines and cytokines can lead to viral clearance from the central nervous system (CNS), whereas the ability to evade such expression and activation contributes to virulence and pathogenicity. In this review, the crucial contribution of chemokines/cytokines to clearing RABV from the CNS is discussed, including recruiting leukocytes into the CNS, enhancement of blood brain barrier permeability and activation of various immune cells that are essential for viral clearance. In addition, recombinant RABV expressing cytokines and chemokines can induce elevated innate and adaptive immune responses which result in clearing an established wild-type RABV infection in the CNS.

Keywords: antiviral     blood brain barrier     chemokines and cytokines     innate immunity     rabies virus    

Systems understanding of plant–pathogen interactions through genome-wide protein–protein interaction networks

Hong LI,Ziding ZHANG

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 2,   Pages 102-112 doi: 10.15302/J-FASE-2016100

Abstract: To effectively defend against such infections, two major modes of innate immunity have evolved in plants; pathogen-associated molecular pattern-triggered immunity and effector-triggered immunity.

Keywords: plant–pathogen interactions     systems biology     omics     plant immunity     protein–protein interaction     network    

Role of Intrahepatic Regional Immunity in Post-Transplant Cancer Recurrence Review

Jiang Liu,Chung Mau Lo,Kwan Man

Engineering 2022, Volume 10, Issue 3,   Pages 57-64 doi: 10.1016/j.eng.2021.11.012

Abstract: However, the role of regional immunity in post-transplant cancer recurrence is not comprehensively understoodA comprehensive understanding of regional immunity will provide novel precise diagnostic, therapeutic

Keywords: Liver transplantation     Liver cancer     Recurrence     Immunology    

Lung-Targeted Transgene Expression of Nanocomplexed Ad5 Enhances Immune Response in the Presence of Preexisting Immunity Article

Yilong Yang, Shipo Wu, Yudong Wang, Fangze Shao, Peng Lv, Ruihua Li, Xiaofan Zhao, Jun Zhang, Xiaopeng Zhang, Jianmin Li, Lihua Hou, Junjie Xu, Wei Chen

Engineering 2023, Volume 27, Issue 8,   Pages 127-139 doi: 10.1016/j.eng.2022.12.007

Abstract: However, the high prevalence of preexisting anti-vector immunity compromises the immunogenicity of Ad5Thus, there is a substantial unmet need to minimize preexisting immunity while improving the insert-inducedimmunity of Ad5 vectors.Importantly, in the presence of preexisting anti-Ad5 immunity, complexed Ad5-based Ebola and COVID-19vaccines significantly enhance antigen-specific humoral response and mucosal immunity.

Keywords: Adenovirus serotype 5     Vaccine     Preexisting immunity     Nanoparticles     Transgene expression    

Title Author Date Type Operation

Regulation of T cell immunity by cellular metabolism

Zhilin Hu, Qiang Zou, Bing Su

Journal Article

Metabolism and immunity in breast cancer

Deyu Zhang, Xiaojie Xu, Qinong Ye

Journal Article

Rhizosphere immunity: targeting the underground for sustainable plant health management

Zhong WEI, Ville-Petri FRIMAN, Thomas POMMIER, Stefan GEISEN, Alexandre JOUSSET, Qirong SHEN

Journal Article

Toll-like receptors in innate immunity and infectious diseases

Min-Hao WU, Ping ZHANG, Xi HUANG,

Journal Article

Immunogenicity and protective immunity against otitis media caused by pneumococcus in mice of Hib conjugate

Zeyu Chen,Rong Guo,Jianghong Xu,Chuangjun Qiu

Journal Article

Antitumor immunity of human SART3 gene vaccine against mouse tumor

HE Yu, YANG Shuhua, LIU Yong, LI Tao

Journal Article

HEMIPTERAN-TRANSMITTED PLANT VIRUSES: RESEARCH PROGRESS AND CONTROL STRATEGIES

Journal Article

Gut microbiota and its implications in small bowel transplantation

Chenyang Wang, Qiurong Li, Jieshou Li

Journal Article

RNA m6A modification and its function in diseases

Jiyu Tong, Richard A. Flavell, Hua-Bing Li

Journal Article

TCM Views and Treatment on AIDS

Wang Wenkui

Journal Article

Expression of inducible nitric oxide synthase in trophoblasts and deciduas in early medical abortion

Geqing XIA, Chaoying WU

Journal Article

Critical roles of chemokines and cytokines in antiviral innate immune responses during rabies virus infection

Ying HUANG, Clement Wesley GNANADURAI, Zhenfang FU

Journal Article

Systems understanding of plant–pathogen interactions through genome-wide protein–protein interaction networks

Hong LI,Ziding ZHANG

Journal Article

Role of Intrahepatic Regional Immunity in Post-Transplant Cancer Recurrence

Jiang Liu,Chung Mau Lo,Kwan Man

Journal Article

Lung-Targeted Transgene Expression of Nanocomplexed Ad5 Enhances Immune Response in the Presence of Preexisting Immunity

Yilong Yang, Shipo Wu, Yudong Wang, Fangze Shao, Peng Lv, Ruihua Li, Xiaofan Zhao, Jun Zhang, Xiaopeng Zhang, Jianmin Li, Lihua Hou, Junjie Xu, Wei Chen

Journal Article