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Journal Article 4

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2022 2

2016 2

Keywords

COVID-19 2

SARS-CoV-2 2

immunogenicity 2

vaccine 2

RR1 and RR2 1

Hemophilus influenzae b 1

booster immunization 1

conjugate vaccine 1

effectiveness 1

efficacy 1

immunization 1

otitis media 1

pneumococcal surface adhesin A 1

pseudorabies virus 1

ribonucleotide reductase 1

safety 1

vaccine candidate 1

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Early assessment of the safety and immunogenicity of a third dose (booster) of COVID-19 immunization

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 93-101 doi: 10.1007/s11684-021-0914-x

Abstract: Safety and immunogenicity in terms of neutralizing antibody titers and cytokine/chemokine responses were

Keywords： COVID-19     SARS-CoV-2     vaccine     immunization     booster immunization    

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Immunogenicity and protective immunity against otitis media caused by pneumococcus in mice of Hib conjugate

Zeyu Chen,Rong Guo,Jianghong Xu,Chuangjun Qiu

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 490-498 doi: 10.1007/s11684-016-0470-y

Abstract:

This study evaluated the immunogenicity and protective immunity of a Hemophilus influenzae

Keywords： conjugate vaccine     pneumococcal surface adhesin A     Hemophilus influenzae b     immunogenicity     otitis media    

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A review of the safety and efficacy of current COVID-19 vaccines

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 39-55 doi: 10.1007/s11684-021-0893-y

Abstract: This study reviewed the efficacy/effectiveness, immunogenicity, and safety profile of the 12 most progressed

Keywords： COVID-19     SARS-CoV-2     vaccine     safety     efficacy     effectiveness     immunogenicity    

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RR1 and RR2 gene deletion affects the immunogenicity of a live attenuated pseudorabies

Shijun YAN,He YAN,Chaolin ZHANG,Tongyan WANG,Qingyuan YANG,Zhe SUN,Yan XIAO,Feifei TAN,Xiangdong LI,Kegong TIAN

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 1,   Pages 81-86 doi: 10.15302/J-FASE-2016088

Abstract: As virulence-determining genes, and encode the small subunit and large subunit of viral ribonucleotide reductase (RR) in pseudorabies virus which have been extensively studied in mice. However, their role in pigs has not been adequately investigated. In this study, we deleted and genes based on a / / triple gene-deleted pseudorabies virus and tested its efficacy in pigs as a vaccine candidate. The rescued virus showed similar growth properties and plaque size as its parent strain. In an animal study, the virus could elicit humoral immune responses shown by generation of gB-specific antibodies and virus neutralizing antibodies. However, vaccination could not provide protection against virulent pseudorabies virus challenge since vaccinated pigs showed clinical pseudorabies-specific syndromes. The deficiency in protection may due to the generation of late and low levels of gB antibodies and virus neutralizing antibodies.

Keywords： pseudorabies virus     RR1 and RR2     ribonucleotide reductase     vaccine candidate    

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Title Author Date Type Operation

Early assessment of the safety and immunogenicity of a third dose (booster) of COVID-19 immunization

Journal Article

Immunogenicity and protective immunity against otitis media caused by pneumococcus in mice of Hib conjugate

Zeyu Chen,Rong Guo,Jianghong Xu,Chuangjun Qiu

Journal Article

A review of the safety and efficacy of current COVID-19 vaccines

Journal Article

RR1 and RR2 gene deletion affects the immunogenicity of a live attenuated pseudorabies

Shijun YAN,He YAN,Chaolin ZHANG,Tongyan WANG,Qingyuan YANG,Zhe SUN,Yan XIAO,Feifei TAN,Xiangdong LI,Kegong TIAN

Journal Article