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Prospects of immunotherapy for cancer
Zhinan Chen
Frontiers of Medicine 2019, Volume 13, Issue 1, Pages 1-2 doi: 10.1007/s11684-019-0691-y
Immunometabolism: a new dimension in immunotherapy resistance
Frontiers of Medicine 2023, Volume 17, Issue 4, Pages 585-616 doi: 10.1007/s11684-023-1012-z
Keywords: immune cell immunometabolism metabolic reprogramming immunotherapy resistance tumor microenvironment
Dendritic cell vaccines in cancer immunotherapy: from biology to translational medicine
Hongmei Xu, Xuetao Cao
Frontiers of Medicine 2011, Volume 5, Issue 4, Pages 323-332 doi: 10.1007/s11684-011-0172-4
Challenges of NK cell-based immunotherapy in the new era
Fang Fang, Weihua Xiao, Zhigang Tian
Frontiers of Medicine 2018, Volume 12, Issue 4, Pages 440-450 doi: tzg@ustc.edu.cn
Natural killer cells (NKs) have a great potential for cancer immunotherapy because they can rapidly
Keywords: natural killer cells immunotherapy adoptive transfer genetic modification immune checkpoint inhibitor
CAR T-cell immunotherapy: a powerful weapon for fighting hematological B-cell malignancies
Frontiers of Medicine 2021, Volume 15, Issue 6, Pages 783-804 doi: 10.1007/s11684-021-0904-z
Keywords: CAR T cells hematological malignancies review
Developing effective tumor vaccines: basis, challenges and perspectives
XU Qingwen, CHEN Weifeng
Frontiers of Medicine 2007, Volume 1, Issue 1, Pages 11-19 doi: 10.1007/s11684-007-0003-9
Keywords: development conventional identification elucidation Successful immunotherapy
Regulatory T Cells and Their Clinical Applications in Antitumor Immunotherapy Review
Feng Xie, Rui Liang, Dan Li, Bin Li
Engineering 2019, Volume 5, Issue 1, Pages 132-139 doi: 10.1016/j.eng.2018.12.002
Keywords: Regulatory T cells Cancer Immunotherapy
Chuangnian Zhang, Ying Dong, Jing Gao, Xiaoli Wang, Yanjun Jiang
Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 5, Pages 1296-1311 doi: 10.1007/s11705-020-2034-6
Keywords: silica nanoflower antigen delivery cancer immunotherapy nanovaccine
Frontiers of Medicine 2022, Volume 16, Issue 1, Pages 139-149 doi: 10.1007/s11684-021-0835-8
Keywords: B-cell acute lymphoblastic leukemia bispecific antibody trispecific antibody CD19 CD20
Activation of phagocytosis by immune checkpoint blockade
Chia-Wei Li, Yun-Ju Lai, Jennifer L. Hsu, Mien-Chie Hung
Frontiers of Medicine 2018, Volume 12, Issue 4, Pages 473-480 doi: 10.1007/s11684-018-0657-5
Inhibition of macrophage-mediated phagocytosis has emerged as an essential mechanism for tumor immune evasion. One mechanism inhibiting the innate response is the presence of the macrophage inhibitory molecule, signal regulatory protein-α (SIRPα), on tumor-associated macrophages (TAMs) and its cognate ligand cluster of differentiation 47 (CD47) on tumor cells in the tumor microenvironment. On the basis of a recently discovered programmed death protein 1 (PD-1) in TAMs, we discuss the potential inhibitory receptors that possess new functions beyond T cell exhaustion in this review. As more and more immune receptors are found to be expressed on TAMs, the corresponding therapies may also stimulate macrophages for phagocytosis and thereby provide extra anti-tumor benefits in cancer therapy. Therefore, identification of biomarkers and combinatorial therapeutic strategies, have the potential to improve the efficacy and safety profiles of current immunotherapies.
Keywords: CD47 PD-1 PD-L1 immunotherapy TAM phagocytosis macrophage
Natural Killer Cell-Based Immunotherapy for Cancer: Advances and Prospects Review
Yuan Hu, Zhigang Tian, Cai Zhang
Engineering 2019, Volume 5, Issue 1, Pages 106-114 doi: 10.1016/j.eng.2018.11.015
Keywords: Natural killer cell Immunotherapy Cancer Clinical trial Chimeric antigen receptor
Translational medicine in hepatocellular carcinoma
Qiang Gao, Yinghong Shi, Xiaoying Wang, Jian Zhou, Shuangjian Qiu, Jia Fan
Frontiers of Medicine 2012, Volume 6, Issue 2, Pages 122-133 doi: 10.1007/s11684-012-0193-7
Keywords: hepatocellular carcinoma molecular classification molecular targeted therapies tumor microenvironment immunotherapy
Prospect of Medical Disruptive Technologies
Li Yongjie, Yang Juntao, Du Jian
Strategic Study of CAE 2018, Volume 20, Issue 6, Pages 64-68 doi: 10.15302/J-SSCAE-2018.06.010
Keywords: medical technology disruptive technology tumor immunotherapy gene editing
Emerging immunological strategies: recent advances and future directions
Frontiers of Medicine 2021, Volume 15, Issue 6, Pages 805-828 doi: 10.1007/s11684-021-0886-x
Keywords: cancer immunotherapy bispecific antibodies small molecules chimeric antigen receptor T therapy cancer
Analysis of interactions of immune checkpoint inhibitors with antibiotics in cancer therapy
Frontiers of Medicine 2022, Volume 16, Issue 3, Pages 307-321 doi: 10.1007/s11684-022-0927-0
Keywords: tumor immunotherapy immune checkpoint inhibitor antibiotics gut microbiota drug–drug interaction
Title Author Date Type Operation
Dendritic cell vaccines in cancer immunotherapy: from biology to translational medicine
Hongmei Xu, Xuetao Cao
Journal Article
Challenges of NK cell-based immunotherapy in the new era
Fang Fang, Weihua Xiao, Zhigang Tian
Journal Article
CAR T-cell immunotherapy: a powerful weapon for fighting hematological B-cell malignancies
Journal Article
Developing effective tumor vaccines: basis, challenges and perspectives
XU Qingwen, CHEN Weifeng
Journal Article
Regulatory T Cells and Their Clinical Applications in Antitumor Immunotherapy
Feng Xie, Rui Liang, Dan Li, Bin Li
Journal Article
and novel CD3/CD19/CD20 trispecific antibodies against B-cell acute lymphoblastic leukemia: targeted immunotherapy
Journal Article
Activation of phagocytosis by immune checkpoint blockade
Chia-Wei Li, Yun-Ju Lai, Jennifer L. Hsu, Mien-Chie Hung
Journal Article
Natural Killer Cell-Based Immunotherapy for Cancer: Advances and Prospects
Yuan Hu, Zhigang Tian, Cai Zhang
Journal Article
Translational medicine in hepatocellular carcinoma
Qiang Gao, Yinghong Shi, Xiaoying Wang, Jian Zhou, Shuangjian Qiu, Jia Fan
Journal Article